Advances in Pyridine C – H Functionalizations: Beyond C2 Selectivity

Chemistry - A European Journal, Год журнала: 2024, Номер 31(2)

Опубликована: Ноя. 28, 2024

The pyridine core is a crucial component in numerous FDA-approved drugs and Environmental Protection Agency (EPA) regulated agrochemicals. It also plays significant role ligands for transition metals, alkaloids, catalysts, various organic materials with diverse properties, making it one of the most important structural frameworks. However, despite its significance, direct selective functionalization still relatively underdeveloped due to electron-deficient nature strong coordinating ability nitrogen. Among variety synthetic transformation, C-H bond straightforward atom economical approach it's advantageous late-stage containing drugs. In recent years, innovative strategies regioselective pyridines azines have emerged, offering benefits such as high regioselectivity, mild conditions, enabling transformations that were challenging traditional methods. This review emphasizes latest advancements meta para-C-H through approaches, including phosphonium salts, photocatalytic methods, temporary de-aromatization, Minisci-type reactions, metal-catalyzed activation techniques. We discuss advantages limitations these current methods aim inspire further progress this field.

Язык: Английский

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Sequential Conversion of Vinyl Triflates to 1,2-Disilanes via Technical Control of Magnesium and Calcium Reducibility Differences

Organic Letters, Год журнала: 2025, Номер 27(4), С. 948 - 953

Опубликована: Янв. 17, 2025

Reductive direct substitution of α-arylvinyl triflates on the sp2 carbon atom by magnesium in presence chlorosilane proceeded to give corresponding α-silylstyrenes, which could not be reduced further, and reaction completely stopped because reduction potential α-silylstyrenes lies out reducible field magnesium. The subsequent calcium brought about second introduction another silyl group vicinal lead a selective simple route variety 1,2-disilanes from vinyl cooperative works with different potentiality.

Язык: Английский

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Electroreductively driven C–H functionalization of arenes

Chem Catalysis, Год журнала: 2025, Номер unknown, С. 101359 - 101359

Опубликована: Апрель 1, 2025

Язык: Английский

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Electrochemical C–H silylation of azauracils with hydrosilanes

Molecular Catalysis, Год журнала: 2025, Номер 583, С. 115218 - 115218

Опубликована: Май 24, 2025

Язык: Английский

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