Conceptual expansion of photomedicine for spatiotemporal treatment methods

RSC Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review covers the history of light therapy, emergence photopharmacology, its methods, and challenges. Current advancements show promise for treating diseases like cancer with precision minimal side effects.

Язык: Английский

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Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 19, 2024

Abstract Molecular photoswitches can undergo isomerization under light exposure, making them uniquely attractive for high spatiotemporal resolution remote control of biological functions. Visible and near‐infrared (NIR) light, with their low energy consumption, safety, strong tissue penetration, are particularly suitable applications. Therefore, developing visible‐ NIR light‐driven molecular use is great significance. This review introduces the most common presents state‐of‐art applications in bioimaging, biosensing, drug delivery, photocontrolled cancer phototherapy, photopharmacology. The opportunities challenges future development outlined.

Язык: Английский

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Crystal Structure, Hirshfeld Surface Analysis, and Computational Insights into Phenoxyacetohydrazones: Hydrogen-Bonded Dimers and p-Stacking Interactions.

Journal of Molecular Structure, Год журнала: 2025, Номер 1333, С. 141752 - 141752

Опубликована: Фев. 16, 2025

Язык: Английский

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Stimuli-Responsive Lanthanide–Dianthracene Frameworks: Lanthanide-Dependent Photocycloaddition Reaction and Photophysical Properties

Crystal Growth & Design, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Metal–organic frameworks (MOFs) showing stimuli-responsive optical properties are very attractive due to their potential applications in information storage, molecular switches, and devices. In this work, we report a series of isomorphic lanthanide–dianthracene phosphonates with layered framework structures, namely, [Ln(NO3)3(depma2)1.5]·(depma2)0.5 (1Ln, Ln = Nd, Sm, Eu, Gd, Tb, Ho, Er, Tm, Yb), where depma2 stands for prephotodimerized 9-diethyl-phosphonomethylanthracene (depma). 1Ln experiences thermally induced single-crystal-to-single-crystal (SC–SC) structural transformation forming chain compound [Ln(NO3)3(depma)(depma2)]·(depma2)0.5 (2Ln) which one is dissociated into an anthracene pair. Interestingly, 2Ln (Ln Yb) exhibit excimer emission undergo [4 + 4] photocycloaddition SC–SC fashion form the pristine 1Ln, while others either display near-infrared (NIR) (for 2Nd, 2Er, 2Ho) or nonemissive 2Eu) do not reaction. Obviously, reversible photoresponsive luminescence can be achieved but Ho).

Язык: Английский

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Mechanism for the Indirect Photo‐transformation of Molecular Switches using a Pyrrolo‐pyrrole Two‐photon Absorbing Antenna

ChemPhotoChem, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract Electron‐rich symmetric pull‐push‐pull molecules can act as efficient two‐photon absorbing units. When these chromophores are bonded directly to photo‐switchable they function antenna systems indirectly induce photochemical transformations in isomerizable groups after energy transfer. Recently, we developed an antenna–molecular switch system based on a pyrrolo–pyrrole active chromophore. this section is functionalized with symmetrically situated azo‐sections N,N’‐pyrrolic‐substituents, azo molecular switches be efficiently transformed from their E Z isomers non‐linear light absorption by the antenna, followed indirect excitation of azo‐sections. In contribution present case‐study one through femtosecond‐resolved fluorescence observe dynamics involved and relaxation steps within section, well transfer pathways. By time‐resolving emission signals observed that occur parallel first singlet vibronic states localized at antenna. fact, antenna‐to‐azo shows biphasic nature. At early times, during there initial population azo‐section excited molecules. addition, has evolved fully relaxed S 1 state components related thermal fluctuations which increase couplings receiver azo‐switches giving rates order 10 s −1 room temperature. The characterization steps, role solvent processes, gives insights for development future isomerization properties using kind Due reactive properties, have applications schemes where highly photo‐isomerization required.

Язык: Английский

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All-Visible-Light-Activated Diarylethene Photoswitches

Molecules, Год журнала: 2024, Номер 29(21), С. 5202 - 5202

Опубликована: Ноя. 3, 2024

Photochromic compounds have attracted much attention for their potential applications in photo-actuators, optoelectronic devices and optical recording techniques. This interest is driven by key photochemical photophysical properties, which can be reversibly modulated light irradiation. Among them, diarylethene garnered extensive investigation due to excellent thermal stability of both open- closed-form isomers, robust fatigue resistance, high photocyclization quantum yield good photochromic performance solution solid phases. However, a notable limitation expanding the utility necessity ultraviolet induce photochromism. requirement poses challenges, as detrimental biological tissues, its penetration often restricted various media. review provides an overview design strategies employed development visible-light-responsive compounds. These serve guideline molecular design, with significantly broaden all-visible-light-activated realms materials science biomedical science.

Язык: Английский

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Kinetic Basis for the Design of Azobenzene-Based Photoswitchable A_2a Adenosine Receptor Ligands

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(47), С. 32670 - 32677

Опубликована: Ноя. 13, 2024

Photoisomerization of ligands is a key process in the field photopharmacology. Thus, kinetics and efficiency this initial photoreaction are great importance but can be influenced by molecular environment binding pocket resulting confinement reaction pathway. In study, we investigated photoisomerization an azobenzene derivative anti-Parkinson's drug istradefylline. To identify impact pocket, ligand was examined solution bound to its target protein, A

Язык: Английский

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Multilayer films for photon upconversion-driven photoswitching

Journal of Materials Chemistry C, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The use of triplet–triplet annihilation upconversion (TTA-UC) to drive photoswitching the energy-storing norbornadiene–quadricyclane (NBD–QC) isomers in solid-state is demonstrated.

Язык: Английский

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