Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106978 - 106978
Опубликована: Апрель 1, 2025
Язык: Английский
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 296 - 296
Опубликована: Фев. 24, 2025
Melanoma, a highly aggressive form of skin cancer, poses major therapeutic challenge due to its metastatic potential, resistance conventional therapies, and the complexity tumor microenvironment (TME). Materials science nanotechnology advances have led using nanocarriers such as liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles transformative solutions for precision melanoma therapy. This review summarizes findings from Web Science, PubMed, EMBASE, Scopus, Google Scholar highlights role in overcoming treatment barriers. Nanoparticles facilitate passive active targeting through mechanisms enhanced permeability retention (EPR) effect functionalization with tumor-specific ligands, thereby improving accuracy drug delivery reducing systemic toxicity. Stimuli-responsive systems multi-stage further improve overcome challenges poor penetration resistance. Emerging platforms combine diagnostic imaging delivery, paving way personalized medicine. However, there are still issues scalability, biocompatibility, regulatory compliance. comprehensive potential integrating genetics proteomics, scalable, patient-specific therapies. These interdisciplinary innovations promise redefine provide safer, more effective, accessible treatments. Continued research is essential bridge gap between evidence-based scientific clinical applications.
Язык: Английский
Процитировано
1
Physical Sciences Reviews, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Abstract This chapter highlights challenges and advancements in the production of lipid-based nanoparticles (LNPs) their application nucleic acid-based therapies. Recently, mRNA-based vaccines for COVID-19 immunization revealed that use acids is a promising strategy to develop treatments at high therapeutic efficiency reduced side effects. In this context, LNPs emerged as favourable vehicles delivery (like mRNA DNA), due biocompatibility, bioavailability, versatility. The four main components employed produce loaded with are: cationic or ionizable lipids, helper cholesterol, PEGylated lipids. Several conventional techniques have been proposed over years kind nanoparticles. However, they show many drawbacks hinder direct vesicles characterized by nanometric size, encapsulation active pharmaceutical ingredient, prolonged stability. Processes assisted supercritical fluids (in particular, CO 2 ) can represent sustainable interesting alternative without using post-processing steps solvent removal size reduction are time-consuming procedures, lead large loss acids, negatively influence general productivity process.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 523 - 523
Опубликована: Апрель 16, 2025
Background/Objectives: Indomethacin (IND) is a widely used non-steroidal anti-inflammatory drug (NSAID) effective in managing pain and inflammation. However, its therapeutic use often limited by gastrointestinal irritation low bioavailability. This study aimed to evaluate the biocompatibility, release kinetics, analgesic potential of IND-loaded chitosan (CHIT)-stabilized lipid vesicles (IND-ves) comparison free IND, focusing on their vivo effects impact somatic nociceptive reactivity mice. Methods: IND-ves were prepared using molecular droplet self-assembly technique, followed CHIT coating enhance stability control release. Mice administered either IND or IND-ves, various physiological parameters, including liver kidney function, oxidative stress markers, immune cell activity, histopathological changes key organs, assessed. Plasma kinetics evaluated tail-flick test. Results: Both demonstrated good with no significant hematological, biochemical, immunological profiles. exhibited sustained profile, initiating at 30 min peaking 3 h, while displayed rapid gastric mucosal damage. did not induce inflammation maintained organ integrity, particularly protecting against injury. Additionally, prolonged profile contributed extended Conclusions: CHIT-stabilized offer promising delivery system for enhancing release, prolonging efficacy, minimizing irritation. These findings suggest that could serve as safer more alternative NSAID therapy.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(8), С. 1845 - 1845
Опубликована: Апрель 20, 2025
The aim of this study was to investigate the encapsulation natural food dyes incorporated into liposomes in terms particle size, rheological and colour properties, zeta potential, efficiency. contained dye substances anthocyanins from freeze-dried raspberry powder (R), copper complexes chlorophyllins (C), or commercial-grade β-carotene (B). phospholipid envelope composed sunflower lecithin carboxymethylcellulose sodium salt as a surface stabilizer treated by high-pressure homogenization. median diameter R C systems fluctuated around 200 nm, while B showed broader range 165–405 nm. results demonstrated specific flow behaviour pattern dependent on rotational shear applied, indicating flow-induced structural change dispersions. Samples were characterized translucent profile with relatively high lightness, accompanied hue angle (h*) typical encapsulated. potential approx. −30 mV, showing electrokinetically stabilized efficiency (EE) varied significantly, highest EE observed for anthocyanins, ranging 36.17 84.61%. chlorophyll least effective, determined between 1.82 16.03%. Based suitability index, optimal liposomal formulations evaluated means Central Composite Design (CCD).
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106978 - 106978
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0