Synthesis of Benzoisochromene Derivatives via C–H Activation-Initiated Cascade Formal [4+2] and [2+4] Annulation of Aryl Enaminone with Vinyl-1,3-dioxolan-2-one
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Cascade
annulation
reactions
can
assemble
structurally
intricate
polycyclic
molecules
from
simple
starting
materials
with
enhanced
efficiency
and
minimized
production
of
waste.
Presented
herein
is
a
concise
effective
synthesis
benzoisochromene
derivatives
based
on
C-H
activation-initiated
cascade
formal
[4+2]/[2+4]
aryl
enaminone
vinyl-1,3-dioxolan-2-one.
In
constructing
the
six-membered
carbocycle,
acted
as
C4
synthon
while
vinyl-1,3-dioxolan-2-one
C2
synthon.
O-heterocycle,
other
hand,
former
latter
C3O1
To
our
knowledge,
this
first
simultaneous
construction
both
carbocycle
an
O-heterocycle
via
concurrent
C-H/C-N/C-O
bond
cleavage
C-C/C-C/C-O
formation.
general,
novel
protocol
features
use
readily
obtainable
substrates
broad
scope,
excellent
atom-
step-economy,
intriguing
reaction
pathway,
valuable
products.
Язык: Английский
Rh-Catalyzed and Self-Directed Aromatic C–H Activation of Enaminones to Divergent Alkenylated and Annulated Compounds
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
Язык: Английский
Directed Cascade C–H Functionalization/2-Fold Annulation with Vinylcyclopropanes: Access to Tetrahydrobenzo[g]isochromen-10-ones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Rh-catalyzed
enaminone
directed
cascade
C-H
functionalization/2-fold
annulation
with
vinylcyclopropanes
has
been
accomplished
to
afford
functionalized
tetrahydrobenzo[g]isochromen-10-ones.
The
sequential
C-H/C-C
functionalization,
C-C/C-O
bond
formation,
redox-neutral
conditions,
functional
group
tolerance,
and
late-stage
modification
of
the
natural
products
are
important
practical
features.
Язык: Английский
Photocatalytic Three-Component Assemblies of Enaminones, α-Diazo Esters, and Nitriles for the Synthesis of N,N-Diacylated Glycine Esters
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
A
facile
method
with
simple
starting
materials,
including
enaminones,
α-diazo
esters,
and
nitriles,
has
been
developed
for
the
direct
synthesis
of
N,N-diacyl
glycine
esters
via
visible
light
photocatalysis.
The
reaction
involves
a
novel
carbon-carbon
bond
cleavage
in
leading
to
products
high
tolerance
variability
substructures
among
all
three
components.
Язык: Английский
Synthesis of trans‐2‐(Disubstituted‐amino)alkenyl Polyoxyperfluoroalkyl Ketones from Tertiary Amines and Perfluoroalkyl Ether Carboxylates Featuring “–CF2O–” Units†
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Comprehensive
Summary
A
one‐pot
transformation
of
aliphatic
and
aromatic
tertiary
amines
to
novel
fluorinated
enaminones
has
been
developed,
utilizing
perfluoroalkyl
ether
carboxylates
(PFECA
salts)
featuring
“–CF
2
O–”
units
as
the
fluorine‐containing
reagents.
Carbonyl
fluoride,
acyl
fluorides
anhydrides
by
thermal
decomposition
these
PFECA
salts
were
proposed
act
key
active
species
that
trigger
tandem
oxidation–acylation
process
amines,
through
enamine
intermediates.
Язык: Английский