Structure-Based Insights into Fatty Acid Modulation of Lipid-Sensing Nuclear Receptors PPARδ/γ for Glycemic Regulation

Aspects of Molecular Medicine, Год журнала: 2025, Номер unknown, С. 100079 - 100079

Опубликована: Март 1, 2025

Язык: Английский

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Synthesis Development, Spectroscopy Characterizations, and Molecular Docking Study of Some New Bis-1,3-Oxazepine and Bis-1,3-Benzoxazepine Derivatives

Oriental Journal Of Chemistry, Год журнала: 2025, Номер 41(2), С. 563 - 572

Опубликована: Апрель 28, 2025

Several novel Bis-Oxazepine and Bis-Benzoxazepine derivatives have been produced by condensation cyclization processes over two effective practical stages. The first stage involved utilizing the Dean-Stark apparatus to create imine intermediates through reactions of 3-hydroxy benzaldehyde with various aromatic diamine substrates in presence glacial acetic acid as a catalyst. second required treatment bis-Schiff base intermediate maleic- or phthalic anhydride dry benzene produce desired 70-95% yields using microwave irradiation. molecular docking chemicals was conducted against progesterone receptor. results indicate potential anticancer properties for three compounds, which show most promising findings. These compounds obtained higher scores (ΔG −9.58, −9.28, −9.11 kcal/mol), forming hydrogen bonds target protein.

Язык: Английский

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Novel triazole-tethered thiazol-4(5H)-one hybrids as potential therapeutics for obesity and type 2 diabetes: in vitro, in vivo, and in silico evaluations

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142577 - 142577

Опубликована: Май 1, 2025

Язык: Английский

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Computational design and molecular insights into acetylcholinesterase inhibitors from Aristolochia indica for Alzheimer’s disease therapy

Discover Chemistry., Год журнала: 2025, Номер 2(1)

Опубликована: Май 24, 2025

Язык: Английский

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