Navigating Unexplored Territories of the Interrupted Ugi and Passerini Reactions toward Peptidomimetics

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Interrupted reactions redirect established processes, often resulting in unexpected and novel outcomes. By employing a building block containing both acidic oxo functionalities tethered to the same carbon, we uncovered interrupted variants of Ugi Passerini reactions. More than 20 derivatives with peptide-like framework have been synthesized, demonstrating broad scope versatility these Additional studies explored use various nucleophiles postmodifications expand even more chemical diversity.

Язык: Английский

Strain-Releasing Hydrogenation of Donor–Acceptor Cyclopropanes and Cyclobutanes via Electrochemical Site Selective Carbonyl Reduction

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

An acid or hydrogen gas-free electrochemical protocol is established for the hydrogenation of strained rings (cyclopropane and cyclobutane) at room temperature atmospheric pressure. The mechanistic study revealed that reaction was initiated via reduction carbonyl group. methodology highly specific toward such as cyclopropane cyclobutane, which exhibit broad functional group tolerance.

Язык: Английский