Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 789 - 789
Опубликована: Июль 3, 2024
Alginate
is
a
natural
polymer
with
good
biocompatible
properties
and
potential
polymeric
material
for
the
sustainable
development
replacement
of
petroleum
derivatives.
However,
non-spinnability
pure
alginate
solutions
has
hindered
expansion
applications.
With
continuous
electrospinning
technology,
synthetic
polymers,
such
as
PEO
PVA,
are
used
co-spinning
agents
to
increase
spinnability
alginate.
Moreover,
coaxial,
parallel
Janus,
tertiary
other
diverse
novel
electrospun
fiber
structures
prepared
by
multi-fluid
have
found
new
breakthrough
problem
poor
spinning
polymers.
Meanwhile,
effectively
achieve
multiple
release
modes
drugs.
The
powerful
combination
electrostatic
widely
in
many
biomedical
fields,
tissue
engineering,
regenerative
bioscaffolds,
drug
delivery,
research
fever
continues
climb.
This
particularly
true
controlled
delivery
aspect
review
provides
brief
overview
alginate,
introduces
advances
spinning,
highlights
progress
alginate-based
nanofibers
achieving
various
modes,
pulsed
release,
sustained
biphasic
responsive
targeted
release.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9524 - 9524
Опубликована: Сен. 1, 2024
Core–shell
nanostructures
are
powerful
platforms
for
the
development
of
novel
nanoscale
drug
delivery
systems
with
sustained
release
profiles.
Coaxial
electrospinning
is
facile
and
convenient
creating
medicated
core–shell
elaborate
designs
which
sustained-release
behaviors
molecules
can
be
intentionally
adjusted.
With
resveratrol
(RES)
as
a
model
poorly
water-soluble
cellulose
acetate
(CA)
PVP
polymeric
carriers,
brand-new
electrospun
nanostructure
was
fabricated
in
this
study.
The
guest
RES
host
CA
were
designed
to
have
reverse
gradient
distribution
within
nanostructures.
Scanning
electron
microscope
transmission
evaluations
verified
that
these
nanofibers
had
linear
morphologies,
without
beads
or
spindles,
an
obvious
double-chamber
structure.
X-ray
diffraction
patterns
Fourier
transform
infrared
spectroscopic
results
indicated
involved
components
highly
compatible
presented
amorphous
molecular
state.
In
vitro
dissolution
tests
new
structures
able
prevent
initial
burst
release,
extend
continuous-release
time
period,
reduce
negative
tailing-off
effect,
thus
ensuring
better
profile
than
traditional
blended
drug-loaded
nanofibers.
mechanism
underlying
influence
structure
RES/CA
on
proposed.
Based
proof-of-concept
demonstration,
series
advanced
functional
nanomaterials
similarly
developed
based
distributions
multi-chamber
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2614 - 2614
Опубликована: Сен. 15, 2024
Polymeric
composites
for
manipulating
the
sustained
release
of
an
encapsulated
active
ingredient
are
highly
sought
after
many
practical
applications;
particularly,
water-insoluble
polymers
and
core–shell
structures
frequently
explored
to
manipulate
behaviors
drug
molecules
over
extended
time
period.
In
this
study,
electrospun
nanostructures
were
utilized
develop
a
brand-new
strategy
tailor
spatial
distributions
both
insoluble
polymer
(ethylcellulose,
EC)
soluble
(polyvinylpyrrolidone,
PVP)
within
nanofibers,
thereby
extended-release
loaded
ingredient,
ferulic
acid
(FA).
Scanning
electron
microscopy
transmission
assessments
revealed
that
all
prepared
nanofibers
had
linear
morphology
without
beads
or
spindles,
those
from
coaxial
processes
obvious
structure.
X-ray
diffraction
attenuated
total
reflectance
Fourier
transform
infrared
spectroscopic
tests
confirmed
FA
fine
compatibility
with
EC
PVP,
presented
in
amorphous
state.
vitro
dissolution
indicated
radical
(decreasing
shell
core)
PVP
(increasing
able
play
their
important
role
elaborately.
On
one
hand,
F3
advantages
homogeneous
composite
F1
higher
content
solutions
inhibit
initial
burst
provide
longer
period
release.
other
F2
core
negative
tailing-off
The
key
element
was
water
permeation
rates,
controlled
by
ratios
polymers.
new
based
on
structure
paves
way
developing
wide
variety
polymeric
heterogeneous
realizing
desired
functional
performances.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9556 - 9556
Опубликована: Сен. 3, 2024
Personal
protective
equipment
(PPE)
has
attracted
more
attention
since
the
outbreak
of
epidemic
in
2019.
Advanced
nano
techniques,
such
as
electrospinning,
can
provide
new
routes
for
developing
novel
PPE.
However,
electrospun
antibacterial
PPE
is
not
easily
obtained.
