Dearomative 1,4-Difunctionalization of Non-Activated Arenes Enabled by Boryl Radical-Mediated Halogen-Atom Transfer
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 1294 - 1304
Опубликована: Янв. 7, 2025
Given
the
widespread
presence
of
spirocyclic
scaffolds
in
natural
products
and
pharmacologically
relevant
synthetic
compounds,
development
efficient
methodologies
for
their
construction
holds
great
importance
medicinal
chemistry
pharmaceutical
research.
In
this
study,
a
general
photochemical
dearomative
spirocyclization
nonactivated
arenes
has
been
established.
The
key
to
method
lies
ability
amine-borane
radicals
activate
aryl
bromides
iodides
via
halogen-atom
transfer,
thereby
allowing
conversion
halides
into
corresponding
subsequent
chemodivergent
transformations.
remarkable
compatibility
versatility
1,4-difunctionalization
is
showed
by
rapid
assembly
structurally
diverse
1,4-cyclohexadiene-based
spirocycles
incorporating
oxindole,
indoline,
or
dihydrobenzofuran
subunits.
Moreover,
potential
utility
protocol
exemplified
formal
total
synthesis
vasopressin
V2
receptor
antagonist
Satavaptan.
Язык: Английский
Electrochemically Enabled Synthesis of Multi-substituted Pyrazoles via a Radical Cyclization Cascade
Green Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
have
developed
a
mild
and
efficient
electrochemical
reduction
approach
employing
aryl
diazonium
salts
as
dual
synthons
to
synthesize
valuable
multi-substituted
pyrazoles
for
the
first
time.
Язык: Английский
The Electrosynthesis of Highly Encumbered Biaryls from Aryl o-Iodobenzyl Ethers by a Radical to Polar Crossover Sequence.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Highly
encumbered
2,2',6-tri-
and
2,2',6,6'-tetra-substituted
biaryls
are
readily
prepared
from
aryl
ortho-iodobenzyl
ethers
through
mediated
cathodic
reduction
under
flow.
The
reaction
proceeds
via
the
stepwise
transfer
of
two
electrons:
first
to
induce
loss
iodide
a
radical
cyclisation,
second
polar
fragmentation.
Язык: Английский
Electrosynthesis of 1,4-diene derivatives bearing cyclopentene skeleton
Yaqi Qiao,
Xiaoqing Fan,
Chengcheng Yuan
и другие.
iScience,
Год журнала:
2025,
Номер
28(3), С. 111976 - 111976
Опубликована: Фев. 10, 2025
1,n-Dual
Π
systems
including
1,4-diene
derivatives
have
been
widely
used
as
the
elegant
radical
receptors
to
promote
cascade
additions
give
highly
functionalized
polycyclic
scaffolds.
However,
tedious
and
complicated
preparation
of
former
deters
broad
utilization
compromises
practical
value.
Herein,
a
straightforward
was
developed
from
easily
accessible
alkynes
γ,δ-unsaturated
carboxylic
acids
via
electrochemical
oxidation
cyclization
Hofmann
elimination.
This
transformation
features
with
good
excellent
yields,
functional
group
compatibility,
selectivity
without
any
Zaitsev
elimination
product
detected.
Язык: Английский
Harnessing visible light for alkenylation reactions: A promising strategy in organic synthesis
M. Manod,
Archana Vijayakumar,
TS Abhinav
и другие.
Molecular Catalysis,
Год журнала:
2025,
Номер
579, С. 115028 - 115028
Опубликована: Март 22, 2025
Язык: Английский
Alkylthiolation of Aryl Halides under Electrochemical Conditions
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
An
electrochemical
protocol
for
the
alkylthiolation
of
aryl
halides
was
developed.
By
using
dialkyl
disulfides
as
alkylthio
sources,
Mg
plate
sacrificial
anode
and
graphite
felt
(GF)
cathode,
a
series
sulfides
were
obtained
in
moderate
to
good
yields.
The
approach
also
suitable
synthesis
selenides.
This
method
has
features
such
simple
reaction
conditions
functional
group
compatibility,
which
makes
it
have
application
prospect
organic
drug
synthesis.
Язык: Английский