Metal‐Coordinated Polydopamine Structures for Tumor Imaging and Therapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(28)

Опубликована: Июль 17, 2024

Meticulously engineered nanomaterials achieve significant advances in the diagnosis and therapy of solid tumors by improving tumor delivery efficiency; thereby, enhancing imaging therapeutic efficacy. Currently, polydopamine (PDA) attracts widespread attention because its biocompatibility, simplicity preparation, abundant surface groups, high photothermal conversion efficiency, which can be applied drug delivery, therapy, theranostics, other nanomedicine fields. Inspired PDA structures that are rich catechol amino functional groups coordinate with various metal ions, have charming qualities characteristics, metal-coordinated exploited for but not thoroughly summarized. Herein, this review summarizes recent progress fabrication their availabilities further in-depth discussion challenges future perspectives structures, aim systematic promote interdisciplinary intersections provide inspiration growth clinical translation materials.

Язык: Английский

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Octa-Cationic Porphyrin-Functionalized Biocompatible Nanocomposite: A Promising Candidate for Enhanced Combinatorial Photodynamic and Photothermal Tumor Therapy

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

The integration of photodynamic therapy (PDT) and photothermal (PTT) offers a promising strategy for enhancing phototherapy efficiency. Herein, we present dual-functional, biocompatible nanocomposite system combination PDT/PTT therapy. utilizes highly nanoparticle assembled by an amphiphilic short peptide with the assistance Zn2+ as carrier. convertor is loaded within nanoparticle, while cationic porphyrin photosensitizer on surface. water-soluble (M8PzEOPP), designed eight positive charges, provides strong electrostatic interaction stable assembly This location-independent effectively maintains optical characteristics both convertor, endowing effective properties. exhibits excellent tumor-targeting accumulation behavior, low dark toxicity, robust extracellular biostability, high cell internalization Its enhanced performance in combinatorial demonstrated through vitro vivo experiments.

Язык: Английский

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Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(25), С. 6091 - 6101

Опубликована: Янв. 1, 2024

Due to the rapid progression and aggressive metastasis of breast cancer, its diagnosis treatment remain a great challenge. The simultaneous inhibition tumor growth is necessary for cancer obtain ideal therapeutic outcomes. We herein report development radioactive hybrid semiconducting polymer nanoparticles (SPNH) imaging-guided tri-modal therapy cancer. Two polymers are used form SPNH with diameter around 60 nm via nano-coprecipitation they also labeled iodine-131 (131I) enhance imaging functions. formed show good radiolabeling stability excellent photodynamic photothermal effects under 808 laser irradiation produce singlet oxygen (1O2) heat. Moreover, can generate 1O2 ultrasound their sonodynamic properties. After intravenous tail vein injection, effectively accumulate in subcutaneous 4T1 tumors living mice as verified fluorescence single photon emission computed tomography (SPECT) imaging. With using an US, mediate (PDT), (PTT) (SDT) kill cells. Such leads improved efficacy inhibiting suppressing compared sole SDT combinational PDT-PTT. This study thus demonstrates applications diagnose combine different therapies effective treatment.

Язык: Английский

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Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Infected bone defects, caused by bacterial contamination following disease or injury, result in the partial loss destruction of tissue. Traditional transplantation and other clinical approaches often fail to address therapeutic complexities these conditions effectively. In recent years, advanced biomaterials have attracted significant attention for their potential enhance treatment outcomes. This review explores pathogenic mechanisms underlying infected including biofilm formation internalization into cells, which allow bacteria evade host immune system. To control infection facilitate repair, we focus on antibacterial materials regeneration. A detailed introduction is given intrinsically (e.g., metal alloys, oxide materials, carbon-based hydroxyapatite, chitosan, Sericin). The functionality repair can be enhanced through strategies such as incorporation antimicrobial ions, surface modification, combined use multiple treat defects. Key innovations discussed include that release agents, functional contact biomaterials, bioresponsive collectively efficacy. Research translation has also facilitated practical application prevention healing. conclusion, advancements provide promising pathways developing more biocompatible, effective, personalized therapies reconstruct

