Synthesis of 1,3,4-thiadiazoles from elemental sulfur via three-component cyclization under metal-free conditions
Chuanquan Chu,
Yu Liu,
Min Mao
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
In
this
work,
we
demonstrate
the
synthesis
of
a
variety
2,5-disubstituted
1,3,4-thiadiazoles
in
28-85%
yields
via
three-component
cyclization
2-methylquinolines,
arylhydrazides,
and
S
powder
under
metal-free
conditions.
This
approach
stands
out
due
to
its
broad
substrate
scope,
excellent
functional
group
tolerance,
additive-free
nature,
base-free
easy
operation,
simple
reaction
system.
work
offers
simple,
concise,
convenient
pathway
for
assembly
1,3,4-thiadiazoles,
which
is
complementary
previous
methods.
Язык: Английский
Developments in the Construction of Benzo[b]thiophenes from 2‐Alkynylthioanisoles by Electrophilic and Radical Cyclization Reactions
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Abstract
Benzo[
b
]thiophene
moieties
are
important
skeletons
which
have
been
widely
found
in
many
natural
products,
pharmaceuticals,
as
well
functionalized
materials.
2‐Alkynylthioanisoles,
a
class
of
bifunctional
compounds
bearing
methylthio
and
alkynyl
groups,
easily
accessible
from
Pd‐catalyzed
Sonogashira
coupling
between
2‐halothioanisoles
terminal
alkynes,
employed
synthons
the
construction
benzo[b]thiophenes
through
an
electrophilic
or
radical
pathway.
This
review
summarizes
related
developments
with
particular
focus
on
reaction
mechanism.
We
hope
it
will
help
future
research
this
area
believe
that
discovery
new
catalytic
systems,
industrial
synthesis
benzo[
]thiophenes
2‐alkynylthioanisoles
be
achieved
soon.
Язык: Английский