Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер unknown, С. 189238 - 189238
Опубликована: Дек. 1, 2024
Язык: Английский
Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 754, С. 151526 - 151526
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
2
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер 106, С. 106696 - 106696
Опубликована: Фев. 6, 2025
Язык: Английский
Процитировано
1
Life Sciences, Год журнала: 2025, Номер unknown, С. 123472 - 123472
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Cosmetics, Год журнала: 2025, Номер 12(1), С. 9 - 9
Опубликована: Янв. 13, 2025
This study addresses a significant gap in the clinical validation and standardization of exosome-based applications within domains cosmetics regenerative medicine. Despite offering thorough overview potential therapeutic benefits underlying mechanisms exosomes, manuscript underscores several unresolved challenges, including paucity evidence, regulatory barriers, inconsistencies standardization, incomplete mechanistic understanding. The primary aim this research is to conduct systematic comprehensive review existing studies on exosomes skincare. To achieve this, literature was performed, drawing major medical database PubMed. approach facilitated collection meta-analysis relevant data, ensuring rigorous assessment recent advancements exosome research. main outcomes highlight multifaceted roles promoting skin rejuvenation mitigating signs aging. Specific discussed include pigmentation correction, wound healing, tissue repair, innovative delivery mechanisms. Moreover, examines emerging plastic surgery Challenges limitations, such as constraints, hurdles, need for further validation, are critically analyzed, providing framework future directions.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2025, Номер 93, С. 102749 - 102749
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 326 - 326
Опубликована: Март 3, 2025
Exosomes, spherical lipid-bilayered particles secreted by cells, have recently emerged as a novel and highly promising drug delivery system, attracting extensive attention in the field of biomedical research. Dendritic-cell-derived exosomes (DC-Exos) possess surface protein ligands characteristic DC such functional MHC-I MHC-II, CD80, CD86. These components play crucial role immune responses, facilitating antigen uptake, presentation, activation antigen-specific CD4 CD8 T cells. properties make them striking excellent vehicles for use various diseases cancer therapy. This review summarizes discusses characteristics, current methods types loading DC-Exos. Its modifications application disease treatment were also discussed, aiming to motivate development exosome-based theranostic nanoplatforms nanotechnology improved healthcare treatments.
Язык: Английский
Процитировано
0
Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Apigenin, a widely distributed bioactive flavonoid, has recently gained excellent attention among researchers as an effective anticancer drug that can alternate cancer signaling pathways, induce programmed cell death, and reduce tumor growth in various types. Despite its impressive anti-neoplastic activity, high hydrophobicity nonspecific biodistribution make apigenin difficult for pharmaceutical application. We highlighted the therapeutic potential of derivatives different types, along with their mechanism action. Nanoengineered delivery systems have remarkable applications minimizing degradation enhancing efficacy drugs sustained release, prolonged blood retention time, reduced off-target toxicities. This review evaluated explored molecular interactions this novel flavonoid pathways to selectively inhibit neoplastic development multiple To ensure complete coverage research area, google scholar, PubMed, web science were used find not only most relevant, but also connected similar articles. A comprehensive overview nanotherapy treatment establish platform overcome difficulties application efficient clinical translation from bench bedside.
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2025, Номер 17(6), С. 940 - 940
Опубликована: Март 10, 2025
Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2491 - 2491
Опубликована: Март 11, 2025
Exosomes, which are nano-sized natural vesicles secreted by cells, crucial for intercellular communication and interactions, playing a significant role in various physiological pathological processes. Their characteristics, such as low toxicity immunogenicity, high biocompatibility, remarkable drug delivery capabilities—particularly their capacity to traverse the blood–brain barrier—make exosomes highly promising vehicles administration treatment of brain disorders. This review provides comprehensive overview exosome biogenesis isolation techniques, strategies loading functionalization exosomes, exosome-mediated barrier penetration mechanisms, with particular emphasis on recent advances exosome-based Finally, we address opportunities challenges associated utilizing system brain, summarizing barriers clinical translation proposing future research directions.
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(7), С. 548 - 548
Опубликована: Апрель 4, 2025
Extracellular vesicles (EVs) have been explored as promising vehicles for drug delivery. One of the most valuable features EVs is their ability to cross physiological barriers, particularly blood–brain barrier (BBB). This significantly enhances development EV-based delivery systems treatment CNS disorders. The present review focuses on factors and techniques that contribute successful therapeutics brain. Here, we discuss major methods brain targeting which includes utilization different administration routes, capitalizing biological origins EVs, modification through addition specific ligands surface EVs. Finally, current challenges in large-scale EV production loading while highlighting future perspectives regarding application
Язык: Английский
Процитировано
0