Polymer, Год журнала: 2024, Номер unknown, С. 127758 - 127758
Опубликована: Окт. 1, 2024
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Antimicrobial peptides (AMPs) and synthetic topologically defined peptide mimics have been developed as alternatives to traditional small-molecule antibiotics. AMP mimetics arising from linear polymers used widely in preclinical studies shown promise but limited stability. Oligomers possessing cyclic topology proposed increased stability remain understudied due challenges concerns over cytotoxicity. Herein, we present an efficient approach prepare cationic, oligo(disulfide)s (CCOs) lipoic acid derivatives. The CCOs are obtained a one-pot cascade reaction of ring-opening polymerization preceding situ cyclo-depolymerization. effective against broad spectrum bacteria, exhibiting 5.43-log reduction 5 min Escherichia coli. They did not induce antimicrobial resistance during 24 successive passages vitro. cytotoxicity is reduced by exploiting glutathione-triggered degradation. Further, fine-tuning the cationic-to-hydrophilic ratio has yielded improved serum high selective index (HC50/MIC > 1280) methicillin-resistant Staphylococcus aureus. In infected wound rodent model, substantial antibacterial potency S. aureus, underscoring their therapeutic potential new class agents.
Язык: Английский
Процитировано
1
Polymer Engineering and Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Abstract Poly(butylene succinate) (PBS) is a biodegradable polymer material. The main disadvantages of PBS are high crystallinity, poor toughness, and slow degradation rate. To solve these problems, was modified by block copolymerization. In this paper, hydroxy‐terminated poly (butylene (HO‐PBS‐OH) poly(triethylene glycol (HO‐PTEG‐OH) were synthesized, then HDI (1,6‐diisocyanated'hexamethylene) used as chain extender. A series poly(butylene succinate‐b‐triethylene (PBS‐b‐PTEG) prepared. structure properties the copolymer characterized 1H‐NMR, DSC, XRD, electronic universal testing machine, test. results showed that copolymers miscible in amorphous region. show region, there only one glass transition temperature melting point. crystallinity decreased with increase PTEG segment. addition segment enhanced toughened increased elongation at break PBS‐b‐PTEG 20% sample to 3.2 times PBS. test could improve performance Highlights has good hydrophilicity can be soft copolymers. higher better toughness compared ( T m ) PBS‐b‐PTFE did not significantly decrease. destroyed increasing rate
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(42), С. 56469 - 56480
Опубликована: Окт. 9, 2024
The stimulus-responsive polymeric materials have attracted great research interest, especially those remotely manipulated with potential applications in actuators and soft robotics. Here we report a photoresponsive main-chain actuator based on azobenzene poly(ether ester) multiblock copolymer (mBCP) thermoplastic elastomers, (PTAD-b-PTMO-b-PTAD)n, which were synthesized by cascade polycondensation-coupling ring-opening polymerization method using poly(tetramethylene oxide) (PTMO) azobenzene-containing cyclic oligoesters (COTADs) as monomers. thermal, mechanical, microphase separation behaviors of mBCPs could be flexibly tuned altering the ratios soft-to-hard segments block number (n). oriented mBCP fibers prepared melt spinning, showing reversible properties remarkably high strength (∼1000 MPa) elongation at break comparable to spider silks. Fast photoinduced bending contraction successfully achieved these work power densities energy conversion efficiency, enabling it lift up about 250 times its own weight. Moreover, can take out inside tube UV-light control. These applied light-driven or telecontrolled robot arms.
Язык: Английский
Процитировано
3
Polymer, Год журнала: 2024, Номер unknown, С. 127758 - 127758
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
1