A Review on Bioengineering the Bovine Mammary Gland: The Role of the Extracellular Matrix and Reconstruction Prospects

Bioengineering, Год журнала: 2025, Номер 12(5), С. 501 - 501

Опубликована: Май 9, 2025

The mammary gland is a modified sweat responsible for milk production. It affected by diseases that reduce animals’ quality of life, consequently leading to economic losses in livestock. With advancements tissue bioengineering and regenerative medicine, studying the extracellular matrix (ECM) bovine can improve our understanding its physiology processes affect it. This knowledge could also enable development sustainable therapeutic alternatives both dairy production chain human oncology research. A common approach medicine decellularization, process removes all cells from while preserving architecture ECM components subsequent recellularization. success recellularization depends on obtaining immunologically compatible scaffolds using appropriate cell culture sources methods ensure functionality. However, technology still faces challenges due specific requirements high costs. Here, we review literature biomaterials engineering, providing an overview advances bioengineering, with focus species. methodology employed consists structured search scientific databases, including PubMed, Google Scholar, SciELO, keywords related engineering gland. selection criteria prioritized peer-reviewed articles published between 2002 2025 demonstrated relevance contributed bioengineering. Although research this topic has advanced, vascularization, maturation, scalability remain key barriers widespread application viability.

Язык: Английский

In Silico Discovery of Multi-Target Small Molecules and Efficient siRNA Design to Overcome Drug Resistance in Breast Cancer via Local Therapy

Journal of Molecular Graphics and Modelling, Год журнала: 2025, Номер 140, С. 109086 - 109086

Опубликована: Май 20, 2025

Язык: Английский