In Situ Generation and [3 + 2] Annulation Reactions of Propiolaldehyde─A Metal-Free, Cascade Route to Pyrazole and Bipyrazole Carboxaldehydes in One Pot DOI

Mariswamy K. Sreelekha,

Ali Shamnad, Rasmi P. Bhaskaran

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Propiolaldehyde, the most reactive yet less explored electrophilic acetylene, was generated in situ via a base-free Kornblum oxidation from propargyl tosylate and successfully intercepted with hydrazones affording pyrazole-4-carboxaldehyde one-pot by [3 + 2] annulation reaction. Further, endured unique cascade reaction phenylhydrazine tosylate, yielding synthetically challenging bipyrazole carboxaldehydes. The method is free of any metal catalyst, base, or additives offers convenient protocol to handle volatile propiolaldehyde under ambient conditions.

Язык: Английский

Thiazolidine Derivatives as Promising Prostate Cancer Agents: Design, Synthesis, In Vitro Evaluation, DFT, ADME, POM, Docking, and Toxicity Studies DOI

Hamsa Hussein Al-Hujaj,

Ahmed A. Majed,

Qeaser R. Abdalzahra

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142544 - 142544

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
In Situ Generation and [3 + 2] Annulation Reactions of Propiolaldehyde─A Metal-Free, Cascade Route to Pyrazole and Bipyrazole Carboxaldehydes in One Pot DOI

Mariswamy K. Sreelekha,

Ali Shamnad, Rasmi P. Bhaskaran

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Propiolaldehyde, the most reactive yet less explored electrophilic acetylene, was generated in situ via a base-free Kornblum oxidation from propargyl tosylate and successfully intercepted with hydrazones affording pyrazole-4-carboxaldehyde one-pot by [3 + 2] annulation reaction. Further, endured unique cascade reaction phenylhydrazine tosylate, yielding synthetically challenging bipyrazole carboxaldehydes. The method is free of any metal catalyst, base, or additives offers convenient protocol to handle volatile propiolaldehyde under ambient conditions.

Язык: Английский

Процитировано

0