Zinc‐Catalysed [3+2] Cycloaddition of Enaminone with Tosylhydrazide to Synthesise 1H‐pyrazole via C–N and S–N Bond Cleavage
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Abstract
A
novel
and
practical
zinc‐catalysed
synthesis
of
1
H
‐pyrazole
has
been
developed.
The
one‐pot
protocol
enables
the
cycloaddition
enaminone
tosylhydrazide
via
C−N
S−N
bond
breaking
process,
leading
to
diverse
mono‐substituted
pyrazole
derivatives
in
high
yields.
Moreover,
easily
accessible
materials,
broad
substrate
scope
with
excellent
functional
group
tolerance,
ease
isolation
open‐air
conditions
are
key
features
present
method.
Язык: Английский
Mechanochemical Synthesis of Phosphoryl Amides and Esters from Diphenylphosphoryl Azides Under Mild Conditions
ChemistrySelect,
Год журнала:
2024,
Номер
9(46)
Опубликована: Дек. 1, 2024
Abstract
A
simple,
efficient,
and
one‐step
synthetic
procedure
to
construct
phosphoryl
amides
esters
has
been
developed
applying
mechanochemistry.
ball‐milling
technique
easily
facilitated
the
amination
esterification
of
diphenylphosphoryl
azides
(DPPA)
in
presence
molecular
iodine
sodium
carbonate
via
cleavage
P—N
bond.
The
metal‐free
mechanochemical
protocol
enables
transformations
provide
a
variety
alkyl
under
solvent‐free
conditions
at
room
temperature.
Moreover,
readily
available
inexpensive
starting
materials,
excellent
functional
group
compatibility,
rapid
synthesis,
high
yields
products,
mild
are
notable
features
present
method.
Язык: Английский