NIR II Laser-Triggered Photothermal Nanoplatform for Multimodal Imaging-Guided Synergistic Therapy toward Colon Cancer
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Colon
cancer
is
one
kind
of
malignant
digestive
tract
tumor
with
high
morbidity
and
mortality
worldwide,
treatments
for
which
still
face
great
challenges.
Recently
emerged
intervention
strategies
such
as
phototherapy
gas
therapy
have
displayed
promising
effects
in
the
treatment
colon
cancer,
but
their
application
are
hindered
due
to
insufficient
targeting
deeper
tissue
penetrating
capacity.
Herein,
present
study,
we
developed
theranostic
nanoplatform
Cet-CDs-SNO
(CCS)
realize
multimodal
imaging-guided
synergistic
therapy.
Among
CCS,
Cetuximab
(Cet),
first-line
clinical
drugs
colorectal
endowed
CCS
tumor-targeting
capacity
enhanced
drug
accumulation
cells;
CDs
doped
by
Ni2+
Mn2+
served
NIR-II
photothermal
(PTT),
chemodynamic
(CDT),
photothermal/magnetic
resonance/fluorescence
imaging
(PTI/MRI/FLI)
agents;
SNO,
a
nitric
oxide
(NO)
donor,
exerted
therapeutic
(GT)
under
thermal
stimulation
derived
from
PTT.
In
vitro
vivo
experiments
proved
that
had
excellent
cancer-targeting
ability.
Proliferation
cells
growth
were
significantly
inhibited
administration
without
detectable
cytotoxicity.
This
study
presented
strategy
developing
multifunctional
be
applied
precise
Язык: Английский
Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment
Nanoscale,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Achieving
accurate
and
efficient
tumor
imaging
is
crucial
in
the
field
of
treatment,
as
it
facilitates
early
detection
precise
localization
tissues,
thereby
informing
therapeutic
strategies
surgical
interventions.
The
optical
technology
within
second
near-infrared
(NIR-II)
window
has
garnered
significant
interest
for
its
remarkable
benefits,
such
enhanced
tissue
penetration
depth,
superior
signal-to-background
ratio
(SBR),
minimal
autofluorescence,
reduced
photon
attenuation,
lower
scattering.
This
review
explained
design
optimization
nano-agents
responsive
to
NIR-II
window,
single-walled
carbon
nanotubes,
quantum
dots,
lanthanum-based
nanomaterials,
noble
metal
nanomaterials.
These
enable
non-invasive,
deep-tissue
with
high
spatial
resolution
their
properties
significantly
improve
accuracy,
efficiency,
versatility
imaging-guided
treatments.
And
we
discussed
characteristics
advantages
fluorescence
(FL)/photoacoustic
(PA)
providing
a
comprehensive
overview
latest
research
progress
different
FL/PA
therapy.
Furthermore,
exhaustively
reviewed
applications
multifunctional
nano-phototherapy
technologies
carried
out
by
light
including
photothermal
therapy
(PTT),
photodynamic
(PDT),
combined
modalities
like
photothermal-chemodynamic
(PTT-CDT),
photothermal-chemotherapy
(PTT-CT),
photothermal-
immunotherapy
(PTT-IO).
integrated
approaches
have
gradually
matured
over
past
decade
are
expected
become
safe
effective
non-invasive
treatment.
Finally,
outlined
prospects
challenges
development
innovation
diagnosis
nanoplatform.
aims
provide
insightful
perspectives
future
advancements
treatment
platforms.
Язык: Английский
Thermo-Responsive Gold Nanorod Vesicles for Combined NIR-II Photothermal Therapy and Chemotherapy of Solid Tumors
Acta Biomaterialia,
Год журнала:
2024,
Номер
192, С. 353 - 365
Опубликована: Ноя. 26, 2024
Язык: Английский
Advances in Photothermal and Photodynamic Nanotheranostics for Precision Cancer Treatment
Journal of Nanotheranostics,
Год журнала:
2024,
Номер
5(4), С. 228 - 252
Опубликована: Дек. 13, 2024
Nanotheranostics,
combining
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
can
transform
precision
cancer
treatment
by
integrating
diagnosis
into
a
single
platform.
This
review
highlights
recent
advances
in
nanomaterials,
drug
delivery
systems,
stimuli-responsive
mechanisms
for
effective
PTT
PDT.
Multifunctional
nanoparticles
enable
targeted
delivery,
multimodal
imaging,
controlled
release,
overcoming
the
challenges
posed
tumor
microenvironments.
Emerging
approaches
such
as
hybrid
therapies
immune
activation
further
enhance
therapeutic
efficacy.
paper
discusses
limitations
of
nanotheranostics,
including
synthesis
complexity
limited
tissue
penetration,
explores
future
directions
toward
biocompatible,
scalable,
clinically
translatable
solutions.
Язык: Английский