Research on Chemical Intermediates, Год журнала: 2024, Номер 50(9), С. 4229 - 4247
Опубликована: Июль 26, 2024
Язык: Английский
Research on Chemical Intermediates, Год журнала: 2024, Номер 50(9), С. 4229 - 4247
Опубликована: Июль 26, 2024
Язык: Английский
The Journal of Organic Chemistry, Год журнала: 2025, Номер 90(4), С. 1663 - 1670
Опубликована: Янв. 21, 2025
1H-Isochromene scaffolds are ubiquitous in natural products and significant bioactive molecules. Although several methods for these molecular syntheses have been developed, reports on the efficient construction of iminated isochromenes still rather limited. Herein, we report a new Cu(II)-catalyzed annulation sulfonylimination cascade α-carbonyl-γ-alkynyl sulfoxonium ylides with sulfamides, enabling direct C-C σ-bond elimination to furnish (Z)-1H-isochromenes 51-97% yields. During reaction process, ylide unit as traceless eliminative group is key successful sulfonylimination, which enables N-H insertion subsequent acetic acid-mediated elimination.
Язык: Английский
Процитировано
1The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 25, 2025
p-CF3BnSeCF2Br was developed as a bromodifluoromethylselenonating reagent, which utilized by combining with mCPBA and Tf2O for the synthesis of 4-(bromodifluoromethylseleno) isocoumarins via selenolation/lactonization 2-alkynylbenzoates. The transformation postulated to proceed multicomponent reagents system-enabled sequence involving oxidation into its selenium sulfoxide, activation generated sulfoxide electrophilic p-CF3BnSeOCF2Br salt, 2-alkynylbenzoates reactive species isocoumarins.
Язык: Английский
Процитировано
0Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
A class of sulfonium ylide-based reagents for electrophilic deuteriodifluoromethylation is reported. Thus, a wide array ubiquitous O-nucleophiles such as sulfonic acid, alcohol, carboxyl and phosphoric acid are deuteriodifluoromethylated, providing straightforward approach to access the OCF2D-functionalizazed scaffolds that otherwise challenging synthesize using conventional methods. This base-free protocol also displays broad functional group compatibility amenable effective late-stage modification bioactive molecules.
Язык: Английский
Процитировано
0Research on Chemical Intermediates, Год журнала: 2024, Номер 50(9), С. 4229 - 4247
Опубликована: Июль 26, 2024
Язык: Английский
Процитировано
2