Silkworm Cocoon—Derived Carbon Dots for Post-Trauma Hemostasis and Tissue Repair DOI Creative Commons
Xinru Wu,

Miaomiao Yao,

Xuan Qiao

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 603 - 603

Опубликована: Апрель 22, 2025

Background: Traumatic hemorrhage management is challenging due to the need control severe bleeding and support tissue repair. An ideal material would possess both hemostatic wound-healing properties. Methods: Silkworm cocoon-derived carbon dots (SC-CDs) were synthesized via a hydrothermal method. After physical chemical characterization using techniques such as HR-TEM XPS, their efficacy was assessed in rat liver injury, tail transection, mouse coagulation disorder models. Moreover, effects of SC-CDs on platelet aggregation activation evaluated. The potential promote wound healing investigated through cell scratch assays full-thickness skin defect model. Results: showed high quantum yield (12.9% ± 0.42%), with low hemolytic activity cytotoxicity. In hemostasis models, significantly reduced time volume. injury model, shortened from 152.67 4.16 s (Control) 55.33 9.50 (p < 0.05). transection volume 1.71 0.16 g 0.4 0.11 an 8 mg/kg dose 11.80% 0.39% that Control Mechanistic studies suggested enhanced aggregation. experiments, area (88.53 11.78 mm2 vs. 70.07 6.71 (SC-CDs), p 0.05) promoted fibroblast migration (24 h width: 372.34 9.06 μm 259.49 36.75 Conclusions: show promise for regeneration, applications cases internal or disorders.

Язык: Английский

Silkworm Cocoon—Derived Carbon Dots for Post-Trauma Hemostasis and Tissue Repair DOI Creative Commons
Xinru Wu,

Miaomiao Yao,

Xuan Qiao

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 603 - 603

Опубликована: Апрель 22, 2025

Background: Traumatic hemorrhage management is challenging due to the need control severe bleeding and support tissue repair. An ideal material would possess both hemostatic wound-healing properties. Methods: Silkworm cocoon-derived carbon dots (SC-CDs) were synthesized via a hydrothermal method. After physical chemical characterization using techniques such as HR-TEM XPS, their efficacy was assessed in rat liver injury, tail transection, mouse coagulation disorder models. Moreover, effects of SC-CDs on platelet aggregation activation evaluated. The potential promote wound healing investigated through cell scratch assays full-thickness skin defect model. Results: showed high quantum yield (12.9% ± 0.42%), with low hemolytic activity cytotoxicity. In hemostasis models, significantly reduced time volume. injury model, shortened from 152.67 4.16 s (Control) 55.33 9.50 (p < 0.05). transection volume 1.71 0.16 g 0.4 0.11 an 8 mg/kg dose 11.80% 0.39% that Control Mechanistic studies suggested enhanced aggregation. experiments, area (88.53 11.78 mm2 vs. 70.07 6.71 (SC-CDs), p 0.05) promoted fibroblast migration (24 h width: 372.34 9.06 μm 259.49 36.75 Conclusions: show promise for regeneration, applications cases internal or disorders.

Язык: Английский

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