Association between the dietary index for gut microbiota and cardiometabolic multimorbidity: systemic immune-inflammation index and systemic inflammatory response index DOI Creative Commons

Sihan Hu,

Jiheon Song, Hui Jiang

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Июнь 5, 2025

Objective This study targets to investigate the connection between possibility of Cardiometabolic Multimorbidity (CMM) and Dietary Index for Gut Microbiota (DI-GM), paying special attention mediating roles systemic inflammatory markers, specifically Systemic Immune-Inflammation (SII) Inflammatory Response (SIRI). Methods A cross-sectional was conducted involving 17,388 eligible participants from National Health Nutrition Examination Survey (NHANES) spanning 2007 2020. Weighted logistic regression model employed assess correlation DI-GM, SII, SIRI, CMM. Additionally, restricted cubic spline (RCS) utilized any potential nonlinear relationships these variables risk The degree which SII SIRI mediated link CMM DI-GM assessed using mediation analysis. sensitivity subgroup analyses were confirm results. Results lower markedly correlated with higher scores (OR = 0.94, 95% CI: 0.91–0.98, p 0.001). An elevated linked levels Ln-SII Ln-SIRI 1.45, 1.28–1.65, < 0.001; OR 1.87, 1.69–2.07, Higher education associated a stronger protective effect on CMM, according analysis ( P interaction 0.05). accounted 8.3 18.1% total effect, respectively, partially Sensitivity proved stability findings. Conclusion According study’s findings, could mitigate danger Reduced inflammation acted as partial factor in this connection. These findings highlight mechanisms gut microbiota nutritional perspective. offers insightful information clinical therapy prevention.

Язык: Английский

Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study DOI Creative Commons
Qingxia Yang,

Xiaoyun Wu,

Jianguo Duan

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 16, 2025

Frailty is a prevalent geriatric syndrome marked by diminished physiological reserves and heightened vulnerability to stressors, leading adverse health outcomes imposing significant economic burdens on healthcare systems. This study investigates the relationship between Dietary Index for Gut Microbiota (DI-GM) risk of frailty in middle-aged older adults, using data from National Health Nutrition Examination Survey (NHANES) collected 2007 2018. Weighted logistic regression, subgroup analysis, restricted cubic splines (RCS) were performed evaluate DI-GM risk. Additionally, mediation analysis was conducted investigate influence relevant inflammatory parameters complete blood count, including leukocyte neutrophil lymphocyte ratio (NLR), systemic response index (SIRI), elucidate how may onset progression frailty. In this cross-sectional 8,695 participants with mean age 65.56 years, 3,173 individuals classified as frail. After adjusting all covariates, inverse observed Quartile revealed that highest quartile had significantly lower odds compared those lowest (OR: 0.80, 95% CI: 0.65-0.99, p = 0.04). Trend analyses across models demonstrated consistent higher quartiles (p < 0.0001 crude model; 0.001 Model 1; 0.04 2). Subgroup confirmed stability impact various subgroups. RCS showed decreased linearly increasing levels. Mediation indicated effects NLR, SIRI, proportions 5.7, 7.9, 4.4, 5.5%, respectively (all 0.001). The levels are inversely associated frailty, part association mediated parameters.

Язык: Английский

Процитировано

0

Association between dietary index for gut microbiota and female infertility: a cross-sectional NHANES 2013–2020 DOI Creative Commons
Yu Fu,

Mengling Peng,

He Cai

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 23, 2025

The relationship between the gut microbiota and infertility has garnered increasing attention. However, associations dietary index for (DI-GM), an indicator of microbial diversity, remain insufficiently explored. We analyzed data from 3,058 participants in NHANES 2013-2020 cycles, employing weighted generalized linear models smooth curve analyses to examine their associations. Mediation analysis was conducted assess role body mass (BMI). After adjusting confounding factors, a higher DI-GM score significantly associated with lower prevalence (OR = 0.89, 95% CI 0.81-0.98, p 0.029). Compared individuals 0-3, those ≥6 presented 0.64, 0.43-0.96, 0.039). BMI mediated 5.98% association infertility. A is Future studies should employ longitudinal designs validate these findings.

Язык: Английский

Процитировано

0

Association between the dietary index for gut microbiota and female infertility: a cross-sectional study of NHANES 2013–2018 DOI Creative Commons

Xiaoyan Zhang,

Liangzhi Wu, Haiyan Li

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 28, 2025

Infertility poses a substantial societal and economic burden; however, current preventive strategies are limited. Recently, the relationship between gut microbiota infertility has garnered increasing attention. The dietary index for (DI-GM) is new that reflects diversity of microbiota. However, its association with female remains unclear. This cross-sectional study included 3,053 women aged 18-45 years from National Health Nutrition Examination Survey (NHANES) database 2013 2018. was defined based on responses to questionnaire reproductive health. DI-GM score calculated by averaging intake two 24-h recall interviews. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses were used investigate infertility. Based self-reported data, 370 participants (12.12%) classified as infertile. A higher proportion lower scores experienced Multivariable regression analysis indicated negative risk infertility, regardless whether independent variable analyzed continuous or in quartiles fully adjusted model (Model 3, variable: OR = 0.89, 95% confidence interval (CI): 0.80-0.98, p 0.025; Q4 vs. Q1: 0.63, CI 0.42-0.94, 0.032, trend 0.013). RCS curves demonstrated non-linear risk. Subsequent corroborated robustness these findings. These findings suggest females, associated

Язык: Английский

Процитировано

0

Association between the dietary index for gut microbiota and atherosclerotic cardiovascular disease risk among US elderly adults: a cross‑sectional study DOI Creative Commons

Meiqi Miao,

Shigang Qiao, Wen Pan

и другие.

