Peptide Coacervates: Formation, Mechanism, and Biological Applications
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Biomolecular
coacervates,
dynamic
compartments
formed
via
liquid-liquid
phase
separation
(LLPS),
are
essential
for
orchestrating
intracellular
processes
and
have
emerged
as
versatile
tools
in
bioengineering.
Peptides,
with
their
modular
amino
acid
sequences,
exhibit
unique
potential
coacervate
design
due
to
ability
undergo
LLPS
while
offering
precise
control
over
molecular
architecture
environmental
responsiveness.
Their
simplicity,
synthetic
accessibility,
tunability
make
peptide-based
coacervates
particularly
attractive
biomedical
materials
applications.
However,
the
formation
stability
of
these
systems
depend
on
a
delicate
balance
intrinsic
factors
(e.g.,
sequence
charge,
hydrophobicity,
chain
length)
extrinsic
conditions
pH,
ionic
strength,
temperature),
necessitating
deeper
understanding
interplay.
This
review
synthesizes
recent
advances
mechanisms
driving
peptide
coacervation,
emphasizing
how
cues
govern
behavior.
We
further
highlight
groundbreaking
applications,
from
drug
delivery
platforms
protocell
mimics,
discuss
strategies
translate
mechanistic
insights
into
functional
materials.
By
bridging
fundamental
principles
innovative
this
work
aims
accelerate
development
programmable,
multifunctional
systems,
roadmap
next-generation
biochemical
technologies.
Язык: Английский
Peptide nanoarchitectonics beyond long-range ordering
Advances in Colloid and Interface Science,
Год журнала:
2025,
Номер
343, С. 103556 - 103556
Опубликована: Май 10, 2025
Язык: Английский
Phase Separation Pathways of Chiral Macromolecules at Liquid–Liquid Interfaces
Langmuir,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
The
phase
behavior
of
chiral
macromolecules
is
one
the
key
subjects
in
chemistry,
biology,
and
materials
science.
Here
we
take
poly(L-lactic
acid)
(PLLA)
mesomeric
poly(D,
L-lactic
(mPLA)
mixtures
as
a
model
system
investigate
separation
behaviors
double
emulsion
droplets.
At
high
mPLA
compositions,
creates
transient
bicontinuous
networks
or
discrete
domains
at
liquid-liquid
interface
eventually
generates
eyeball-like
microcapsules.
low
occurs
first
but
trapped
by
lateral
crystallization
PLLA,
leading
to
spindle-like
dynamic
pathways
can
be
further
modulated
PLA-based
amphiphilic
block
copolymers,
so
that
microcapsules
are
configurable
between
eyeball-,
spindle-,
Janus-like
structures.
By
comparing
with
on
plane
substrate,
unveil
dynamics
interfaces
significantly
affected
interfacial
properties
hydrodynamic
effects.
This
work
clarifies
transition
PLLA/mPLA
sheds
insight
into
for
their
structural
modulation.
Язык: Английский
Lactylation-regulated biomolecular condensates: metabolic control of phase separation in physiology and disease
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 25, 2025
Lactate
has
long
been
viewed
as
a
"waste
product"
of
anaerobic
glycolysis,
with
its
role
in
health
and
disease
often
overlooked.
However,
recent
discoveries
lactylation-a
novel
post-translational
modification
involving
lactate-have
sparked
renewed
understanding
lactate's
functions.
Lactylation
alters
the
molecular
structure
proteins
different
cellular
localizations,
enabling
regulation
their
functions
aggregation
specific
spatiotemporal
contexts,
impact
on
biomolecular
phase
separation
being
one
primary
effects.
it
remains
unknown
how
lactylation
dynamically
regulates
specificity
diseases.
This
article
provides
an
overview
regulatory
mechanisms
driven
by
lactylation,
aiming
to
offer
fresh
insights
into
normal
disease-related
biological
processes
while
deepening
our
research
value
significance.
Язык: Английский