Electrochemical umpolung of C‐H nucleophiles bearing three electron‐withdrawing groups to trigger radical 1,2‐alkylarylations of allylic alcohols

Advanced Synthesis & Catalysis, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Abstract The electrochemical catalyst‐free generation of carbon radicals bearing three electron‐withdrawing groups from the corresponding C−H nucleophiles remains unexplored. To this end, we report a direct electro‐oxidation strategy to access these electrophilic under conditions. Enabled by strategy, radical 1,2‐alkylarylations allylic alcohols was realized, affording β ‐quaternary ketones with high functional group compatibility. This protocol is operationally simple and also easy scale up.

Язык: Английский

Quinuclidine‐Catalyzed Electrochemical Minisci Acylation of N‐Heteroarenes with Acylhydrazines

ChemCatChem, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Abstract The quinuclidine (Qu)‐catalyzed activation of acylhydrazines to afford the corresponding acyl radicals remains an unmet challenge. To address this challenge, we report a synergistic strategy by combining electro‐oxidation with Qu‐based HAT catalysis. Enabled strategy, electrochemical Minisci acylation N ‐heterocycles was realized for first time.

Язык: Английский