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Май 11, 2025

Gut microbes are important for the development of atherosclerotic cardiovascular disease (ASCVD), and dietary index gut microbiota (DI-GM), a new measure flora-friendly diets, has not been systematically investigated in relation to ASCVD. This study aimed evaluate correlation between DI-GM risk ASCVD American older adults, also analyze mediating role body mass (BMI). Researchers selected 2234 elderly participants ≥ 65 years age from National Health Nutrition Examination Survey (NHANES) 2015 2018 cross-sectional cohort study. Stratified analyses were taken based on quartile. To achieve our research objectives, we employed logistic regression analysis, smooth curve fitting, interaction effects mediation analysis. After adjusting confounders, individuals with higher had significantly lower (highest quartile vs. lowest OR = 0.73, 95% CI: 0.52-1.01, P < 0.001). was linearly negatively associated (P 0.13) association stable diabetes subgroup (interaction > 0.05), but age, gender BMI may modify 0.05). mediated 11.51% (95% 2.54%-54.1%, 0.016). is likely be promising indicator assessment ASCVD, exhibiting partial effect this association. Future studies should prioritize comprehensive investigation underlying mechanisms by which contributes atherogenesis, aim enhancing efficacy early prevention strategies

Язык: Английский

Процитировано

0

Associations between dietary index for gut microbiota and stroke, and the mediating role of inflammation: a prospective cohort study DOI Creative Commons
Min Liu,

Meng Han,

Yan Fu

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The dietary index for gut microbiota was associated with a reduced risk of stroke, inflammation partially mediating this association.

Язык: Английский

Процитировано

0

Dietary Index for Gut Microbiota is negatively associated with Hypertension DOI
Yu Fu,

Mengling Peng,

He Cai

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Abstract Background The relationship between the gut microbiota and hypertension has gained increasing attention. However, associations Dietary Index for Gut Microbiota (DI-GM), an indicator of diversity, remain insufficiently explored. We hypothesized that a higher DI-GM score would be associated with lower prevalence hypertension. Methods analyzed data from 20,283 participants in National Health Nutrition Examination Survey (NHANES) 2007–2016 cycle via weighted generalized linear models smooth curve fitting to examine association Mediation analysis was conducted evaluate role eGFR waist circumference. Results After adjusting confounding factors, significantly (OR = 0.94, 95% CI 0.92–0.97). Compared individuals 0–3, those ≥ 6 had 0.77, 0.69–0.86). mediation indicated circumference accounted 5.91% 3.91%, respectively, Conclusion A is hypertension, which partially mediated by

Язык: Английский

Процитировано

0

Association of the Dietary Index for Gut Microbiota With Severity, Renal Function, and Sarcopenia in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study DOI
Xiaofeng Xu,

Huiyi Su,

Junhong Chen

и другие.

Journal of the American Nutrition Association, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Май 18, 2025

The aim of this research was to clarify the relationship between Dietary Index for Gut Microbiota (DI-GM) and severity chronic kidney disease (CKD), renal function, prevalence sarcopenia in patients with CKD, as well role Systemic Immune-Inflammation (SII) therein. Using data from National Health Nutrition Examination Survey (NHANES) 2007-2018, study included 2169 participants CKD. DI-GM calculated on a scale 0 13, higher scores indicating healthier gut microbiome. CKD categorized by estimated glomerular filtration rate (eGFR), defined using appendicular lean mass adjusted body index. Statistical analyses weighted regression models, restricted cubic spline, subgroup analysis, mediation analysis. Higher were associated lower (odds ratio [OR], 0.85; 95% confidence interval [CI], 0.78-0.94; p = .001), improved function (eGFR, β 1.078, .020; serum creatinine, -1.548, .026; blood urea nitrogen, -0.091, .026), reduced (OR, 0.70; CI, 0.57-0.87; .002). SII score partially mediated association accounting 12.11% effect (p < .001). No significant associations found all-cause or cardiovascular mortality among population Findings suggest that dietary interventions targeting microbiota may have benefits managing severity, improving reducing risk.

Язык: Английский

Процитировано

0

Commentary: Association between metallic implants and stroke in US adults from NHANES 2015–2023 a cross-sectional study DOI Creative Commons
Xian Wang,

Peixing Huang,

Gelun Huang

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Май 21, 2025

Язык: Английский

Процитировано

0

The relationship between dietary index for gut microbiota and hyperuricemia: a cross-sectional study using NHANES data DOI Creative Commons
Xin Cai, Shaoqin Zhang,

Tianzuo Lan

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Май 26, 2025

Background Hyperuricemia (HUA) is a common metabolic disorder, yet the impact of diet and gut microbiota on uric acid metabolism remains insufficiently understood. This study aims to investigate relationship between dietary index for (DI-GM) HUA using data from National Health Nutrition Examination Survey (NHANES). Methods employed NHANES gathered 2007 2020, encompassing 25,899 adults aged 18 years older. The DI-GM, which spans 0 14, was calculated based recall information. diagnosis established through laboratory findings. To examine DI-GM HUA, multivariable logistic regression utilized, accounting pertinent confounding variables. Results Upon adjusting possible variables, an elevated score demonstrated notable correlation with reduced likelihood [odds ratio (OR) = 0.968, 95% confidence interval (CI) 0.949–0.987, p 0.005]. Subjects exhibiting ≥6 markedly risk in contrast those scoring 3 (OR 0.897, CI 0.821–0.980, 0.016). Conclusion A higher inversely related HUA.

Язык: Английский

Процитировано

0

Association between dietary index for gut microbiota and sleep duration in US adults: a cross-sectional study DOI Creative Commons
Jingjing Liu, Shaoqiang Huang

Current Research in Microbial Sciences, Год журнала: 2025, Номер unknown, С. 100412 - 100412

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0