Fibers
loaded
with
photosensitizers
prepared
using
single-fluid
electrospinning
have
a
relatively
low
utilization
rate
due
to
influence
embedding
and
their
inadequate
mechanical
properties.
For
this
study,
monolithic
nanofibers
core–shell
were
compared.
Monolithic
F1
fibers
comprising
polyethylene
oxide
(PEO),
poly(vinyl
alcohol-co-ethylene)
(PVA-co-PE),
photo-antibacterial
agent
vitamin
K3
(VK3)
created
blending
process.
Core–shell
F2
coaxial
which
extensible
material
PEO
was
set
core
section,
composite
consisting
PEO,
PVA-co-PE,
VK3
shell
section.
Both
designed
structural
properties
had
an
average
diameter
approximately
1.0
μm,
determined
scanning
electron
microscopy
transmission
microscopy.
amorphously
dispersed
within
polymeric
matrices
compatible
manner,
revealed
X-ray
diffraction
Fourier
transform
infrared
spectroscopy.
higher
tensile
strength
2.917
±
0.091
MPa,
whereas
longer
elongation
break
194.567
0.091%.
Photoreaction
tests
showed
that,
adjustment,
could
produce
0.222
μmol/L
·OH
upon
illumination.
slightly
better
performance
than
fibers,
inhibition
zones
1.361
0.012
cm
1.296
0.022
E.
coli
S.
aureus,
respectively,
but
less
VK3.
The
intentional
tailoring
components
compositions
nanostructures
improve
process–structure–performance
relationship
potential
sunlight-activated
Catalysts,
Год журнала:
2025,
Номер
15(2), С. 163 - 163
Опубликована: Фев. 11, 2025
The
excessive
use
of
ciprofloxacin,
an
antibiotic,
has
led
to
environmental
challenges
such
as
drug
resistance
and
severe
water
pollution,
necessitating
effective
mitigation
strategies.
Piezo-photocatalytic
technology
offers
a
sustainable
solution.
In
this
study,
BiVO4,
recognized
for
its
exceptional
visible
light
absorption
conductivity,
was
embedded
within
polyvinylidene
fluoride
(PVDF)
nanofibers
address
issues
secondary
pollution
enhance
material
recovery.
addition
peroxymonosulfate
(PMS)
further
improved
the
degradation
process
by
generating
highly
reactive
sulfate
radicals
(•SO4−),
which
acted
synergistically
with
piezoelectric
effects
pollutant
breakdown.
Under
combined
stir,
illumination,
PMS
activation,
BiVO4
achieved
40%
higher
ciprofloxacin
efficiency
compared
mechanical
stir
alone.
This
improvement
is
attributed
generation
polarization
charges
at
both
ends
•SO4−,
promoted
efficient
electron-hole
separation
oxidative
degradation.
study
introduces
novel
approach
piezo-photocatalytic
treatment
using
flexible
membrane
materials
enhancement.
Micromachines,
Год журнала:
2024,
Номер
15(10), С. 1226 - 1226
Опубликована: Сен. 30, 2024
Non-invasive
medical
nanofiber
technology,
characterized
by
its
high
specific
surface
area,
biocompatibility,
and
porosity,
holds
significant
potential
in
various
domains,
including
tissue
repair
biosensing.
It
is
increasingly
becoming
central
to
healthcare
offering
safer
more
efficient
treatment
options
for
contemporary
medicine.
Numerous
studies
have
explored
non-invasive
nanofibers
recent
years,
yet
a
comprehensive
overview
of
the
field
remains
lacking.
In
this
paper,
we
provide
summary
applications
electrospun
fields,
considering
multiple
aspects
perspectives.
Initially,
introduce
electrospinning
nanofibers.
Subsequently,
detail
their
health,
health
monitoring,
personal
protection,
thermal
regulation,
wound
care,
highlighting
critical
role
improving
human
health.
Lastly,
paper
discusses
current
challenges
associated
with
offers
insights
into
future
development
trajectories.
Nanomedicine,
Год журнала:
2024,
Номер
20(3), С. 271 - 278
Опубликована: Дек. 23, 2024
Electrospun
nanofibers
produced
through
single-fluid
blending
processes
have
successfully
demonstrated
their
potential
as
highly
effective
wound
dressings.
However,
electrospun
Janus
nanofibers,
in
which
various
chambers
can
be
designed
to
load
different
active
pharmaceutical
ingredients
into
polymeric
matrices,
are
further
exhibiting
versatility
for
promoting
healing.
This
commentary
declares
that
dressings
always
need
multiple
functional
performances
promote
unique
advantages,
with
parts
interacting
environments,
thereby
providing
a
versatile
platform
developing
novel
Two
recent
examples,
each
preparation
strategy
dressings,
discussed,
and
the
promising
future
of
dressing
applications
is
highlighted.
