Materials chemistry horizons., Год журнала: 2024, Номер 3(3), С. 1 - 10
Опубликована: Дек. 1, 2024
Язык: Английский
Nano Select, Год журнала: 2024, Номер unknown
Опубликована: Окт. 18, 2024
ABSTRACT Photothermal therapy (PTT) has emerged as a promising alternative to conventional cancer treatments such radiation therapy, chemotherapy, and surgery. PTT uses light‐absorbing nanomaterials induce localized hyperthermia selectively eliminate cells, thus offering advantages over traditional interventions. This literature review focuses on nanoparticles for PTT, their heating properties, functions in theragnostic applications photothermal treatment. It highlights the fundamental principles, recent spectroscopic developments diagnosis treatment monitoring, clinical advancements near‐infrared (NIR) nanoparticle‐mediated emerging numerical methods preclinical planning of PTT.
Язык: Английский
Процитировано
7
Carbohydrate Polymers, Год журнала: 2024, Номер 351, С. 123136 - 123136
Опубликована: Дек. 11, 2024
Язык: Английский
Процитировано
5
Smart Materials in Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
0
Bioconjugate Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Over past decades, a wide range of nanomaterials have been synthesized and exploited to augment the efficacy biocompatibility disease theranostics nanomedicine. The unique physicochemical properties nanomaterials, such as high specific surface area, tunable size shape, versatile chemistry, enable controlled modulation nanomaterial-biosystem interactions and, consequently, more precise interventions, particularly at cellular level. selective nanomaterial-cell can be leveraged regulate internalization, intracellular trafficking localization, clearance enhance therapeutic minimize potential cytotoxicity. Herein, we provide an overview our recent understanding journey modes action in cells. Specifically, highlight various pathways trafficking, excretion these nanomaterials. different especially release delivery, photothermal photodynamic effects, immunomodulation, are also discussed. We conclude review by offering some perspectives on current challenges opportunities this field.
Язык: Английский
Процитировано
0
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)
Опубликована: Апрель 1, 2025
ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216781 - 216781
Опубликована: Май 21, 2025
Язык: Английский
Процитировано
0
Sensors, Год журнала: 2025, Номер 25(11), С. 3312 - 3312
Опубликована: Май 24, 2025
The world urgently needs new methods to quickly and efficiently detect mutated viruses. An RNA-AuNP-based colorimetric biosensor is a highly sensitive, specific, cost-effective tool that enables rapid, visual detection of target molecules for applications in disease diagnostics, environmental monitoring, forensic analysis. requires precise control over nanoparticle dispersion aggregation, which can be achieved using temperature regulation. A novel on-chip microelectrode proposed induce monitor the aggregation RNA-attached gold nanoparticles (AuNPs) through Joule heating impedance spectroscopy. platform implemented based on printed circuit board (PCB) technology, has many advantages, such as fast easy design fabrication, low power consumption, costs. process energy an electric current converted into heat it flows resistance. Impedance spectroscopy analytical technique measures system’s electrical response applied AC signal across range frequencies, providing insights sample’s dielectric properties. results validate fabricated capable 20 µL droplet 75 °C within 30 s, utilizing input only 3.75 watts successfully inducing color change presence hepatitis C virus (HCV) RNA, while readings are used aggregation.
Язык: Английский
Процитировано
0
Journal of the American Chemical Society, Год журнала: 2025, Номер unknown
Опубликована: Май 30, 2025
Assembly of plasmonic nanoparticles (NPs) generates unique optical properties through coupling the localized surface plasmon resonance (LSPR) individual NPs. However, precisely controlling and monitoring how mesoscale assembly dictates final remain key challenges in designing advanced materials. Here, we introduce "nanoplasmonic isosbestics" as descriptors organization gold (AuNPs) on soft templates. Unlike isosbestic points molecular spectroscopy, which describe chemical equilibria, our numerical simulations demonstrate that nanoplasmonic isosbestics emerge from coexistence AuNPs AuNP clusters, where interparticle spacing determines wavelength. By templating onto synthetic free-standing lipid bilayers with tunable membrane rigidity, experimentally achieve precise control over prove it is mirrored by univocal modulation This provides a fundamental understanding structure-function relationship systems, linking, for first time, to equilibrium structure assemblies. On analytical perspective, provide noninvasive fingerprints templates, opening appealing applications. As proof concept, apply this approach profile stiffness two extracellular vesicle (EVs) classes─mesenchymal stem cell (MSC)-derived red blood cell-derived EVs─both recognized their biological translational potential.
Язык: Английский
Процитировано
0
BMC Biotechnology, Год журнала: 2024, Номер 24(1)
Опубликована: Дек. 24, 2024
Breast cancer, a formidable global health challenge for women, necessitates innovative therapeutic strategies with enhanced efficacy and minimal side effects. Aripiprazole (ARI), widely used schizophrenia medication, exhibits promising potential in the treatment of breast cancer. As cancer therapy evolves towards combination approach, multimodal nano-based delivery systems, such as ARI-loaded niosomes (NIOs) combined Chitosan-Au nanoparticles chemo-photothermal therapy, show promise over traditional chemotherapy alone by enhancing targeted minimizing In this study, niosomal formulation was designed, incorporating ARI chitosan-coated AuNPs (i.e. NIOs/AuNPs-CS/ARI), to study synergistic effect photothermal/chemotherapy cells. The nanosystems were characterized using UV-Vis spectroscopy Fourier-transform infrared (FT-IR), confirming successful synthesis steps. hydrodynamic diameter NIOs/AuNPs-CS determined be 44.62 nm zeta -0.836. Also, Transmission Electron Microscopy (TEM) Field-Emission Scanning Microscopical (FE-SEM) analysis performed assess size morphology NPs. loading efficiency NIOs NIOs/AuNPs–CS 75% 88%, respectively. Furthermore, release rate drug from is higher than blank at two pH values (5.8 7.4). cellular uptake AuNPs-CS-encapsulated considerably that NIOs. Annexin V/PI staining assay showed apoptosis/necrosis high NIOs/AuNPs-CS/ARI (46%) NIOs/ARI (36%) 48 h. results MTT assessments demonstrated cytotoxicity viability MCF-7 cells treated reduced 60% 50% 40% 20%, respectively, after 24 h upon laser irradiation. experiment remarkable effectiveness treatment, owing their unique properties, including PTT capability sensitivity.
Язык: Английский
Процитировано
2