Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities
Cancers,
Год журнала:
2025,
Номер
17(4), С. 701 - 701
Опубликована: Фев. 19, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
that
has
bleak
outlook
despite
existing
treatments
such
as
surgery,
radiation,
and
chemotherapy.
The
utilization
of
nanoparticles
for
drug
delivery
presents
promising
method
by
which
to
improve
the
effectiveness
treatment
while
reducing
harmful
effects
on
entire
body.
This
review
examines
application
in
GBM,
focusing
different
types
nanoparticles,
including
lipid-based,
polymeric,
metallic,
those
under
development.
Every
variety
analyzed
its
distinct
characteristics
therapeutic
capacity.
Lipid-based
liposomes
solid
lipid
enhance
transport
medicines
are
not
soluble
water
have
shown
considerable
potential
preclinical
investigations.
Polymeric
benefits
terms
controlled
release
targeted
distribution,
whereas
metallic
both
therapy
imaging.
In
current
we
would
like
emphasize
ways
medicine
delivery,
specifically
enhancing
penetration
blood-brain
barrier
(BBB),
targeting
tumors,
enabling
release.
Additionally,
also
discuss
clinical
discoveries,
highlighting
achievements
obstacles
process
converting
these
technologies
into
effective
GBM.
study
offers
thorough
examination
present
status
prospects
Язык: Английский
Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Abstract
Glioblastoma
multiforme
(GBM)
is
one
of
the
most
lethal
malignant
brain
tumors
in
central
nervous
system.
Patients
face
many
challenges
after
surgery,
including
tumor
recurrence,
intracranial
pressure
increase
due
to
cavitation,
and
limitations
associated
with
immediate
postoperative
oral
chemotherapy.
Here
an
injected
peptide
gel
situ
immunostimulatory
functions
developed
coordinate
regulation
glutamine
metabolism
chemodynamic
therapy
for
overcoming
these
obstacles.
The
methodology
entails
crafting
injectable
scaffolds
short
molecules,
incorporating
glutaminase
inhibitor
CB‐839
copper
self‐assembled
particles
(Cu‐His
NPs)
renowned
their
(CDT)
efficacy.
By
fine‐tuning
glutamic
acid
production
via
metabolic
pathways,
this
system
not
only
heightens
therapeutic
prowess
CDT
but
also
escalates
intracellular
oxidative
stress.
This
dual
mechanism
culminates
augmented
immunogenic
cell
death
within
glioblastoma
cells
improves
a
conducive
immune
microenvironment.
Based
on
concept
reprogramming,
treatment
strategy
has
great
potential
significantly
reduce
GBM
recurrence
prolong
median
survival
murine
models.
Язык: Английский
Innovative drug delivery strategies for targeting glioblastoma: overcoming the challenges of the tumor microenvironment
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 15, 2024
Introduction
-
Glioblastoma
multiforme(GBM)
presents
a
challenging
endeavor
in
therapeutic
management
because
of
its
highly
aggressive
tumor
microenvironment(TME).
This
complex
TME,
characterized
by
hypoxia,
nutrient
deprivation,
immunosuppression,
stromal
barriers,
increased
interstitial
fluid
pressure
and
the
presence
blood-brain
barrier(BBB),
frequently
compromises
efficacy
promising
strategies.
Consequently,
deeper
understanding
TME
development
innovative
methods
to
overcome
associated
challenges
are
essential
for
improving
treatment
outcomes
GBM.
Язык: Английский
Role of UFMylation in tumorigenesis and cancer immunotherapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 23, 2024
Protein
post-translational
modifications
(PTMs)
represent
a
crucial
aspect
of
cellular
regulation,
occurring
after
protein
synthesis
from
mRNA.
These
modifications,
which
include
phosphorylation,
ubiquitination,
acetylation,
methylation,
glycosylation,
Sumoylation,
and
palmitoylation,
play
pivotal
roles
in
modulating
function.
PTMs
influence
localization,
stability,
interactions,
thereby
orchestrating
variety
processes
response
to
internal
external
stimuli.
Dysregulation
is
linked
spectrum
diseases,
such
as
cancer,
inflammatory
neurodegenerative
disorders.
UFMylation,
type
PTMs,
has
recently
gained
prominence
for
its
regulatory
role
numerous
processes,
including
stress,
key
signaling
pathways
influencing
functions.
This
review
highlights
the
function
UFMylation
development
progression
tumors,
underscoring
potential
therapeutic
target.
Moreover,
we
discuss
tumorigenesis
malignant
progression,
explore
impact
on
cancer
immunotherapy.
The
article
aims
provide
comprehensive
overview
biological
functions
propose
how
targeting
could
enhance
effectiveness
immunotherapy
strategies.
Язык: Английский
The Importance of Biotinylation for the Suitability of Cationic and Neutral Fourth-Generation Polyamidoamine Dendrimers as Targeted Drug Carriers in the Therapy of Glioma and Liver Cancer
Molecules,
Год журнала:
2024,
Номер
29(18), С. 4293 - 4293
Опубликована: Сен. 10, 2024
In
this
study,
we
hypothesized
that
biotinylated
and/or
glycidol-flanked
fourth-generation
polyamidoamine
(PAMAM
G4)
dendrimers
could
be
a
tool
for
efficient
drug
transport
into
glioma
and
liver
cancer
cells.
