A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials

Gels, Год журнала: 2024, Номер 10(11), С. 693 - 693

Опубликована: Окт. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Язык: Английский

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Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway

Biomaterials, Год журнала: 2025, Номер 318, С. 123144 - 123144

Опубликована: Янв. 25, 2025

Язык: Английский

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Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications

Gels, Год журнала: 2025, Номер 11(4), С. 275 - 275

Опубликована: Апрель 6, 2025

Chitosan (CS), a versatile biopolymer obtained through the deacetylation of chitin, has gained significant interest in biomedical and pharmaceutical applications due to its biocompatibility, biodegradability, unique gel-forming capabilities. This review comprehensively analyzes CS-based gel development, covering extraction from various natural sources, gelation mechanisms, applications. Different methods, including chemical, biological, green techniques, are discussed regarding efficiency sustainability. The explores physicochemical properties CS that influence behavior, highlighting mechanisms such as physical, ionic, chemical cross-linking. Recent advances formation, Schiff base reactions, Diels–Alder click chemistry, thermosensitive gelation, have expanded applicability hydrogels. Furthermore, gels demonstrated potential wound healing, tissue engineering, drug delivery, antimicrobial applications, offering controlled release, enhanced tunable mechanical properties. incorporation nanomaterials, bioactive molecules, functional cross-linkers further improved hydrogel performance. current underscores growing significance innovative biomaterials regenerative medicine sciences.

Язык: Английский

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Preparation and Properties of Glycerohydrogels Based on Silicon Tetraglycerolate, Chitosan Hydrochloride and Glucomannan

Gels, Год журнала: 2025, Номер 11(2), С. 103 - 103

Опубликована: Фев. 2, 2025

Glycerohydrogels based on silicon glycerolate, chitosan (CS) and polyvinyl alcohol (PVA) are widely studied for use in biomedical applications. In line with the general trend of replacing synthetic polymers natural ones such compositions, it would be interest to replace PVA polysaccharide glucomannan (GM), as well introduce functional additives impart desired properties, including gelation time, final hydrogel. this work, a comprehensive study preparation conditions properties glycerohydrogels tetraglycerolate, hydrochloride (CS·HCl) GM was carried out. Viscometry used assess conformational state CS·HCl macromolecules, their associates solution before gelation. Gelation using vessel inversion method. The mucoadhesive dermoadhesive obtained were assessed tearing off method from model substrates simulating mucous dermal tissues. individual mixed estimated; intrinsic viscosity hydrodynamic radius macromolecular coils calculated. influence various factors (addition ε-aminocaproic hydrochloric acids, sodium chloride, hydroxide tetraborate vary acidity ionic strength medium, temperature) molecular weight time studied. achieved less than 2 min, which is promising practical terms, i.e., creating liquid plasters. Our best samples not inferior commercial “Metrogyl Denta”® terms force during mucoadhesion dermoadhesion at short times. Thus, synthesized by us could find usage new biopharmaceutical

Язык: Английский

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Multi-functional bioactive hydrogel based on CCM-Co-ZIF-8 nanoparticles for chronic wound healing: Synergistic antibacterial, antioxidant, and anti-inflammatory therapy

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113824 - 113824

Опубликована: Фев. 1, 2025

Язык: Английский

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Bio-inspired, programmable biomacromolecules based nanostructures driven cancer therapy

Biomaterials Advances, Год журнала: 2025, Номер 171, С. 214235 - 214235

Опубликована: Фев. 15, 2025

Язык: Английский

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4D printing polymeric biomaterials for adaptive tissue regeneration

Bioactive Materials, Год журнала: 2025, Номер 48, С. 370 - 399

Опубликована: Фев. 22, 2025

Язык: Английский

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Evaluation of the effect of grape seed extract loaded-chitosan nanoparticles on cryptosporidiosis in dexamethasone immunosuppressed male mice

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141513 - 141513

Опубликована: Фев. 1, 2025

Язык: Английский

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Hydrogel-Based Inks for Extrusion 3D Printing: A Rheological Viewpoint

Current Opinion in Colloid & Interface Science, Год журнала: 2025, Номер unknown, С. 101918 - 101918

Опубликована: Март 1, 2025

Язык: Английский

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Targeted delivery of Zingiber officinale Roscoe extract-loaded chitosan nanoparticles for inhibition of multidrug-resistant Escherichia coli-induced HCT-116 colon cancer

Clinical Phytoscience, Год журнала: 2025, Номер 11(1)

Опубликована: Март 27, 2025

Abstract The emergence of multidrug-resistant ( MDR ) Escherichia coli E. is a growing concern, as it significantly contributes to colon cancer initiation and progression. Conventional treatment strategies face challenges such poor bioavailability antibiotic resistance, necessitating the development targeted therapies. This study evaluates efficacy Zingiber officinale Roscoe (ginger) extract-loaded chitosan nanoparticles GELCs in inhibiting -induced using HCT-116 cell line. were synthesized with an average size 150 ± 5 nm, zeta potential + 32.5 mV, encapsulation efficiency 84.3%. Their biological activity was assessed through vitro vivo models, focusing on antimicrobial effects, cytotoxicity, apoptosis induction, inflammatory modulation. exhibited potent activity, reducing colony-forming units (CFUs) by 83% compared untreated co-cultures. MTT assay results showed dose-dependent reduction viability, IC₅₀ 22.8 µg/mL , which lower than that free ginger extract (IC₅₀ = 48.6 µg/mL), indicating enhanced efficacy. Flow cytometry analysis confirmed increased apoptosis, BAX/BCl-2 ratio 11.3 GELC -treated group 1.0 control . ELISA assays further demonstrated cytokines, IL-6, TNF-α, IL-1β levels decreasing 54%, 61%, 47% respectively. These findings highlight dual anticancer making them promising candidate for therapy against -associated cancer. underscores advantages nanoparticle-based delivery systems enhancing therapeutic natural bioactive compounds.

Язык: Английский

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