Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach DOI
M. Akhtar, Hammad Majeed, Tehreema Iftikhar

и другие.

Toxicology Research, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 31, 2024

Abstract Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at price of environment. Due to rise in illnesses, Industry 6.0 calls for a renewed dedication sustainability with latest technologies. Focused research creative solutions are needed achieve UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs perfect drug administration because their high surface areas, adjustable pore sizes, remarkable drug-loading capacities. They created by combining advanced artificial intelligence, intelligent manufacturing, quantum computing. Researchers can create functional groups or ligands that bind selectively target cells tissues, minimizing off-target effects, thanks distinct benefits families like MIL, HKUST, UiO, ZIF etc. offer targeted delivery. Combining other nanomaterials results multipurpose systems handle challenging biomedical issues. Despite its promise, there still issues MOFs’ possible toxicity long-term stability physiological settings. To advance medicinal applications, these problems must be resolved. increase usefulness medicine critically analysing limitations putting up alternatives. The creation technologies (additive manufacturing etc.) delivery prime example how scientific stewardship may coexist provide advantageous both people

Язык: Английский

Progress on layered double hydroxides as green materials in sustainable agricultural production DOI
Tongtong Zhang, Zhenghong Xu,

Zhihua Xu

и другие.

Environmental Research, Год журнала: 2025, Номер unknown, С. 121031 - 121031

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Advances in metal-organic framework-based drug delivery systems DOI

M T Khulood,

U. S. Jijith,

Punnoth Poonkuzhi Naseef

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125380 - 125380

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Hybrid Systems of Gels and Nanoparticles for Cancer Therapy: Advances in Multifunctional Therapeutic Platforms DOI Creative Commons
Kibeom Kim

Gels, Год журнала: 2025, Номер 11(3), С. 170 - 170

Опубликована: Фев. 26, 2025

Cancer is a global health concern. Various therapeutic approaches, including chemotherapy, photodynamic therapy, and immunotherapy, have been developed for cancer treatment. Silica nanoparticles, quantum dots, metal–organic framework (MOF)-based nanomedicines gained interest in therapy because of their selective accumulation tumors via the enhanced permeability retention (EPR) effect. However, bare nanoparticles face challenges poor biocompatibility, low stability, limited drug-loading capacity, rapid clearance by reticuloendothelial system (RES). Gels with unique three-dimensional network structures formed through various interactions such as covalent hydrogen bonds are emerging promising materials addressing these challenges. Gel hybridization enhances facilitates controlled drug release, confers cancer-targeting abilities to nanoparticles. This review discusses gel–nanoparticle hybrid systems treatment past five years analyzes roles gels systems.

Язык: Английский

Процитировано

0
Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin DOI Creative Commons

Syeda Fiza Fatima,

Rana Sabouni, Ghaleb A. Husseini

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(13), С. 1081 - 1081

Опубликована: Июнь 24, 2024

Metal-organic frameworks (MOFs) are excellent candidates for a range of applications because their numerous advantages, such as high surface area, porosity, and thermal chemical stability. In this study, microwave (MW) irradiation is used novel stimulus in vitro controlled release Doxorubicin (DOX) from two MOFs, namely Fe-BTC MIL-53(Al), to enhance drug delivery cancer therapy. DOX was encapsulated into MIL-53(Al) with drug-loading efficiencies up 67% 40% MIL-53(Al). Several characterization tests, including XRD, FTIR, TGA, BET, FE-SEM, EDX, confirmed both MOF samples’ -release mechanisms. exhibited substantial improvement drug-release efficiency (54%) when exposed at pH 7.4 50 min, whereas 11% achieved without the external modality. A similar result observed 5.3; however, cases, were substantially higher exposure (40%) than (6%). contrast, greater sensitivity pH, displaying rate (66%) after 38 min 5.3 compared 55% subjected irradiation. These results highlight potential MOFs highly heat-responsive stimuli. The MTT assay demonstrated cell viability across different concentrations days incubation. This suggests that hold promise tumor targeting. Additionally, fact cells maintained durations confirms latter safe modality triggering MOFs.

Язык: Английский

Процитировано

3
The exploration of Nanozymes for biosensing of pathological states tailored to clinical theranostics DOI

Abdul Sayeed Khan,

Sudhir Kumar Sahu, Santosh Kumar Dash

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

The nanozymes (NZs) are the artificial catalyst deployed for biosensing with their uniqueness (high robustness, surface tenability, inexpensive, and stability) obtaining a better response/miniaturization of varied sensors than traditional ancestors. Nowadays, nanomaterials broadened scale such as metal-organic frameworks (MOFs), metals/metal oxides widely engaged in generating NZ-based biosensors (BS). Diverse strategies like fluorescent, colorimetric, surface-enhanced Raman scattering (SERS), electrochemical sensing principles were implemented signal transduction NZs. Despite broad advantages, numerous encounters (like specificity, feasibility, stability, issues scale-up) affecting potentialities NZs-based BS, thus need prior attention promising exploration revolutionary outcome advanced theranostics. This review includes different types NZs, progress NZs tailored bio-sensing techniques detecting abundant bio analytes theranostic purposes. Further, discussion highlighted some recent challenges along progressive way possibly overcoming followed by commercial outbreaks.

Язык: Английский

Процитировано

2
Incorporation anthracene and Cu to NH2-Zr-UiO-67 metal-organic framework: Introducing the simultaneous selectivity and efficiency in photocatalytic CO2 reduction to ethanol DOI
Mohamed J. Saadh, Mohammed Ahmed Mustafa, Farag M. A. Altalbawy

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1318, С. 139329 - 139329

Опубликована: Июль 24, 2024

Язык: Английский

Процитировано

2
Hyaluronic acid-covered ferric ion-rich nanobullets with high zoledronic acid payload for breast tumor-targeted chemo/chemodynamic therapy DOI

Nien-Tzu Yeh,

T. Lin,

I-Ju Liu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135271 - 135271

Опубликована: Сен. 2, 2024

Язык: Английский

Процитировано

2
MOF-based spectrophotometric sensors for cholesterol detection: current trends and challenges DOI Creative Commons

Heba Abed,

Rana Sabouni, Mehdi Ghommem

и другие.

RSC Advances, Год журнала: 2024, Номер 14(53), С. 39472 - 39497

Опубликована: Янв. 1, 2024

Cholesterol detection using MOF-based spectrophotometric sensors has great potential, especially in point-of-care testing applications.

Язык: Английский

Процитировано

0
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach DOI
M. Akhtar, Hammad Majeed, Tehreema Iftikhar

и другие.

Toxicology Research, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 31, 2024

Abstract Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at price of environment. Due to rise in illnesses, Industry 6.0 calls for a renewed dedication sustainability with latest technologies. Focused research creative solutions are needed achieve UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs perfect drug administration because their high surface areas, adjustable pore sizes, remarkable drug-loading capacities. They created by combining advanced artificial intelligence, intelligent manufacturing, quantum computing. Researchers can create functional groups or ligands that bind selectively target cells tissues, minimizing off-target effects, thanks distinct benefits families like MIL, HKUST, UiO, ZIF etc. offer targeted delivery. Combining other nanomaterials results multipurpose systems handle challenging biomedical issues. Despite its promise, there still issues MOFs’ possible toxicity long-term stability physiological settings. To advance medicinal applications, these problems must be resolved. increase usefulness medicine critically analysing limitations putting up alternatives. The creation technologies (additive manufacturing etc.) delivery prime example how scientific stewardship may coexist provide advantageous both people

Язык: Английский

Процитировано

0