From bench to bedside: Platelet biomimetic nanoparticles as a promising carriers for personalized drug delivery

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 128 - 144

Опубликована: Июль 14, 2024

Язык: Английский

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Targeting Sub-Cellular Organelles for Boosting Precision Photodynamic Therapy

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.

Язык: Английский

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Molecular Imaging for Biomimetic Nanomedicine in Cancer Therapy: Current Insights and Challenges

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Coating biological membranes onto biomimetic nanocarriers improves biocompatibility, prolongs circulation, and enhances targeted delivery for cancer precision medicine. To better understand the biodistribution profiles of these nanosystems, molecular imaging techniques, including optical imaging, radionuclide magnetic resonance ultrasound have been widely employed in vivo tracking dynamic imaging. Here this review, we delve into profound role modalities visualizing changes tumor microenvironment, particularly monitoring oxygen consumption immune response dynamics, highlighting their potential to improve therapies. We also briefly discuss current applications synergistic therapies future perspectives. Finally, offer insights integrating nanomedicine with clinical translation.

Язык: Английский

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Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.

Язык: Английский

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Genetically Engineered T Cell Membrane-Camouflaged Nanoparticles Triggered Cuproptosis for Synergistic Bladder Cancer Photothermal-Immunotherapy

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Immunotherapy has become a promising and transformative approach for treating advanced or treatment-resistant bladder cancer (BCa). However, its efficacy remains limited due to the immunosuppressive tumor microenvironment (TME) insufficient immune cell infiltration. Photothermal therapy (PTT), which could cause immunogenic death (ICD) in tissue, been explored as synergistic immunotherapy. Yet, thermal resistance cells often undermines effectiveness of PTT. To address these challenges, we proposed novel strategy that combines PTT with cuproptosis, recently identified form ICD, by engineering Tim-3-overexpressing T membrane-coated nanoparticles (Tim3@PHSM@IC) enhance BCa The overexpression Tim-3 on membrane enabled precise targeting competitively inhibited receptor through recognition Galectin-9. In vitro, Tim3@PHSM@IC effectively induced photothermal cytotoxicity robust cuproptosis. vivo, significantly growth multiple mouse models. Flow cytometry (FCM) RNA sequencing (RNA-seq) analyses revealed reprogrammed TME activating immune-related genes enhancing ICD This study highlights potential overcoming improving immunotherapy integrating

Язык: Английский

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Biomimic Nanodrugs Overcome Tumor Immunosuppressive Microenvironment to Enhance Cuproptosis/Chemodynamic‐Induced Cancer Immunotherapy

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

Elesclomol (ES) as an efficient Cu ionophore can specifically transport into mitochondria and disrupt intracellular homeostasis. Extra induces cuproptosis chemodynamic therapy (CDT), which further cascades immunogenic cell death (ICD) activates antitumor immune responses. However, the tumor immunosuppressive microenvironment (TIM) attenuates efficiency of response. Herein, a biomimic nanodrug (ECNM) is fabricated, ES,

Язык: Английский

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Fabrication and functional validation of a hybrid biomimetic nanovaccine (HBNV) against Kit-mutant melanoma

Bioactive Materials, Год журнала: 2024, Номер 46, С. 347 - 364

Опубликована: Дек. 27, 2024

Язык: Английский

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