I₂/DMSO Mediated [5+1] Oxidative Annulation of Aryl Methyl Ketones with 2‐(2H‐Indazol‐2‐yl)anilines for the Synthesis of Indazoloquinoxalines

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Abstract A metal‐free, iodine‐mediated protocol has been developed to synthesize indazoloquinoxaline derivatives from readily accessible substrates such as 2‐(2 H ‐indazol‐2‐yl)anilines and aryl methyl ketones. This operationally simple, one‐pot reaction proceeds through iodine/DMSO‐mediated C(sp 3 )‐H oxidation of ketones, followed by imine formation annulation furnish the desired products. wide range including drug‐derived substrates, were compatible in present reaction. Further, is scalable, demonstrating its applicability on a larger scale.

Язык: Английский

Visible-light-promoted I2-Catalyzed synthesis of quinoxalines and 2-Benzoylquinazolin-4(3H)-ones from acetophenones

Molecular Catalysis, Год журнала: 2024, Номер 572, С. 114760 - 114760

Опубликована: Дек. 13, 2024

Язык: Английский