Enantioselective synthesis of molecules with multiple stereogenic elements

Chemical Society Reviews, Год журнала: 2024, Номер 53(22), С. 11165 - 11206

Опубликована: Янв. 1, 2024

This review explores the fascinating world of molecules featuring multiple stereogenic elements, unraveling different strategies designed over years for their enantioselective synthesis.

Язык: Английский

Synthesis of All Ring Sizes of Medium-Sized Heterocycles Bridged Biaryls via VQM-Enabled Diversity-Oriented Synthetic Strategy

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Herein, for the first time, controllable, accurate, and diverse synthesis of all ring sizes medium-sized (8- to 11-membered) indole-derived bridged biaryls has been realized by using ingeniously designed o-alkynylnaphthols that feature cyclic amines with adjustable sizes. The transformation may proceed through a DBN-mediated in-situ generation vinylidene ortho-quinone methides/indole-ring formation/ring expansion cascade sequence, which is characterized acceptable excellent yields good functional group tolerance.

Язык: Английский

Construction of atropisomeric benzoxepinone-embedded styrenes via intramolecular [3+2] cycloaddition and catalytic kinetic resolution

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

We present an intramolecular [3+2] cycloaddition strategy to afford atropisomeric benzoxepinone-based styrenes, and then kinetic resolution was developed, giving the corresponding two types of axially chiral styrenes.

Язык: Английский