Carrier-free nanoparticles—new strategy of improving druggability of natural products DOI Creative Commons

Youyun Yao,

Zhenghu Xu, Hang Ding

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 14, 2025

There are abundant natural products resources and extensive clinical use experience in China. However, the active components of generally have problems such as poor water solubility low bioavailability, which limit their druggability. Carrier-free nanoparticles, nanocrystals, self-assembled extracellular vesicles derived from both animal plant sources, great application potential improving safety efficacy drugs due to simple flexible preparation methods, high drug loading capacity delivery efficiency, well long half-life blood circulation. It has been widely used biomedical fields anti-tumor, anti-bacterial, anti-inflammatory anti-oxidation. Therefore, based on that clinic, this review focuses advantages carrier-free nanoparticles delivering compounds, order improve process vivo draggability.

Язык: Английский

Carrier-free nanoparticles—new strategy of improving druggability of natural products DOI Creative Commons

Youyun Yao,

Zhenghu Xu, Hang Ding

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 14, 2025

There are abundant natural products resources and extensive clinical use experience in China. However, the active components of generally have problems such as poor water solubility low bioavailability, which limit their druggability. Carrier-free nanoparticles, nanocrystals, self-assembled extracellular vesicles derived from both animal plant sources, great application potential improving safety efficacy drugs due to simple flexible preparation methods, high drug loading capacity delivery efficiency, well long half-life blood circulation. It has been widely used biomedical fields anti-tumor, anti-bacterial, anti-inflammatory anti-oxidation. Therefore, based on that clinic, this review focuses advantages carrier-free nanoparticles delivering compounds, order improve process vivo draggability.

Язык: Английский

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