Fabrication and Characterization of a Stretchable Sodium Alginate Hydrogel Patch Combined with Silicon Nitride and Metalized Halloysite Nanotubes to Develop a Chronic Wound Healing Treatment

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1734 - 1734

Опубликована: Фев. 18, 2025

The human body is known as a responsive healing machine, but sometimes, broken bones do not heal, especially if bacterial infection present. present study describes the fabrication and characterization of nanocomposite hydrogel patch incorporated with silicon nitride magnesium oxide (MgO) deposited on halloysite nanotube (HNT) surface using facile inexpensive electrodeposition coating process. Scanning electron microscopy (SEM) was used to observe morphology MgO/HNT patch. Material characterization, including SEM, contact angle, pore size analysis, tensile properties, performed determine composite's structure material properties. E. coli S. aureus cultures were test antimicrobial Cellular response MgO/HNTs studied mouse embryonic fibroblasts. discovered possess inherent properties when tested against cultures, it found enhance fibroblast cell migration proliferation. also showed sustained drug release. Materials involved in helped swelling by which has approximately 400% its initial weight during test.

Язык: Английский

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Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review

Materials, Год журнала: 2024, Номер 17(19), С. 4792 - 4792

Опубликована: Сен. 29, 2024

Hydrogels, known for their unique ability to retain large amounts of water, have emerged as pivotal materials in both tissue engineering and biosensing applications. This review provides an updated comprehensive examination cutting-edge hydrogel technologies multifaceted roles these fields. Initially, the chemical composition intrinsic properties natural synthetic hydrogels are discussed, highlighting biocompatibility biodegradability. The manuscript then probes into innovative scaffold designs fabrication techniques such 3D printing, electrospinning, self-assembly methods, emphasizing applications regenerating bone, cartilage, skin, neural tissues. In realm biosensing, hydrogels’ responsive nature is explored through integration optical, electrochemical, piezoelectric sensors. These sensors instrumental medical diagnostics glucose monitoring, pathogen detection, biomarker identification, well environmental industrial like pollution food quality monitoring. Furthermore, explores cross-disciplinary innovations, including use wearable devices, hybrid systems, potential personalized medicine. By addressing current challenges future directions, this aims underscore transformative impact advancing healthcare practices, thereby providing a vital resource researchers practitioners field.

Язык: Английский

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Topical transferosomal gel of berberine HCl and diacerein reduced TNF-α and IL-17A levels and reduced epidermal thickness in imiquimod-induced psoriatic BALB/c mice

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106731 - 106731

Опубликована: Фев. 1, 2025

Язык: Английский

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3D-printed gelatin/dialdehyde starch hydrogels for hydrocortisone topical administration and in vivo treatment of atopic dermatitis

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 251, С. 114613 - 114613

Опубликована: Март 7, 2025

Язык: Английский

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In Vitro Studies of the Effect of Oil Emulsions from Transgenic Flax Varieties on the Treatment of Wound Healing and Care of Human Skin with the Tendency to Inflammation

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2544 - 2544

Опубликована: Март 12, 2025

Excessive amounts of free-oxygen radicals produced during inflammation induce oxidative stress and lead to cell damage, thus delaying the transition into proliferation in wound healing process. Oxidative on skin cells also plays an important role pathogenesis inflammatory diseases. The aim planned vitro studies was assess mechanisms regenerative action protection against three oil emulsions from transgenic (GMO) flax varieties M, B, MB a linseed emulsion traditional NIKE oil. Antioxidant gene-protective properties were identified for tested healthy model under stress. wound-healing potential these assessed proliferation, cycle, migration, apoptosis necrosis assays. conducted research presented that are safe human because they do not cancer and, at same time, migration processes normal cells. Additionally, their use increases ability eliminate damaged Transgenic oils provide effect increased antioxidant effect, resulting stress, which atopic dermatitis psoriasis. Linen B has best protective epidermis cancer, is probably due presence amount stigmasterol its composition along with appropriate content polyphenol compounds, as well oleic linoleic acids.

Язык: Английский

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Immune Memory: A New Frontier in Treating Recurrent Inflammatory Skin Diseases

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Март 18, 2025

Язык: Английский

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Assessment of physicochemical properties of polysaccharide derived mucoadhesive hydrogels to design tunable drug delivery carriers

Medicine in Novel Technology and Devices, Год журнала: 2025, Номер unknown, С. 100360 - 100360

Опубликована: Март 1, 2025

Язык: Английский

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Exploring the potential of biopolymers in cosmetic applications: Sustainable, biocompatible, and high‐performance materials for future innovations

Polymer Engineering and Science, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Abstract Concerns over the potential health risks and environmental impact of synthetic cosmetic ingredients have led to a growing demand for safer, eco‐friendly alternatives. Biopolymers, derived from natural sources, offer unique advantages, including biodegradability, biocompatibility, nontoxicity, making them ideal candidates formulations. Their ability form hydrogels, films, emulsions allows versatile applications, while their superior water retention moisture‐binding properties make valuable in skin hydration anti‐aging products. This review provides comprehensive analysis current use biopolymer‐based materials cosmetics, focusing on physicochemical address key industry challenges. It highlights hyaluronic acid, alginate, chitosan as most frequently utilized biopolymers, given significant roles hydration, active ingredient encapsulation, barrier enhancement. The these other biopolymers replace polymers, offering safer more sustainable option consumers, is also explored. By identifying gaps research outlining latest advancements, this aims promote further innovation development materials, ultimately contributing effective solutions. Highlights Biopolymeric solutions They enable biocompatible innovations. Controlled release actives via biopolymer matrices cosmetics. Advanced systems improve delivery efficacy

Язык: Английский

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Targeted Drug Delivery System for Pulmonary Fibrosis: Design and Development of Biomaterials

BIO Integration, Год журнала: 2025, Номер 6(1)

Опубликована: Янв. 1, 2025

Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by excessive extracellular matrix deposition and tissue scarring, leading to impaired function respiratory failure. Although current treatments, such as pirfenidone nintedanib, slow progression, they fail completely halt or reverse fibrosis. Therefore, innovative therapeutic strategies are needed. Targeted drug delivery systems (TDDSs) emerging promising solutions. Biomaterials play critical roles in these enhancing specificity, availability, efficacy, while minimizing systemic toxicity. The most notable biomaterials include nanotechnology-based systems, including liposomes polymeric nanoparticles, which facilitate penetration release fibrotic tissues. Hydrogels have three-dimensional structures providing controlled sustained at inflammation sites, therefore particularly valuable PF treatment. Furthermore, biological carriers stem cells vesicles biocompatibility anti-inflammatory effects that improve outcomes. Despite the potential of clinical translation hindered several challenges, immune clearance, stability platforms, optimization retention within diseased Interdisciplinary approaches integrating precision medicine with advancements may provide solutions opening new avenues for This review discusses developments targeted PF, emphasizing importance biomaterials, mechanisms barriers involved pulmonary delivery, future perspectives overcoming limitations. ultimate goal patient outcomes revolutionizing approach treatment through advanced technologies.

Язык: Английский

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Advances in cellulose-based hydrogels: tunable swelling dynamics and their versatile real-time applications

RSC Advances, Год журнала: 2025, Номер 15(15), С. 11688 - 11729

Опубликована: Янв. 1, 2025

Cellulose-derived hydrogels have emerged as game-changing materials in biomedical research, offering an exceptional combination of water absorption capacity, mechanical resilience, and innate biocompatibility.

Язык: Английский

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