Advances in metal-organic framework-based drug delivery systems
M T Khulood,
U. S. Jijith,
Punnoth Poonkuzhi Naseef
и другие.
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125380 - 125380
Опубликована: Фев. 1, 2025
Язык: Английский
Hyaluronic acid-covered ferric ion-rich nanobullets with high zoledronic acid payload for breast tumor-targeted chemo/chemodynamic therapy
Nien-Tzu Yeh,
T. Lin,
I-Ju Liu
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
279, С. 135271 - 135271
Опубликована: Сен. 2, 2024
Язык: Английский
Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin
Nanomaterials,
Год журнала:
2024,
Номер
14(13), С. 1081 - 1081
Опубликована: Июнь 24, 2024
Metal-organic
frameworks
(MOFs)
are
excellent
candidates
for
a
range
of
applications
because
their
numerous
advantages,
such
as
high
surface
area,
porosity,
and
thermal
chemical
stability.
In
this
study,
microwave
(MW)
irradiation
is
used
novel
stimulus
in
vitro
controlled
release
Doxorubicin
(DOX)
from
two
MOFs,
namely
Fe-BTC
MIL-53(Al),
to
enhance
drug
delivery
cancer
therapy.
DOX
was
encapsulated
into
MIL-53(Al)
with
drug-loading
efficiencies
up
67%
40%
MIL-53(Al).
Several
characterization
tests,
including
XRD,
FTIR,
TGA,
BET,
FE-SEM,
EDX,
confirmed
both
MOF
samples’
-release
mechanisms.
exhibited
substantial
improvement
drug-release
efficiency
(54%)
when
exposed
at
pH
7.4
50
min,
whereas
11%
achieved
without
the
external
modality.
A
similar
result
observed
5.3;
however,
cases,
were
substantially
higher
exposure
(40%)
than
(6%).
contrast,
greater
sensitivity
pH,
displaying
rate
(66%)
after
38
min
5.3
compared
55%
subjected
irradiation.
These
results
highlight
potential
MOFs
highly
heat-responsive
stimuli.
The
MTT
assay
demonstrated
cell
viability
across
different
concentrations
days
incubation.
This
suggests
that
hold
promise
tumor
targeting.
Additionally,
fact
cells
maintained
durations
confirms
latter
safe
modality
triggering
MOFs.
Язык: Английский
Progress on layered double hydroxides as green materials in sustainable agricultural production
Environmental Research,
Год журнала:
2025,
Номер
unknown, С. 121031 - 121031
Опубликована: Фев. 1, 2025
Язык: Английский
Hybrid Systems of Gels and Nanoparticles for Cancer Therapy: Advances in Multifunctional Therapeutic Platforms
Gels,
Год журнала:
2025,
Номер
11(3), С. 170 - 170
Опубликована: Фев. 26, 2025
Cancer
is
a
global
health
concern.
Various
therapeutic
approaches,
including
chemotherapy,
photodynamic
therapy,
and
immunotherapy,
have
been
developed
for
cancer
treatment.
Silica
nanoparticles,
quantum
dots,
metal–organic
framework
(MOF)-based
nanomedicines
gained
interest
in
therapy
because
of
their
selective
accumulation
tumors
via
the
enhanced
permeability
retention
(EPR)
effect.
However,
bare
nanoparticles
face
challenges
poor
biocompatibility,
low
stability,
limited
drug-loading
capacity,
rapid
clearance
by
reticuloendothelial
system
(RES).
Gels
with
unique
three-dimensional
network
structures
formed
through
various
interactions
such
as
covalent
hydrogen
bonds
are
emerging
promising
materials
addressing
these
challenges.
Gel
hybridization
enhances
facilitates
controlled
drug
release,
confers
cancer-targeting
abilities
to
nanoparticles.
This
review
discusses
gel–nanoparticle
hybrid
systems
treatment
past
five
years
analyzes
roles
gels
systems.
