Pathophysiology-Informed Design of Negatively Charged Liposomes for Enhanced Antibiotic Delivery across the Intact Tympanic Membrane in Acute Otitis Media Treatment

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Acute otitis media (AOM) is a leading cause of oral antibiotic prescriptions for children in the U.S., often resulting systemic side effects and contributing to resistance. Local delivery antibiotics across an intact tympanic membrane (TM) treat infection middle ear challenging due impermeable TM, which blocks most molecules via outermost stratum corneum layer. Recent research has identified liposomes encapsulating as highly promising approach overcoming TM during AOM, demonstrating superior efficiency. However, their design principles remain elusive, especially regarding desirable surface charge. While previous positive charge being more effective crossing healthy corneum, this study illustrates opposite true infection. We compared hydrogel formulations containing positively negatively charged terms vitro release, permeation ex vivo, vivo AOM treatment efficacy, tissue-level biocompatibility using established chinchilla model. Our results indicate that outperformed ones, successfully eradicating 100% cases. attributed interactions between immune response Specifically, complement activation, triggers neutrophils' phagocytosis, enhanced liposomes. findings highlight opportunity improve efficiency by considering pathophysiology wholistically drug vehicles.

Язык: Английский

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Abstract The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well a huge social burden. Among these caused by inner ear lesions accounts for large proportion. Therefore, treatment the important. Inner drug delivery systems, which can reduce side effects systemic administration delivering drugs directly ear, are important in sensorineural loss. Here, development systems focused, including complex physiological structure that they face, types delivered, routes administration, forms carrier platforms. Recent studies this process presented it concluded summary outlook on problems faced possible solutions.

Язык: Английский

Ototoxic effects of unilateral postauricular neomycin administration on the inner ears of Guinea pigs

Acta Oto-Laryngologica, Год журнала: 2024, Номер unknown, С. 1 - 8

Опубликована: Дек. 11, 2024

Due to the therapeutic needs of inner ear diseases, a simple method drug delivery has been under exploration. Postauricular administration, which involves injecting through middle retroauricular groove, is potential novel approach, but its mechanisms remain unclear.

Язык: Английский