Cubosomes and hexosomes stabilized by sorbitan monooleate as biocompatible nanoplatforms against skin metastatic human melanoma
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
677, С. 842 - 852
Опубликована: Авг. 16, 2024
Nanoparticles
have
become
versatile
assets
in
the
medical
field,
providing
notable
benefits
across
diverse
arenas
including
controlled
drug
delivery,
imaging,
and
immunological
assays.
Among
these,
non-lamellar
lipid
nanoparticles,
notably
cubosomes
hexosomes,
showcase
remarkable
biocompatibility
stability,
rendering
them
as
optimal
choices
for
theranostic
applications.
Particularly,
incorporating
edge
activators
like
sodium
taurocholate
enhances
potential
of
these
nanoparticles
dermal
transdermal
overcoming
stratum
corneum,
a
first
line
defense
our
skin.
This
study
reports
on
formulation
monoolein-based
hexosomes
stabilized
by
Span
80
co-encapsulating
Chlorin
e6
coenzyme
QH
photodynamic
therapy
skin
metastatic
melanoma.
The
formulations
were
optimized
using
small-angle
X-ray
scattering,
cryo-transmission
electron
microscopy
confirmed
presence
or
depending
ratio
between
80.
Furthermore,
co-loaded
exhibited
high
encapsulation
efficiencies
both
Ce6
QH.
In
vitro
studies
human
melanoma
cells
(Me45)
demonstrated
activity
loaded
formulations.
These
findings
show
possibility
formulating
more
biocompatible
cancer
treatment.
Язык: Английский
Liposomes and Niosomes: New trends and applications in the delivery of bioactive agents for cancer therapy
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
unknown, С. 124994 - 124994
Опубликована: Ноя. 1, 2024
Язык: Английский
Ethosomes as a new frontier and revolutionary approach for targeted skin cancer therapy
International Journal of Polymeric Materials,
Год журнала:
2025,
Номер
unknown, С. 1 - 22
Опубликована: Май 6, 2025
Язык: Английский
Mesoporous Silica Nanoparticles in Skin Cancer Therapy: Multifaceted Approaches in Drug Delivery
Khaled Ahmed,
Usama Ahmad,
Juber Akhtar
и другие.
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 107021 - 107021
Опубликована: Май 1, 2025
Язык: Английский
Synthesis, Molecular Docking, and Biological Activity of New EGFR-Targeted Photosensitizers Based on Cationic Porphyrins Encapsulated into Pluronic F127 Micelles
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 8, 2025
The
development
of
new
effective
photosensitizers
(PS)
for
photodynamic
therapy
(PDT)
is
one
the
important
tasks
in
medical
and
organic
chemistry.
PSs
inhibiting
epidermal
growth
factor
receptors
(EGFR)
overexpressed
cancer
cells
are
particular
importance.
In
this
work,
we
proposed
design
molecular
docking
novel
hybrid
based
on
meso-aryl-substituted
porphyrins
Erlotinib
molecule,
a
clinically
approved
tyrosine
kinase
inhibitor.
spacer
length
between
macrocycles
Erlotinib,
hydrophilicity,
hydrophobicity
porphyrin
ring
substituents
were
varied
obtained
compounds
to
evaluate
structure-activity
relationships
(SAR).
Photophysical
photochemical
characteristics
studied
all
received
presence
solubilizers
suitable
creation
dosage
forms.
Nanomicelles
Pluronic
F127
characterized
compounds.
vitro
biological
tests
three
cell
lines,
MCF-7
(breast
carcinoma),
A431
(epidermoid
MDA-MB-231
adenocarcinoma),
normal
NKE
(human
kidney
epithelial
cells)
performed,
which
showed
low
dark
toxicity
as
well
light-induced
activity
conjugates
nanomolar
range.
Confocal
microscopy
experiments
preferred
accumulation
UB-2
lower
UB-3
PSs.
case
UB-3,
observed
pronounced
colocalization
with
early
endosome
antigen
(EEA1).
Also,
apoptosis
inhibition
phosphorylation
EGFR
demonstrated
compound.
Thus,
targeting
PS
containing
cationic
pyridyl
moieties
linker
macrocycle
can
contribute
antitumor
PDT.
Язык: Английский
Enhanced fluorescence emission or singlet oxygen production of cationic porphyrazines and porphyrins through combination with carbon dots
Photochemistry and Photobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
Abstract
A
cationic
porphyrin
and
porphyrazine
with
the
3‐ethylpyridyl
substituent
(H
2
P
H
Pz)
their
respective
zinc
complexes
(ZnP
ZnPz)
were
assembled
to
a
carbon
dot
(CD)
synthesized
from
citric
acid
ammonium
citrate.
titration
was
performed
using
fluorescence
spectrophotometer
determine
stoichiometric
ratio
at
which
maximum
interaction
between
substances
occurs,
as
well
Stern–Volmer
constant
intrinsic
binding
constant.
The
combination
CD
porphyrins
or
porphyrazines
confirmed
UV–VIS
absorption
spectroscopy,
emission,
zeta
potential,
Diffusion‐Ordered
NMR
Spectroscopy
(DOSY).
It
observed
that
after
combination,
there
is
decline
in
of
derivatives,
variation
emission
porphyrazines,
subtle
increase
potential
compared
isolated
particles,
translational
diffusion
coefficient.
also
found
upon
CD,
changes
photophysical
properties
macrocycles
occur,
for
example,
quantum
yield
Pz
increases
0.81
±
0.03%
1.97
0.05%
while
singlet
oxygen
ca.
70%.
These
results
exemplify
capacity
boost
some
photosensitizers
are
key
photodynamic
therapy
applications.
Язык: Английский
Santali Albi Lignum: From traditional efficacy to pharmacological properties and modern therapeutics applications
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 120031 - 120031
Опубликована: Май 1, 2025
Язык: Английский
Engineered Cell‐Derived Nanovesicles with CAR and PH20 for Enhanced Targeted Photodynamic Cancer Therapy and Tumor Microenvironment Modulation
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment,
but
its
clinical
use
limited
by
nontargeted
photosensitizers
(PS)
that
accumulate
in
normal
tissues,
causing
adverse
effects,
and
poor
penetration
tumor
tissues
due
to
the
dense
extracellular
matrix
(ECM).
Here
an
innovative
approach
presented
using
cell‐derived
nanovesicles
(CNVs)
engineered
with
chimeric
antigen
receptor
(CAR)
hyaluronidase
PH20
enhance
targeted
PDT.
The
CAR–PH20
CNVs,
loaded
photosensitizer
pheophorbide
(PheoA),
specifically
target
HER2‐expressing
cells
degrade
hyaluronic
acid
microenvironment
(TME),
improving
drug
distribution.
In
vitro
vivo
experiments
demonstrate
increased
reactive
oxygen
species
(ROS)
generation,
improved
retention,
enhanced
therapeutic
efficacy
compared
conventional
methods.
When
combined
laser
irradiation,
these
CNVs
induce
significant
cell
apoptosis
inhibit
growth
mouse
models,
while
minimizing
toxicity
tissues.
This
platform
offers
strategy
for
targeted,
TME‐modulating
PDT
efficacy,
reduced
side
marking
advance
nanodrug‐based
therapies.
Язык: Английский