Analysis of the Preventive Effect of Lonicera caerulea Pomace and Its Isolated Components on Colitis in Mice Based on Gut Microbiota and Serum Metabolomics DOI Creative Commons
Zijin Zhou, Xinwen Huang, Baixi Zhang

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1478 - 1478

Опубликована: Ноя. 30, 2024

Inflammatory bowel disease (IBD), including relapsing-remitting ulcerative colitis and Crohn’s disease, is a non-specific chronic intestinal inflammatory disease. Lonicera caerulea, which rich in polyphenolic compounds, has been shown to exert antioxidative anti-inflammatory effects. The research evaluates the dietary impacts of caerulea pomace, its polyphenol-rich extract, fiber-rich residue on symptoms. Colitis was induced with 2.5% DSS (dextran sulfate sodium) aqueous solution after continuous feeding customized feed for 2.5 weeks. results indicate that intake extract an effect preventing mice, but less than by pomace itself, fiber alone does not prevent condition when ingested. have positive regulatory gut microbiota mice colitis, significantly restores 15 metabolites improving five metabolic pathways, steroid biosynthesis, regulation pathways being correlated microbiota.

Язык: Английский

Consistency in bacterial extracellular vesicle production: key to their application in human health DOI Open Access
Ke Dai, Bo Liao, Xiaotian Huang

и другие.

Extracellular Vesicles and Circulating Nucleic Acids, Год журнала: 2025, Номер 6(1), С. 1 - 20

Опубликована: Янв. 17, 2025

Bacterial extracellular vesicles (BEVs) are naturally occurring functional structures that play critical roles in bacterial life processes. These vesicles, commonly known as outer membrane (OMVs), were first found to be released by Gram-negative bacteria; however, it has since been confirmed Gram-positive bacteria also secrete BEVs. As research advances, BEVs increasingly utilized diverse applications, including vaccine development and drug delivery. Nevertheless, the effective employment of these contexts requires acquisition with consistent properties functions through appropriate culture, isolation, purification methods. This review examines advantages disadvantages various techniques alongside heterogeneity they may introduce. We utilize a framework critically analyze barriers their application factors influencing characteristics. Additionally, we constructively propose solutions enhance consistency BEVs, thereby facilitating further application.

Язык: Английский

Процитировано

0
Analysis of the Preventive Effect of Lonicera caerulea Pomace and Its Isolated Components on Colitis in Mice Based on Gut Microbiota and Serum Metabolomics DOI Creative Commons
Zijin Zhou, Xinwen Huang, Baixi Zhang

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1478 - 1478

Опубликована: Ноя. 30, 2024

Inflammatory bowel disease (IBD), including relapsing-remitting ulcerative colitis and Crohn’s disease, is a non-specific chronic intestinal inflammatory disease. Lonicera caerulea, which rich in polyphenolic compounds, has been shown to exert antioxidative anti-inflammatory effects. The research evaluates the dietary impacts of caerulea pomace, its polyphenol-rich extract, fiber-rich residue on symptoms. Colitis was induced with 2.5% DSS (dextran sulfate sodium) aqueous solution after continuous feeding customized feed for 2.5 weeks. results indicate that intake extract an effect preventing mice, but less than by pomace itself, fiber alone does not prevent condition when ingested. have positive regulatory gut microbiota mice colitis, significantly restores 15 metabolites improving five metabolic pathways, steroid biosynthesis, regulation pathways being correlated microbiota.

Язык: Английский

Процитировано

1