Mixed-valence vanadium-doped mesoporous bioactive glass for treatment of tumor-associated bone defects

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Vanadium is a bioactive trace element with variable valence. Its pentavalent form has been confirmed to be capable of predominantly regulating the early and mid-stage osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) without tumor inhibition, while its tetravalent exhibits inhibition but only primarily modulates late angiogenesis. In this study, multifunctional tissue scaffold consisting mixed-valence vanadium-doped mesoporous glass poly(lactic-co-glycolic acid) (V(IV/V)-MBG/PLGA) was developed simultaneously inhibit recurrence osteosarcoma promote regeneration operative defects. The in vitro results showed that V(IV) V(V) species could sustainably released from V(IV/V)-MBG complementarily enhance proliferation, differentiation, mineralization BMSCs by activating multiple signaling pathways throughout whole osteogenesis process. More importantly, co-existence mixed-valent vanadium able continuously stimulate generation excessive ROS depletion GSH synergistically supplying an appropriate ratio thermodynamically kinetically maintain stable self-circulation valence state alteration, thus inducing UMR-106 cell death. rat model, V(IV/V)-MBG/PLGA scaffolds effectively suppressed invasion promoted regeneration. These suggest are promising strategy for treating tumor-associated defects, offering dual

Язык: Английский

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DFT study on VOC detection by Helicobacter pylori using encapsulated and mono-doped gold and silver anchored fullerene C60

Nano-Structures & Nano-Objects, Год журнала: 2025, Номер 41, С. 101449 - 101449

Опубликована: Фев. 1, 2025

Язык: Английский

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Folic acid functionalization of rGO/Co3O4/Chitosan based biocompatible nanocomposite enhances targeted delivery and cytotoxicity of Doxorubicin

Composites Communications, Год журнала: 2025, Номер unknown, С. 102362 - 102362

Опубликована: Март 1, 2025

Язык: Английский

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Advanced nanocomposite-based electrochemical sensor for ultra-sensitive dopamine detection in physiological fluids

Frontiers in Lab on a Chip Technologies, Год журнала: 2025, Номер 4

Опубликована: Март 25, 2025

This study presents a novel point-of-care electrochemical sensor for dopamine (DA) detection, featuring flexible laser-induced graphene (LIG) modified with unique nanocomposite comprising Nb 4 C 3 T x MXene, polypyrrole (PPy), and iron nanoparticles (FeNPs). The LIG-Nb MXene-PPy-FeNPs is characterized by scanning electron microscopy to confirm the successful surface modification. performance of fabricated via cyclic voltammetry showed significant activity upon modification LIG an increased peak anodic current (I pa ) from 43 μA 104 μA. demonstrated high electrocatalytic wide linear detection range 1 nM mM DA excellent sensitivity 0.283 μA/nM cm −2 , ultralow limit 70 pM. exhibited good recovery in biological samples remarkable selectivity DA, effectively distinguishing it common interfering compounds such as uric acid, ascorbic glucose, sodium chloride, their mixtures. platform provides reliable accurate approach detecting even complex matrices at applications highlighting its potential advanced biosensing applications.

Язык: Английский

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Tissue adhesives based on chitosan for biomedical applications

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Chitosan bio-adhesives bond strongly with various biological tissues, such as skin, mucosa, and internal organs.

Язык: Английский

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Foliar application of zinc oxide (ZnO) nanoparticles ameliorates growth, yield traits, osmolytes, cell viability, and antioxidant system of Brassica juncea (L.) Czern. grown in lead (Pb) stress

Chemosphere, Год журнала: 2024, Номер 370, С. 143950 - 143950

Опубликована: Дек. 17, 2024

Язык: Английский

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Exploring the Bioactivity and Antibacterial Properties of Silver and Cerium Co-Doped Borosilicate Bioactive Glass

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Bone defects resulting from trauma or diseases that lead to bone loss have created a growing need for innovative materials suitable treating bone-related conditions.

Язык: Английский

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Integrating Physical and Biochemical Cues for Muscle Engineering: Scaffolds and Graft Durability

Bioengineering, Год журнала: 2024, Номер 11(12), С. 1245 - 1245

Опубликована: Дек. 9, 2024

Muscle stem cells (MuSCs) are essential for skeletal muscle regeneration, influenced by a complex interplay of mechanical, biochemical, and molecular cues. Properties the extracellular matrix (ECM) such as stiffness alignment guide cell fate through mechanosensitive pathways, where forces like shear stress translate into biochemical signals, affecting behavior. Aging introduces senescence which disrupts MuSC niche, leading to reduced regenerative capacity via epigenetic alterations metabolic shifts. Transplantation further challenges viability, often resulting in fibrosis driven dysregulated fibro-adipogenic progenitors (FAPs). Addressing these issues, scaffold designs integrated with pharmacotherapy emulate ECM environments, providing cues that enhance graft functionality endurance. These scaffolds facilitate synergy between mechanotransduction intracellular signaling, optimizing proliferation differentiation. Innovations utilizing human pluripotent cell-derived myogenic exosome-mediated delivery exploit bioactive properties targeted repair. Additionally, 3D-printed electrospun adjustable biomechanical traits tackle scalability treating volumetric loss. Advanced techniques single-cell RNA sequencing high-resolution imaging unravel repair mechanisms, offering precise mapping cellular interactions. Collectively, this interdisciplinary approach fortifies tissue durability maintenance, propelling therapeutic strategies injuries degenerative diseases.

Язык: Английский

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Acid-responsive CST@NPs enhanced diabetic wound healing through rescuing mitochondrial dysfunction

Bioactive Materials, Год журнала: 2024, Номер 44, С. 269 - 282

Опубликована: Окт. 23, 2024

Язык: Английский

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Toxicology of Nanomaterials With a Special Focus on the Nervous System

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Год журнала: 2024, Номер unknown, С. 27 - 64

Опубликована: Окт. 11, 2024

Nanomaterials possess different properties that make them suitable for application in numerous fields. Nonetheless, their toxicity, especially neurotoxic propensity, is a considerable area of investigation. In this chapter, nanomaterial neurotoxicity reviewed detail, with an emphasis on assessing levels exposure or routes entry to brain cells, mechanisms by which they cause damage, and specific types damage. addition, vitro, ex vivo, vivo models used measure are described. This chapter provides discussion matter considering challenges terms characterization, risk assessment, regulatory aspects. concludes underscoring the importance toxicological prediction safe-by-design solutions. Future research should address long-term effects using nanomaterials means preventing neurotoxicity.

Язык: Английский

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