One-Pot Synthesis of Gelatin/Gum Arabic Hydrogels Embedding Silver Nanoparticles as Antibacterial Materials DOI Creative Commons
Irina Popescu, Irina Mihaela Pelin, Irina Roşca

и другие.

Gels, Год журнала: 2025, Номер 11(6), С. 429 - 429

Опубликована: Июнь 3, 2025

High and large-spectrum antibacterial features ROS scavenging properties are the most important requirements for efficient wound-dressing materials. A composite hydrogel was synthesized herein by a one-pot procedure embedding silver nanoparticles (AgNPs) covered with oxidized gum arabic (OGA) within gelatin (Gel) hydrogel. Small (2–20 nm), round-shaped AgNPs (ζ = −22 mV) were first obtained green synthesis using OGA as reducing capping agent. Composite hydrogels, containing 0.6 1.3 wt.% Ag, covalent cross-linking (Schiff base reaction) of amine groups in dialdehyde located on shell AgNPs. Thus, uniform distribution network contributed to increased physicochemical hydrolytic stability hydrogels. Moreover, high swelling degree together good mechanical make them appropriate candidates wound-healing The hydrogels exhibited 80% activity ABTS●+ free radicals after 6 h incubation effective against E. coli S. aureus, achieving 4% survival bacteria 3 (E. coli) 24 (S. aureus). These results clearly indicate that proposed have potential applications.

Язык: Английский

Recent advancements in the multifaceted biomedical efficacy of triazole based metal complexes DOI
Aman Kumar,

Seema Devi,

Sanjeev Kumar

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216675 - 216675

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

1
Cannabidiol-Based Thiosemicarbazones: A Preliminary Study Evaluating Their Anti-Tyrosinase Properties DOI Creative Commons

E Peretz,

Nissan Ashkenazi, Sanaa Musa

и другие.

Molecules, Год журнала: 2025, Номер 30(6), С. 1291 - 1291

Опубликована: Март 13, 2025

Cannabidiol (CBD), a non-psychoactive cannabinoid, has attracted significant research interest due to its antioxidant, anti-inflammatory, and neuroprotective properties. As versatile scaffold in drug discovery, CBD been widely explored for developing novel therapeutics. In this study, we synthesized evaluated the anti-tyrosinase activity of CBD-based thiosemicarbazones. Structure–activity relationship (SAR) analyses were conducted assess impact various functional groups on tyrosinase inhibition, including an evaluation inhibitory kinetics selected compounds. The derivatives demonstrated potent with comparable kojic acid, standard inhibitor. Given crucial role melanin biosynthesis, these findings suggest that thiosemicarbazones could serve as promising candidates managing tyrosinase-related disorders, hyperpigmentation melanogenesis-related conditions. Moreover, presence thiosemicarbazone moieties may contribute observed effects, potentially through metal chelation at enzyme’s active site. This study provides valuable insights into design CBD-derived inhibitors targeting tyrosinase. Further optimization in-depth biological are warranted explore their full therapeutic potential.

Язык: Английский

Процитировано

1
L-Cysteine Treatment Delays Leaf Senescence in Chinese Flowering Cabbage by Regulating ROS Metabolism and Stimulating Endogenous H2S Production DOI Creative Commons

Lin-Zhi Gan,

Zhen-liang Mou,

Jianye Chen

и другие.

Foods, Год журнала: 2024, Номер 14(1), С. 29 - 29

Опубликована: Дек. 25, 2024

Leaf senescence is a major concern for postharvest leafy vegetables, as leaves are highly prone to yellowing and nutrient loss, resulting in reduced commercial value limited shelf-life. This study aimed investigate the effect of L-cysteine (L-cys) on Chinese flowering cabbage stored at 20 °C. The results showed that 0.5 g L−1 L-cys treatment effectively slowed leaf by downregulating chlorophyll degradation genes (BrNYC1, BrNOL, BrPPH, BrPAO, BrNYE, BrSAGs) marker gene BrSAG12. Moreover, this exhibited positive influence nutritional quality cabbage. Also, maintained ROS homeostasis, preventing excessive accumulation lipid membrane oxidation. also higher total antioxidant capacity scavenging rate •OH O2•−. Additionally, high levels ascorbate glutathione activated enzymes (superoxide dismutase, peroxidase, catalase) expression encoding genes. Furthermore, elevated endogenous H2S levels, which correlated with increased desulfhydrase activity upregulation biosynthesis-related These findings suggest can delay reducing breakdown, maintaining stimulating production.

Язык: Английский

Процитировано

3
Green Synthesis of New Water‐Soluble Nickel (II) and Copper (II) Mixed‐Ligand Complexes: Characterization, DFT, In Vitro Biological Evaluation, and COVID‐19 Molecular Docking DOI Open Access
Mai M. Khalaf, Hany M. Abd El‐Lateef, Amro Ahmed Taha

и другие.

