Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Июнь 5, 2025
Objective
This
study
targets
to
investigate
the
connection
between
possibility
of
Cardiometabolic
Multimorbidity
(CMM)
and
Dietary
Index
for
Gut
Microbiota
(DI-GM),
paying
special
attention
mediating
roles
systemic
inflammatory
markers,
specifically
Systemic
Immune-Inflammation
(SII)
Inflammatory
Response
(SIRI).
Methods
A
cross-sectional
was
conducted
involving
17,388
eligible
participants
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2007
2020.
Weighted
logistic
regression
model
employed
assess
correlation
DI-GM,
SII,
SIRI,
CMM.
Additionally,
restricted
cubic
spline
(RCS)
utilized
any
potential
nonlinear
relationships
these
variables
risk
The
degree
which
SII
SIRI
mediated
link
CMM
DI-GM
assessed
using
mediation
analysis.
sensitivity
subgroup
analyses
were
confirm
results.
Results
lower
markedly
correlated
with
higher
scores
(OR
=
0.94,
95%
CI:
0.91–0.98,
p
0.001).
An
elevated
linked
levels
Ln-SII
Ln-SIRI
1.45,
1.28–1.65,
<
0.001;
OR
1.87,
1.69–2.07,
Higher
education
associated
a
stronger
protective
effect
on
CMM,
according
analysis
(
P
interaction
0.05).
accounted
8.3
18.1%
total
effect,
respectively,
partially
Sensitivity
proved
stability
findings.
Conclusion
According
study’s
findings,
could
mitigate
danger
Reduced
inflammation
acted
as
partial
factor
in
this
connection.
These
findings
highlight
mechanisms
gut
microbiota
nutritional
perspective.
offers
insightful
information
clinical
therapy
prevention.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 16, 2025
Frailty
is
a
prevalent
geriatric
syndrome
marked
by
diminished
physiological
reserves
and
heightened
vulnerability
to
stressors,
leading
adverse
health
outcomes
imposing
significant
economic
burdens
on
healthcare
systems.
This
study
investigates
the
relationship
between
Dietary
Index
for
Gut
Microbiota
(DI-GM)
risk
of
frailty
in
middle-aged
older
adults,
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
collected
2007
2018.
Weighted
logistic
regression,
subgroup
analysis,
restricted
cubic
splines
(RCS)
were
performed
evaluate
DI-GM
risk.
Additionally,
mediation
analysis
was
conducted
investigate
influence
relevant
inflammatory
parameters
complete
blood
count,
including
leukocyte
neutrophil
lymphocyte
ratio
(NLR),
systemic
response
index
(SIRI),
elucidate
how
may
onset
progression
frailty.
In
this
cross-sectional
8,695
participants
with
mean
age
65.56
years,
3,173
individuals
classified
as
frail.
After
adjusting
all
covariates,
inverse
observed
Quartile
revealed
that
highest
quartile
had
significantly
lower
odds
compared
those
lowest
(OR:
0.80,
95%
CI:
0.65-0.99,
p
=
0.04).
Trend
analyses
across
models
demonstrated
consistent
higher
quartiles
(p
<
0.0001
crude
model;
0.001
Model
1;
0.04
2).
Subgroup
confirmed
stability
impact
various
subgroups.
RCS
showed
decreased
linearly
increasing
levels.
Mediation
indicated
effects
NLR,
SIRI,
proportions
5.7,
7.9,
4.4,
5.5%,
respectively
(all
0.001).
The
levels
are
inversely
associated
frailty,
part
association
mediated
parameters.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 23, 2025
The
relationship
between
the
gut
microbiota
and
infertility
has
garnered
increasing
attention.
However,
associations
dietary
index
for
(DI-GM),
an
indicator
of
microbial
diversity,
remain
insufficiently
explored.
We
analyzed
data
from
3,058
participants
in
NHANES
2013-2020
cycles,
employing
weighted
generalized
linear
models
smooth
curve
analyses
to
examine
their
associations.
Mediation
analysis
was
conducted
assess
role
body
mass
(BMI).
After
adjusting
confounding
factors,
a
higher
DI-GM
score
significantly
associated
with
lower
prevalence
(OR
=
0.89,
95%
CI
0.81-0.98,
p
0.029).
Compared
individuals
0-3,
those
≥6
presented
0.64,
0.43-0.96,
0.039).
BMI
mediated
5.98%
association
infertility.
A
is
Future
studies
should
employ
longitudinal
designs
validate
these
findings.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 28, 2025
Infertility
poses
a
substantial
societal
and
economic
burden;
however,
current
preventive
strategies
are
limited.
Recently,
the
relationship
between
gut
microbiota
infertility
has
garnered
increasing
attention.
The
dietary
index
for
(DI-GM)
is
new
that
reflects
diversity
of
microbiota.
However,
its
association
with
female
remains
unclear.
This
cross-sectional
study
included
3,053
women
aged
18-45
years
from
National
Health
Nutrition
Examination
Survey
(NHANES)
database
2013
2018.
was
defined
based
on
responses
to
questionnaire
reproductive
health.
DI-GM
score
calculated
by
averaging
intake
two
24-h
recall
interviews.
Weighted
multivariable
logistic
regression,
restricted
cubic
splines
(RCS),
subgroup
analyses
were
used
investigate
infertility.
Based
self-reported
data,
370
participants
(12.12%)
classified
as
infertile.
A
higher
proportion
lower
scores
experienced
Multivariable
regression
analysis
indicated
negative
risk
infertility,
regardless
whether
independent
variable
analyzed
continuous
or
in
quartiles
fully
adjusted
model
(Model
3,
variable:
OR
=
0.89,
95%
confidence
interval
(CI):
0.80-0.98,
p
0.025;
Q4
vs.