For
purpose,
native
PAMAM
(G4)
dendrimers,
(G4B),
glycidylated
(G4gl),
(G4Bgl),
were
synthesized,
their
cytotoxicity,
uptake,
accumulation
in
vitro
vivo
studied
relation
to
the
mediated
by
sodium-dependent
multivitamin
transporter
(SMVT).
The
studies
showed
human
temozolomide-resistant
cell
line
(U-118
MG)
hepatocellular
carcinoma
(HepG2)
indicated
higher
amount
of
SMVT
than
HaCaT
keratinocytes
(HaCaTs)
used
as
model
normal
G4gl
G4Bgl
highly
biocompatible
(they
did
not
affect
proliferation
mitochondrial
activity)
against
U-118
MG
cells
(against
Язык: Английский
An Exploration into the Current Application Status and Prospects of Nanorobots in Orthopedic Diseases Based on Their Medical Functions
Nano Biomedicine and Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Metabolically‐Driven Active Targeting of Magnetic Nanoparticles Functionalized with Glucuronic Acid to Glioblastoma: Application to MRI‐Tracked Magnetic Hyperthermia Therapy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Abstract
Glioblastoma
continues
to
pose
a
major
global
health
challenge
due
its
incurable
nature.
The
need
for
new
strategies
combat
this
devastating
tumor
is
therefore
paramount.
Nanotechnology
offers
unique
opportunities
develop
innovative
and
more
effective
therapeutic
approaches.
However,
most
nanosystems
developed
treat
glioblastomas,
especially
those
based
on
metallic
nanoparticles
(NPs),
have
proven
unsuccessful
their
inability
efficiently
target
these
tumors,
which
are
particularly
inaccessible
the
restrictions
imposed
by
blood‐brain
barrier
(BBTB).
Here,
an
strategy
presented
NPs
glioblastomas
through
glucose
transporters
(GLUT)
overexpressed
endothelial
cells
of
glioblastoma
microvasculature,
GLUT1.
Specifically,
Iron
Oxide
Nanoparticles
(IONPs)
functionalized
with
glucuronic
acid
promote
GLUT‐mediated
transcytosis
drastically
boosted
inducing
mild
hypoglycemia.
This
metabolically‐driven
active
targeting
has
yielded
unprecedented
efficacy
in
glioblastomas.
Moreover,
IONPs,
designed
act
as
magnetic
hyperthermia
(MH)
mediators,
used
conduct
proof‐of‐concept
preclinical
study
MRI‐tracked
MH
therapy
following
intravenous
administration,
resulting
significant
growth
delay.
These
findings
demonstrate
unparalleled
efficiency
lay
ground
developing
alternative
glioblastoma.
Язык: Английский
Immunostimulatory hydrogel with synergistic blockage of glutamine metabolism and chemodynamic therapy for postoperative management of glioblastoma
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 3, 2024
Abstract
Glioblastoma
multiforme
(GBM)
stands
as
one
of
the
most
lethal
malignant
brain
tumors
affecting
central
nervous
system.
Post-surgery,
patients
encounter
daunting
challenges
like
tumor
recurrence,
increased
intracranial
pressure
due
to
cavitation,
and
constraints
linked
with
immediate
postoperative
oral
chemotherapy.
Herein,
we
construct
an
injected
peptide
gel
in
situ
immunostimulatory
functions
harmonize
regulation
glutamine
metabolism
chemodynamic
therapy
tackling
obstacles.
The
methodology
entails
crafting
injectable
scaffolds
short
molecules,
incorporating
glutaminase
inhibitor
CB-839
copper
self-assembled
particles
(Cu-His
NPs)
renowned
for
their
(CDT)
efficacy.
By
fine-tuning
glutamic
acid
production
via
metabolic
pathways,
our
system
not
only
heightens
therapeutic
prowess
CDT
but
also
escalates
intracellular
oxidative
stress.
This
dual
mechanism
culminates
augmented
immunogenic
cell
death
(ICD)
within
glioblastoma
cells
improves
a
conducive
immune
microenvironment.
Anchored
on
tenets
reprogramming,
this
treatment
strategy
showcases
substantial
promise
significantly
curtailing
GBM
prolonging
median
survival
murine
models.
Язык: Английский
Breaking Through Physiological Barriers: Nanorobotic Strategies for Active Drug Delivery
Bioconjugate Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Self-propelled
micro/nanomotors
(MNMs)
represent
a
groundbreaking
advancement
in
precision
drug
delivery,
offering
potential
solutions
to
persistent
challenges
such
as
systemic
toxicity,
limited
bioavailability,
and
nonspecific
distribution.
By
transforming
various
energy
sources
into
mechanical
motion,
MNMs
are
able
autonomously
navigate
through
complex
physiological
environments,
facilitating
targeted
delivery
of
therapeutic
agents
previously
inaccessible
regions.
However,
achieve
efficient
vivo
biomedical
must
demonstrate
their
ability
overcome
crucial
barriers
encompassing
mucosal
surfaces,
blood
flow
dynamics,
vascular
endothelium,
cellular
membrane.
This
review
provides
comprehensive
overview
the
latest
strategies
developed
address
these
obstacles
while
also
analyzing
broader
opportunities
associated
with
clinical
translation.
Our
objective
is
establish
solid
foundation
for
future
research
medical
by
focusing
on
enhancing
efficiency
advancing
medicine,
ultimately
paving
way
practical
theragnostic
applications
wider
adoption.
Язык: Английский