Engineering Colloidal Nanozymes for Cancer Diagnosis and Therapy: From Surface Chemistry to Catalytic Mechanisms and Precision Medicine DOI
Mohammed Ali Dheyab, Azlan Abdul Aziz, Wesam Abdullah

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Colloidal nanozymes, enzyme-mimetic nanocatalysts with tunable catalytic activity, are revolutionizing cancer diagnosis and therapy by integrating precision biomedical functionality. Their ability to regulate redox homeostasis, generate reactive oxygen species (ROS), modulate tumor microenvironments provides a foundation for targeted therapeutic interventions, while their intrinsic properties enhance biosensing imaging early detection. However, the rational design of nanozymes remains challenge, particularly in optimizing efficiency, biocompatibility, specificity tumor-selective reactions. This review explores how surface chemistry, interfacial engineering, mechanisms dictate nanozyme stability, interactions biological systems. We critically analyze fundamental peroxidase-like, oxidase-like, catalase-like, superoxide dismutase (SOD)-like reactions driving applications therapy, as well role biosensors, probes, theranostic platforms diagnosis. Additionally, we examine cutting-edge modification strategies, including atomic dispersion, ligand coordination, defect selectivity reduce off-target effects. By catalysis translational applications, this establishes comprehensive framework advancing nanozyme-based diagnostics therapeutics oncology.

Язык: Английский

A Comprehensive Review on the Synthesis and Therapeutic Potential of Cobalt Ferrite (CoFe2O4) Nanoparticles DOI Creative Commons

Kishika Arora,

Lalita Ledwani,

Komal Komal

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 1, 2025

Abstract The field of nanotechnology is witnessing a remarkable surge in research and applications across various domains, showcasing exponential growth. Considerable progress has been made the advancement novel techniques for synthesis magnetic nanoparticles (MNPs) with enhanced features. Within this realm, spinel nanoferrites have gained attention due to their significant characteristics, such as increased responsiveness, improved stability biological environments, ease synthesis, surface modification capabilitiesmaking them highly applicable diverse domains. Cobalt ferrite are considered one most investigated MNPs within range. Owing distinct physical, chemical, properties, CoFe₂O₄ NPs emerged potential candidates realm biomedical applications, highlighting suitability innovative healthcare solutions. For considerable period, limited effectiveness current cancer treatment methods chemotherapy radiotherapy posed many challenges side effects. This prompted need development new technologies by incorporating functional nanomaterials that showed substantial efficacy effective strategies treating cancer. comprehensive review, therefore, introduces prominent synthesizing these ferrites particularly focusing on anticancerand antibacterial properties exhibited cobalt nanoparticles.

Язык: Английский

Процитировано

1
Eco-friendly Nanomaterials in White Analytical Chemistry: Design, Role and Implications DOI

Ghazanfar Hussain,

Rüstem Keçili, Chaudhery Mustansar Hussain

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118285 - 118285

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Extraction of biomolecular polyphenols for nanoparticles fabrication: Mechanistic insights environmental mitigation DOI
Kamalesh Sen, Shovan Mondal

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114682 - 114682

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Engineering Colloidal Nanozymes for Cancer Diagnosis and Therapy: From Surface Chemistry to Catalytic Mechanisms and Precision Medicine DOI
Mohammed Ali Dheyab, Azlan Abdul Aziz, Wesam Abdullah

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Colloidal nanozymes, enzyme-mimetic nanocatalysts with tunable catalytic activity, are revolutionizing cancer diagnosis and therapy by integrating precision biomedical functionality. Their ability to regulate redox homeostasis, generate reactive oxygen species (ROS), modulate tumor microenvironments provides a foundation for targeted therapeutic interventions, while their intrinsic properties enhance biosensing imaging early detection. However, the rational design of nanozymes remains challenge, particularly in optimizing efficiency, biocompatibility, specificity tumor-selective reactions. This review explores how surface chemistry, interfacial engineering, mechanisms dictate nanozyme stability, interactions biological systems. We critically analyze fundamental peroxidase-like, oxidase-like, catalase-like, superoxide dismutase (SOD)-like reactions driving applications therapy, as well role biosensors, probes, theranostic platforms diagnosis. Additionally, we examine cutting-edge modification strategies, including atomic dispersion, ligand coordination, defect selectivity reduce off-target effects. By catalysis translational applications, this establishes comprehensive framework advancing nanozyme-based diagnostics therapeutics oncology.

Язык: Английский

Процитировано

0