Condition-Controlled Divergent Selective Synthesis of (Z)-N-Vinyl and N-Allenyl Benzimidazoles by Pd- or Bi-Catalyzed Direct N-Alkenylation Reactions

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

We have developed a condition-controlled divergent synthesis of (Z)-N-vinyl and N-allenyl benzimidazoles from 1,1,3-triphenylprop-2-yn-1-ols through Pd- or Bi-catalyzed N-alkenylation reactions involving nucleophilic attack C-C bond cleavage processes. The desired two different kinds products can be conveniently selectively synthesized by using this strategy, which features stereospecific synthesis, good functional group tolerance, broad substrate scope, high efficiency. strategy provides significant advantages for the biologically pharmaceutically active imidazoheterocycles.

Язык: Английский

Selective Alkylarylation Difunctionalization of 1,3-Butadienes via Nickel/Photoredox Dual Catalysis

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Photocatalytic multicomponent reactions are at the forefront of organic synthesis. In recent years, dicarbofunctionalization olefins has received significant attention, with nickel serving as a key transition metal catalyst under photochemical conditions. However, achieving regioselective 1,4-alkylarylation dienes alkyl and aryl bromides remains challenging. this work, we present Ni/photoredox dual catalysis approach for alkylarylation dienes, offering mild reaction that eliminates need stochiometric reductants. Broad substrate scope mechanistic investigations presented support proposed mechanism.

Язык: Английский