Facile synthesis of β‐trifluoromethyl thioethers via DBN‐catalyzed hydrothiolation of a‐trifluoromethyl styrenes with thiols

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(20)

Опубликована: Июль 23, 2024

Abstract A very simple and atom‐economical method for the synthesis of vicinal trifluoromethyl thioethers via DBN‐catalyzed hydrothiolation α‐(trifluoromethyl)styrenes with thiols was reported. The reaction proceeded smoothly under mild conditions provided β‐CF 3 ‐thioethers in moderate to good yields an anti‐Markovnikov manner. Furthermore, this features several remarkable advantages, such as use a catalytic amount DBN, broad substrate scope, excellent functional group compatibility, easy scalability.

Язык: Английский

Tunable base-controlled chemoselective synthesis of trifluoromethyl-containing N-substituted benzimidazole-2-thiones and monofluorinated 4H-benzo[4,5]imidazo[2,1-b][1,3]thiazine

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

A base-controlled synthesis of N -β-CF 3 -substituted 2 H -benzo[ d ]imidazole-2-thiones and 2-fluoro-4 -benzo[4,5]imidazo[2,1- b ][1,3]thiazines via hydroamination or defluorinative cyclizations α-CF -styrenes with 2-mercaptobenzimidazole was developed.

Язык: Английский