A Mechanistic Experimental and Computational Exploration of Aldose Reductase Inhibition by Coumarins from Ruta chalepensis DOI
Emadeldin M. Kamel,

Doaa A. Abdelrheem,

Bashir Salah

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151946 - 151946

Опубликована: Май 1, 2025

Язык: Английский

Phytochemical Inhibitors of Squalene Epoxidase: Integrated In silico and In vitro Mechanistic Insights for Targeting Cholesterol Biosynthesis DOI
Emadeldin M. Kamel,

Doaa A. Abdelrheem,

Bashir Salah

и другие.

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер 768, С. 110372 - 110372

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

1
Comprehensive Insights into Carbonic Anhydrase Inhibition: A Triad of In vitro, In silico, and In vivo Perspectives DOI
Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

и другие.

Enzyme and Microbial Technology, Год журнала: 2025, Номер 189, С. 110657 - 110657

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
In vitro and In silico mechanistic insights into PTP1B inhibition by sulfated flavonoids from Flaveria bidentis DOI
Emadeldin M. Kamel,

Doaa A. Abdelrheem,

Fahad M. Alshabrmi

и другие.

Biocatalysis and Biotransformation, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Апрель 28, 2025

Язык: Английский

Процитировано

0
Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo implications DOI
Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

и другие.

Expert Opinion on Therapeutic Targets, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Squalene epoxidase (SQLE) is a pivotal enzyme in sterol biosynthesis, catalyzing the conversion of squalene to 2,3-oxidosqualene. Beyond its core role cholesterol homeostasis, SQLE implicated cancer, hypercholesterolemia, and fungal infections, positioning it as valuable therapeutic target. We conducted comprehensive literature search across primary databases gather vitro, silico, vivo evidence on SQLE. This review explores enzyme's structural functional features, including substrate specificity catalytic mechanisms, examines inhibitor interactions. Computational methods predict - dynamics, guiding drug design, while investigations clarify SQLE's metabolic disorders tumorigenesis. Challenges include resistance study discrepancies, but emerging technologies, such cryo-electron microscopy CRISPR editing, offer new avenues for deeper exploration. an underexplored yet promising target, with particular relevance oxidative stress, ferroptosis, gut microbiota research. Overcoming current barriers through advanced technologies multidisciplinary strategies could propel SQLE-targeted treatments into clinical practice, supporting precision medicine broader translational applications.

Язык: Английский

Процитировано

0
Unveiling the Molecular Mechanisms of Squalene Epoxidase Inhibition by Flavonoids from Erythrina speciosa: Integrative Computational and Experimental Insights DOI
Rasha H. Elsayed, Ayman M. Mahmoud, Sayed A. El‐Toumy

и другие.

Revista Brasileira de Farmacognosia, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Язык: Английский

Процитировано

0
A Mechanistic Experimental and Computational Exploration of Aldose Reductase Inhibition by Coumarins from Ruta chalepensis DOI
Emadeldin M. Kamel,

Doaa A. Abdelrheem,

Bashir Salah

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151946 - 151946

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0