Язык: Английский
Advancing the potential of nanoparticles for cancer detection and precision therapeutics
Medical Oncology,
Год журнала:
2025,
Номер
42(7)
Опубликована: Июнь 4, 2025
Язык: Английский
The exploration of Nanozymes for biosensing of pathological states tailored to clinical theranostics
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 23, 2024
The
nanozymes
(NZs)
are
the
artificial
catalyst
deployed
for
biosensing
with
their
uniqueness
(high
robustness,
surface
tenability,
inexpensive,
and
stability)
obtaining
a
better
response/miniaturization
of
varied
sensors
than
traditional
ancestors.
Nowadays,
nanomaterials
broadened
scale
such
as
metal-organic
frameworks
(MOFs),
metals/metal
oxides
widely
engaged
in
generating
NZ-based
biosensors
(BS).
Diverse
strategies
like
fluorescent,
colorimetric,
surface-enhanced
Raman
scattering
(SERS),
electrochemical
sensing
principles
were
implemented
signal
transduction
NZs.
Despite
broad
advantages,
numerous
encounters
(like
specificity,
feasibility,
stability,
issues
scale-up)
affecting
potentialities
NZs-based
BS,
thus
need
prior
attention
promising
exploration
revolutionary
outcome
advanced
theranostics.
This
review
includes
different
types
NZs,
progress
NZs
tailored
bio-sensing
techniques
detecting
abundant
bio
analytes
theranostic
purposes.
Further,
discussion
highlighted
some
recent
challenges
along
progressive
way
possibly
overcoming
followed
by
commercial
outbreaks.
Язык: Английский
Incorporation anthracene and Cu to NH2-Zr-UiO-67 metal-organic framework: Introducing the simultaneous selectivity and efficiency in photocatalytic CO2 reduction to ethanol
Journal of Molecular Structure,
Год журнала:
2024,
Номер
1318, С. 139329 - 139329
Опубликована: Июль 24, 2024
Язык: Английский
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach
Toxicology Research,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 31, 2024
Abstract
Since
the
Industrial
Revolution,
ecological
damage,
ecosystem
disruption,
and
climate
change
acceleration
have
frequently
resulted
from
human
advancement
at
price
of
environment.
Due
to
rise
in
illnesses,
Industry
6.0
calls
for
a
renewed
dedication
sustainability
with
latest
technologies.
Focused
research
creative
solutions
are
needed
achieve
UN
Sustainable
Development
Goals
(SDGs),
especially
3,
9,
13,
14,
15,
17.
A
promising
sustainable
technology
enhancing
healthcare
while
reducing
environmental
effect
is
Metal
Organic
Frameworks
(MOFs).
MOFs
perfect
drug
administration
because
their
high
surface
areas,
adjustable
pore
sizes,
remarkable
drug-loading
capacities.
They
created
by
combining
advanced
artificial
intelligence,
intelligent
manufacturing,
quantum
computing.
Researchers
can
create
functional
groups
or
ligands
that
bind
selectively
target
cells
tissues,
minimizing
off-target
effects,
thanks
distinct
benefits
families
like
MIL,
HKUST,
UiO,
ZIF
etc.
offer
targeted
delivery.
Combining
other
nanomaterials
results
multipurpose
systems
handle
challenging
biomedical
issues.
Despite
its
promise,
there
still
issues
MOFs’
possible
toxicity
long-term
stability
physiological
settings.
To
advance
medicinal
applications,
these
problems
must
be
resolved.
increase
usefulness
medicine
critically
analysing
limitations
putting
up
alternatives.
The
creation
technologies
(additive
manufacturing
etc.)
delivery
prime
example
how
scientific
stewardship
may
coexist
provide
advantageous
both
people
Язык: Английский
MOF-based spectrophotometric sensors for cholesterol detection: current trends and challenges
RSC Advances,
Год журнала:
2024,
Номер
14(53), С. 39472 - 39497
Опубликована: Янв. 1, 2024
Cholesterol
detection
using
MOF-based
spectrophotometric
sensors
has
great
potential,
especially
in
point-of-care
testing
applications.
Язык: Английский