Catalyzing PET‐RAFT Polymerizations Using Inherently Photoactive Zinc Myoglobin DOI Creative Commons
Ian C. Anderson, David Gómez, Meijing Zhang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Окт. 29, 2024

Abstract Protein photocatalysts provide a modular platform to access new reaction pathways and affect product outcomes, but their use in polymer synthesis is limited because co‐catalysts and/or co‐reductants are required complete catalytic cycles. Herein, we report using zinc myoglobin (ZnMb), an inherently photoactive protein, mediate photoinduced electron/energy transfer (PET) reversible addition‐fragmentation chain (RAFT) polymerizations. Using ZnMb as the sole reagent for catalysis, photomediated polymerizations of N , ‐dimethylacrylamide PBS were achieved with predictable molecular weights, dispersity values approaching 1.1, high chain‐end fidelity. We found that initial apparent rate constants polymerization increased from 4.6×10–5 s −1 mesoporpyhrin IX (ZnMIX) 6.5×10–5 when ZnMIX was incorporated into yield ZnMb, indicating protein binding site enhanced activity. Chain extension reactions comparing ZnMb‐mediated RAFT thermally‐initiated showed minimal differences block copolymer weights dispersities. This work enables studies elucidate how modifications (e.g., secondary structure folding, site‐directed mutagenesis, directed evolution) can be used modulate outcomes selective monomer additions towards sequence control, tacticity molar mass distributions).

Язык: Английский

Polymeric brushes for enhanced biological applications: advancements in sustainable approach DOI

Aayush Prakash,

Sathvik Belagodu Sridhar,

Adil Farooq Wali

и другие.

International Journal of Polymeric Materials, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0
Enzymatic polymerization: Recent advances toward sustainable polymer synthesis DOI
Bo Xia, Honghao Chen, Juntao Wang

и другие.

Biotechnology Advances, Год журнала: 2025, Номер unknown, С. 108566 - 108566

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Catalyzing PET‐RAFT Polymerizations Using Inherently Photoactive Zinc Myoglobin DOI Creative Commons
Ian C. Anderson, David Gómez, Meijing Zhang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

Abstract Protein photocatalysts provide a modular platform to access new reaction pathways and affect product outcomes, but their use in polymer synthesis is limited because co‐catalysts and/or co‐reductants are required complete catalytic cycles. Herein, we report using zinc myoglobin (ZnMb), an inherently photoactive protein, mediate photoinduced electron/energy transfer (PET) reversible addition‐fragmentation chain (RAFT) polymerizations. Using ZnMb as the sole reagent for catalysis, photomediated polymerizations of N , ‐dimethylacrylamide PBS were achieved with predictable molecular weights, dispersity values approaching 1.1, high chain‐end fidelity. We found that initial apparent rate constants polymerization increased from 4.6×10–5 s −1 mesoporpyhrin IX (ZnMIX) 6.5×10–5 when ZnMIX was incorporated into yield ZnMb, indicating protein binding site enhanced activity. Chain extension reactions comparing ZnMb‐mediated RAFT thermally‐initiated showed minimal differences block copolymer weights dispersities. This work enables studies elucidate how modifications (e.g., secondary structure folding, site‐directed mutagenesis, directed evolution) can be used modulate outcomes selective monomer additions towards sequence control, tacticity molar mass distributions).

Язык: Английский

Процитировано

0
Catalyzing PET‐RAFT Polymerizations Using Inherently Photoactive Zinc Myoglobin DOI Creative Commons
Ian C. Anderson, David Gómez, Meijing Zhang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Окт. 29, 2024

Abstract Protein photocatalysts provide a modular platform to access new reaction pathways and affect product outcomes, but their use in polymer synthesis is limited because co‐catalysts and/or co‐reductants are required complete catalytic cycles. Herein, we report using zinc myoglobin (ZnMb), an inherently photoactive protein, mediate photoinduced electron/energy transfer (PET) reversible addition‐fragmentation chain (RAFT) polymerizations. Using ZnMb as the sole reagent for catalysis, photomediated polymerizations of N , ‐dimethylacrylamide PBS were achieved with predictable molecular weights, dispersity values approaching 1.1, high chain‐end fidelity. We found that initial apparent rate constants polymerization increased from 4.6×10–5 s −1 mesoporpyhrin IX (ZnMIX) 6.5×10–5 when ZnMIX was incorporated into yield ZnMb, indicating protein binding site enhanced activity. Chain extension reactions comparing ZnMb‐mediated RAFT thermally‐initiated showed minimal differences block copolymer weights dispersities. This work enables studies elucidate how modifications (e.g., secondary structure folding, site‐directed mutagenesis, directed evolution) can be used modulate outcomes selective monomer additions towards sequence control, tacticity molar mass distributions).

Язык: Английский

Процитировано

0