Язык: Английский

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A CXCR4-targeted immunomodulatory nanomedicine for photodynamic amplified immune checkpoint blockade therapy against breast cancer

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Advanced Strategies for Strengthening the Immune Activation Effect of Traditional Antitumor Therapies

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4701 - 4715

Опубликована: Июль 3, 2024

The utilization of traditional therapies (TTS), such as chemotherapy, reactive oxygen species-based therapy, and thermotherapy, to induce immunogenic cell death (ICD) in tumor cells has emerged a promising strategy for the activation antitumor immune response. However, limited effectiveness most TTS inducing ICD effect tumors hinders their applications combination with immunotherapy. To address this challenge, various intelligent strategies have been proposed strengthen these TTS, then achieve synergistic efficacy These primarily focus on augmenting or facilitating antigen (released by cells) presentation process during they are systematically summarized review. Finally, existing bottlenecks prospects application regulation also discussed.

Язык: Английский

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Aggregation-Induced Emission: Application in Diagnosis and Therapy of Hepatocellular Carcinoma

Biosensors and Bioelectronics, Год журнала: 2024, Номер 266, С. 116722 - 116722

Опубликована: Авг. 29, 2024

Язык: Английский

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Multimodal Photodynamic Therapy by Inhibiting the Nrf2/ARE Signaling Pathway in Tumors

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(11), С. 7018 - 7029

Опубликована: Окт. 17, 2024

Photodynamic therapy (PDT) has been widely used in the clinical of various tumors, especially superficial tumors. However, tumor microenvironment presents hypoxia, as well inherent antioxidant system (e.g., Nrf2) cells limits therapeutic outcomes. Herein, a cascade-responsive "oxidative stress amplifier" (named EZ@TD) is designed by encapsulating manganese-doped carbon dots acting photosensitizer and catalase (CAT)-like nanozyme within pH-sensitive ZIF-8 Zn2+-activated DNAzyme for relieving hypoxia efficient Nrf2 gene disruption to enhance PDT. It demonstrated that EZ@TD synergistically inhibited growth activated antitumor immune response inhibiting Nrf2/ARE signaling pathway We provide new paradigm amplifying intracellular oxidative interfering with pathways.

Язык: Английский

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Novel Flavin Mononucleotide-Functionalized Cerium Fluoride Nanoparticles for Selective Enhanced X-Ray-Induced Photodynamic Therapy

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 373 - 373

Опубликована: Дек. 10, 2024

X-ray-induced photodynamic therapy (X-PDT) represents a promising new method of cancer treatment. A novel type nanoscintillator based on cerium fluoride (CeF3) nanoparticles (NPs) modified with flavin mononucleotide (FMN) has been proposed. for synthesizing CeF3-FMN NPs developed, enabling the production colloidal, spherical an approximate diameter 100 nm, low polydispersity, and high fluorescence quantum yield 0.42. It demonstrated that exhibit pH-dependent radiation-induced redox activity when exposed to X-rays. This results in generation reactive oxygen species, which is associated scintillation properties transfer electrons FMN. The synthesized have minimal cytotoxicity towards normal cells (NCTC L929 fibroblasts) but are more toxic tumor (epidermoid carcinoma A431). Concurrently, (CeF3 NPs) demonstrate pronounced selective radiosensitizing effect at concentrations 10−7 10−3 M, resulting significant reduction their clonogenic activity, increasing radiosensitivity by 1.9 times following X-ray irradiation dose 3 6 Gy. In context cells, these serve function antioxidants, maintaining level activity. Functional nanoscintillators basis can be used as part latest technologies treatment tumors within framework X-PDT.

Язык: Английский

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Tumor-targeted nanosystem with hypoxia inducible factor 1α inhibition for synergistic chemo-photodynamic therapy against hypoxic tumor

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 248, С. 114456 - 114456

Опубликована: Дек. 13, 2024

Язык: Английский

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