The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(22), С. 16531 - 16541

Опубликована: Ноя. 4, 2024

This report discloses a transition-metal-free [4 + 2] spirocyclization of isatin-derived β-silylcarbinols and 2-aminobenzenethiols, providing facile approach to 1,4-benzothiazide spiroindolinones in decent yields. Control experiments indicate that 3-methylene oxindoles disulfides are key intermediates this tandem reaction. Moreover, the resulting products can be facilely converted into pharmaceutically significant sulfone sulfoxide scaffolds, which further demonstrates potential utility protocol.

Язык: Английский