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(3)

Опубликована: Фев. 5, 2025

ABSTRACT This study presents the synthesis, characterization, and bioevaluation of novel water‐soluble nickel (NiMNPSCA) copper (CuMNPSCA) mixed‐ligand complexes. The complexes were synthesized in aqueous media using Ni (II) or Cu (II), sodium salicylate (SCA), a Schiff base derived from 2‐hydroxy naphthaldehyde (MNP). Comprehensive characterization was achieved UV–vis, IR spectroscopy, mass spectrometry, elemental analysis, thermal magnetic techniques. Both exhibited exceptional stability (melting points > 300°C), water solubility, 1:1 electrolyte behavior. Structurally, NiMNPSCA adopts tetrahedral geometry, while CuMNPSCA features an octahedral arrangement. Quantum chemical analyses revealed narrower energy gap ( ΔE = 3.06 eV) higher electrophilicity index ω 9.66) for CuMNPSCA, suggesting superior reactivity biological potential. demonstrated significantly enhanced antibacterial, antifungal, anti‐inflammatory activities compared to their free ligands, with showing efficacy comparable standard agents both antimicrobial applications. Notably, potent activity, achieving highest inhibition rate IC 50 value competitive ibuprofen. Molecular docking studies reinforced these findings, highlighting strong binding affinities dihydropteroate synthase (DHPS, PDB ID: 5JQ9; −8.00 kcal/mol), cyclooxygenase (COX, 6COX; −9.80 SARS‐CoV‐2 main protease (Mpro, 6LU7; −7.60 kcal/mol). Detailed interaction analysis that metal coordination complexes' through hydrogen bonds, π‐π stacking, π‐cation interactions. work positions as highly promising candidates antimicrobial, drug development, emerging standout compound therapeutic Its multifaceted bioactivity, combined robust structural reactivity, underscores its potential versatile agent, particularly resistance anti‐COVID‐19 strategies.

Язык: Английский

Процитировано

0
Design, synthesis of a novel Schiff base derivative with fluorescence behavior: a structural and DFT based study DOI

K. Pruthviraj,

R Chadrakumar,

Dinesh Babu NS

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141806 - 141806

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Fractional extraction of phenolics from seedless chestnut rose fruit: effects of solvent polarity on polyphenol composition and in vitro bioactivities DOI Creative Commons
Yan Hu, Yingying Feng, Hang Lü

и другие.

International Journal of Food Properties, Год журнала: 2025, Номер 28(1)

Опубликована: Март 24, 2025

Язык: Английский

Процитировано

0
Incorporation of co-encapsulated extracts of saffron petal and Stachys schtschegleevii into chitosan/basil seed gum/graphene oxide bionanocomposite: Effects on physical, mechanical, antioxidant, and antibacterial properties DOI

Hamid Rajabi,

Seyed Mohammad Ali Razavi

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 143116 - 143116

Опубликована: Апрель 15, 2025

Язык: Английский

Процитировано

0
Spectroscopic and Theoretical Elucidation of Acylthiourea Derivatives with Antioxidant and Low-Toxicity Profiles DOI
Adriana Castro Pinheiro,

Ana Paula Bonato Wille,

I. Nunes

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
One-Pot Synthesis of Gelatin/Gum Arabic Hydrogels Embedding Silver Nanoparticles as Antibacterial Materials DOI Creative Commons
Irina Popescu, Irina Mihaela Pelin, Irina Roşca

и другие.

Gels, Год журнала: 2025, Номер 11(6), С. 429 - 429

Опубликована: Июнь 3, 2025

High and large-spectrum antibacterial features ROS scavenging properties are the most important requirements for efficient wound-dressing materials. A composite hydrogel was synthesized herein by a one-pot procedure embedding silver nanoparticles (AgNPs) covered with oxidized gum arabic (OGA) within gelatin (Gel) hydrogel. Small (2–20 nm), round-shaped AgNPs (ζ = −22 mV) were first obtained green synthesis using OGA as reducing capping agent. Composite hydrogels, containing 0.6 1.3 wt.% Ag, covalent cross-linking (Schiff base reaction) of amine groups in dialdehyde located on shell AgNPs. Thus, uniform distribution network contributed to increased physicochemical hydrolytic stability hydrogels. Moreover, high swelling degree together good mechanical make them appropriate candidates wound-healing The hydrogels exhibited 80% activity ABTS●+ free radicals after 6 h incubation effective against E. coli S. aureus, achieving 4% survival bacteria 3 (E. coli) 24 (S. aureus). These results clearly indicate that proposed have potential applications.

Язык: Английский

Процитировано

0