
ACS Omega, Год журнала: 2024, Номер 9(36), С. 38126 - 38141
Опубликована: Авг. 24, 2024
Three different annulation modes of (Z)-4-aryl-4-oxo-2-(pyridin-2-yl)but-2-enenitrile in the reaction with methyl nitroacetate were discovered, allowing selective access to diverse heterocycles such as quinolizin-4-one, isoxazole, and indolizine unique substitution patterns good yields. Ease operation, chemical yields, functional group tolerance our protocol enabled us rapidly construct a number synthetic analogs based on each scaffold under three conditions.
Язык: Английский