Q1:
0.63,
CI
0.42-0.94,
0.032,
trend
0.013).
RCS
curves
demonstrated
non-linear
risk.
Subsequent
corroborated
robustness
these
findings.
These
findings
suggest
females,
associated
Gut
microbes
are
important
for
the
development
of
atherosclerotic
cardiovascular
disease
(ASCVD),
and
dietary
index
gut
microbiota
(DI-GM),
a
new
measure
flora-friendly
diets,
has
not
been
systematically
investigated
in
relation
to
ASCVD.
This
study
aimed
evaluate
correlation
between
DI-GM
risk
ASCVD
American
older
adults,
also
analyze
mediating
role
body
mass
(BMI).
Researchers
selected
2234
elderly
participants
≥
65
years
age
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2015
2018
cross-sectional
cohort
study.
Stratified
analyses
were
taken
based
on
quartile.
To
achieve
our
research
objectives,
we
employed
logistic
regression
analysis,
smooth
curve
fitting,
interaction
effects
mediation
analysis.
After
adjusting
confounders,
individuals
with
higher
had
significantly
lower
(highest
quartile
vs.
lowest
OR
=
0.73,
95%
CI:
0.52-1.01,
P
<
0.001).
was
linearly
negatively
associated
(P
0.13)
association
stable
diabetes
subgroup
(interaction
>
0.05),
but
age,
gender
BMI
may
modify
0.05).
mediated
11.51%
(95%
2.54%-54.1%,
0.016).
is
likely
be
promising
indicator
assessment
ASCVD,
exhibiting
partial
effect
this
association.
Future
studies
should
prioritize
comprehensive
investigation
underlying
mechanisms
by
which
contributes
atherogenesis,
aim
enhancing
efficacy
early
prevention
strategies
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
Abstract
Background
The
relationship
between
the
gut
microbiota
and
hypertension
has
gained
increasing
attention.
However,
associations
Dietary
Index
for
Gut
Microbiota
(DI-GM),
an
indicator
of
diversity,
remain
insufficiently
explored.
We
hypothesized
that
a
higher
DI-GM
score
would
be
associated
with
lower
prevalence
hypertension.
Methods
analyzed
data
from
20,283
participants
in
National
Health
Nutrition
Examination
Survey
(NHANES)
2007–2016
cycle
via
weighted
generalized
linear
models
smooth
curve
fitting
to
examine
association
Mediation
analysis
was
conducted
evaluate
role
eGFR
waist
circumference.
Results
After
adjusting
confounding
factors,
significantly
(OR
=
0.94,
95%
CI
0.92–0.97).
Compared
individuals
0–3,
those
≥
6
had
0.77,
0.69–0.86).
mediation
indicated
circumference
accounted
5.91%
3.91%,
respectively,
Conclusion
A
is
hypertension,
which
partially
mediated
by
Journal of the American Nutrition Association,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Май 18, 2025
The
aim
of
this
research
was
to
clarify
the
relationship
between
Dietary
Index
for
Gut
Microbiota
(DI-GM)
and
severity
chronic
kidney
disease
(CKD),
renal
function,
prevalence
sarcopenia
in
patients
with
CKD,
as
well
role
Systemic
Immune-Inflammation
(SII)
therein.
Using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007-2018,
study
included
2169
participants
CKD.
DI-GM
calculated
on
a
scale
0
13,
higher
scores
indicating
healthier
gut
microbiome.
CKD
categorized
by
estimated
glomerular
filtration
rate
(eGFR),
defined
using
appendicular
lean
mass
adjusted
body
index.
Statistical
analyses
weighted
regression
models,
restricted
cubic
spline,
subgroup
analysis,
mediation
analysis.
Higher
were
associated
lower
(odds
ratio
[OR],
0.85;
95%
confidence
interval
[CI],
0.78-0.94;
p
=
.001),
improved
function
(eGFR,
β
1.078,
.020;
serum
creatinine,
-1.548,
.026;
blood
urea
nitrogen,
-0.091,
.026),
reduced
(OR,
0.70;
CI,
0.57-0.87;
.002).
SII
score
partially
mediated
association
accounting
12.11%
effect
(p
<
.001).
No
significant
associations
found
all-cause
or
cardiovascular
mortality
among
population
Findings
suggest
that
dietary
interventions
targeting
microbiota
may
have
benefits
managing
severity,
improving
reducing
risk.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Май 26, 2025
Background
Hyperuricemia
(HUA)
is
a
common
metabolic
disorder,
yet
the
impact
of
diet
and
gut
microbiota
on
uric
acid
metabolism
remains
insufficiently
understood.
This
study
aims
to
investigate
relationship
between
dietary
index
for
(DI-GM)
HUA
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods
employed
NHANES
gathered
2007
2020,
encompassing
25,899
adults
aged
18
years
older.
The
DI-GM,
which
spans
0
14,
was
calculated
based
recall
information.
diagnosis
established
through
laboratory
findings.
To
examine
DI-GM
HUA,
multivariable
logistic
regression
utilized,
accounting
pertinent
confounding
variables.
Results
Upon
adjusting
possible
variables,
an
elevated
score
demonstrated
notable
correlation
with
reduced
likelihood
[odds
ratio
(OR)
=
0.968,
95%
confidence
interval
(CI)
0.949–0.987,
p
0.005].
Subjects
exhibiting
≥6
markedly
risk
in
contrast
those
scoring
3
(OR
0.897,
CI
0.821–0.980,
0.016).
Conclusion
A
higher
inversely
related
HUA.
