Characterizing Absolute Orientations in DNA Self-Assembly of Single Molecules DOI
Keitel Cervantes‐Salguero, Madison Kadrmas,

William C. Clay

и другие.

The Journal of Physical Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

DNA self-assembly of single molecules (i.e., dyes) with deterministic orientations is a powerful approach for engineering molecular excitons. However, current determination methods the dye orientation relative to do not account plane, which missing degree freedom needed define absolute three-dimensional orientations. In this work, we combine fluorescence-detected linear dichroism, defocused dipole imaging, and point accumulation imaging in nanoscale topography (DNA-PAINT) super-resolution microscopy determine Cy5 dyes host duplexes, includes plane orientation. The data revealed that absorption emission dipoles are perpendicular duplex, mean parallel bases, supports notion intercalate between base pairs. presented methodology will inspire investigation controlling arrangement configurations beyond spontaneous π-stacking as well achieving novel dye-DNA arrangements.

Язык: Английский

Distinguishing packing configurations of molecular dimers using excited-state absorption peaks in two-dimensional electronic spectra DOI
Matthew S. Barclay, Paul D. Cunningham, Gissela Pascual

и другие.

The Journal of Chemical Physics, Год журнала: 2025, Номер 162(17)

Опубликована: Май 1, 2025

Packing conformations of molecular aggregates are known to strongly influence the locations and intensities spectral peaks. Here, we develop third-order nonlinear spectroscopy signals for a purely electronic model dimer, which is prototype aggregate system. The model-which focuses on excited-state absorption (ESA) pathways in two-dimensional spectra-reveals that orientational averaging leads diagnostic ESA peak H- J-dimers. We constructed DNA-templated dimers cyanine molecules as representative systems used ultrabroadband measurements support predicted signatures arising from theoretical model. Fitting steady-state spectra supports assigned packing conformations. results elucidate how peaks can be conformation. This work lays foundation future studies include complicating effects vibronic states additional levels.

Язык: Английский

Процитировано

0

Characterizing Absolute Orientations in DNA Self-Assembly of Single Molecules DOI
Keitel Cervantes‐Salguero, Madison Kadrmas,

William C. Clay

и другие.

The Journal of Physical Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

DNA self-assembly of single molecules (i.e., dyes) with deterministic orientations is a powerful approach for engineering molecular excitons. However, current determination methods the dye orientation relative to do not account plane, which missing degree freedom needed define absolute three-dimensional orientations. In this work, we combine fluorescence-detected linear dichroism, defocused dipole imaging, and point accumulation imaging in nanoscale topography (DNA-PAINT) super-resolution microscopy determine Cy5 dyes host duplexes, includes plane orientation. The data revealed that absorption emission dipoles are perpendicular duplex, mean parallel bases, supports notion intercalate between base pairs. presented methodology will inspire investigation controlling arrangement configurations beyond spontaneous π-stacking as well achieving novel dye-DNA arrangements.

Язык: Английский

Процитировано

0