Bioactive Materials, Год журнала: 2024, Номер 46, С. 347 - 364
Опубликована: Дек. 27, 2024
Язык: Английский
Bioactive Materials, Год журнала: 2024, Номер 46, С. 347 - 364
Опубликована: Дек. 27, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 128 - 144
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
7Chemical Communications, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.
Язык: Английский
Процитировано
4ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Coating biological membranes onto biomimetic nanocarriers improves biocompatibility, prolongs circulation, and enhances targeted delivery for cancer precision medicine. To better understand the biodistribution profiles of these nanosystems, molecular imaging techniques, including optical imaging, radionuclide magnetic resonance ultrasound have been widely employed in vivo tracking dynamic imaging. Here this review, we delve into profound role modalities visualizing changes tumor microenvironment, particularly monitoring oxygen consumption immune response dynamics, highlighting their potential to improve therapies. We also briefly discuss current applications synergistic therapies future perspectives. Finally, offer insights integrating nanomedicine with clinical translation.
Язык: Английский
Процитировано
0ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 11, 2025
Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Апрель 29, 2025
Язык: Английский
Процитировано
0Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
Elesclomol (ES) as an efficient Cu ionophore can specifically transport into mitochondria and disrupt intracellular homeostasis. Extra induces cuproptosis chemodynamic therapy (CDT), which further cascades immunogenic cell death (ICD) activates antitumor immune responses. However, the tumor immunosuppressive microenvironment (TIM) attenuates efficiency of response. Herein, a biomimic nanodrug (ECNM) is fabricated, ES,
Язык: Английский
Процитировано
1Bioactive Materials, Год журнала: 2024, Номер 46, С. 347 - 364
Опубликована: Дек. 27, 2024
Язык: Английский
Процитировано
1