Photocatalytic Hydrodichloromethylation of Unactivated Alkenes with Chloroform DOI
Dawei Gong,

Caiyu Gao,

Yanlin Zhang

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

A visible-light-induced method for the hydrodichloromethylation of unactivated alkenes using chloroform (CHCl3) was developed, employing pyridine·BH3 as halogen atom transfer (XAT) reagent. The strategy showed a broad functional group tolerance, and 29 examples alkenes, including complex natural products or drug derivatives, have been established with good yields. Mechanistic studies indicated that CHCl3 serves both source dichloromethyl radical hydrogen (HAT) reagent, borane short-chain reaction process involved in this system. This represents novel approach without an additional HAT

Язык: Английский

A photocatalytic method for the generation of the 1,1,1,3,3,3-hexafluoroisopropyl radical DOI

Sergey S. Lunkov,

Vladislav S. Kostromitin,

Artem A. Zemtsov

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(17), С. 4762 - 4768

Опубликована: Янв. 1, 2024

A method for the generation of hexafluoroisopropyl radical by photoredox cleavage C,O bond is described. The key reagent obtained from hexafluoroisopropanol.

Язык: Английский

Процитировано

1

Sodium Hypophosphite as a Halogen Atom Transfer (XAT) Agent under Photocatalytic Conditions DOI

Ekaterina V. Malakhova,

Vladislav S. Kostromitin,

Demian Y. Cheboksarov

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(17), С. 12812 - 12821

Опубликована: Авг. 9, 2024

The ability of sodium hypophosphite to generate the phosphorus-centered radical, which can activate carbon–halogen bond via halogen atom transfer (XAT) is described. hydroalkylation nonactivated alkenes with methyl bromoacetate was performed using as reducing agent under photocatalytic conditions. key phosphorus centered radical formed from anion by hydrogen abstraction.

Язык: Английский

Процитировано

1

Photocatalytic Hydrodichloromethylation of Unactivated Alkenes with Chloroform DOI
Dawei Gong,

Caiyu Gao,

Yanlin Zhang

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

A visible-light-induced method for the hydrodichloromethylation of unactivated alkenes using chloroform (CHCl3) was developed, employing pyridine·BH3 as halogen atom transfer (XAT) reagent. The strategy showed a broad functional group tolerance, and 29 examples alkenes, including complex natural products or drug derivatives, have been established with good yields. Mechanistic studies indicated that CHCl3 serves both source dichloromethyl radical hydrogen (HAT) reagent, borane short-chain reaction process involved in this system. This represents novel approach without an additional HAT

Язык: Английский

Процитировано

0