Can Conformational Flexibility Influence the Self-Assembly Behavior and Sensing Efficacy of Fluorogenic Amphiphiles? A Case Study with Bisbenzimidazole based Probes DOI

Suraj Pise,

Imran Ahmad, Nilanjan Dey

и другие.

Analytical Methods, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 13, 2024

In this work, we have explored the metal ion sensing properties of two bisbenzimidazole-based fluorescent probes, that differ in their conformational flexibility, an aqueous medium. The compound with a flexible methyl spacer (1) experienced blue shifts its absorption and emission maxima (along turn-off response) upon addition Hg2+ ions. On contrary, relatively rigid structure (2) showed red both when treated under similar conditions. Detailed mechanistic studies indicated 1 formed : 2 complex ions, where pyridine nitrogen ends benzimidazole units are involved coordination. However, for 2, binding stoichiometry changed to ions remained connected only through ends. Not did changes molecular level interactions alter optical response, but they also altered efficacy sensing; degree response was more prominent than 2. Also, it observed could dissociate preformed aggregated structures 1, while case promotes aggregate formation. sensor further utilized analysis real-life water samples detection intracellular conditions (HeLa cells).

Язык: Английский

Enhancing elevated temperature performance of alkali activated slag-dolomite concrete with Fly ash DOI

Arjun Raj P.K.,

Ravi Joshi,

D Sarath

и другие.

Physics and Chemistry of the Earth Parts A/B/C, Год журнала: 2025, Номер 138, С. 103857 - 103857

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

1

Conformational Stability of α-Lactalbumin and Lysozyme in Ammonium-Based Ionic Liquids: A Comprehensive Insight into Structure–Activity Relationship DOI
S. K. Patra,

Poonam Singh,

Dharmendra Singh

и другие.

Industrial & Engineering Chemistry Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

Процитировано

1

Unravelling Optical Properties and Self-Assembly Behavior of Ciprofloxacin in Ionic Liquid Environments: Probing the Role of Cationic Residues and Counter Anions DOI
S. K. Patra, Nilanjan Dey

Dalton Transactions, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This study investigated the interaction of ciprofloxacin (CIP) with three different ionic liquids (ILs) featuring distinct cationic residues (pyrrolidinium, IL1, vs. imidazolium, IL2, bis(trifluoromethylsulfonyl)imide as counter anion) and anions bis(trifluoromethylsulfonyl)imide, hexafluorophosphate, IL3, imidazolium residue) in an aqueous environment. A series spectroscopic studies have been performed to elucidate role ILs optical properties well aggregation behavior CIP. The fluorescence quenching experiment indicated that IL a pyrrolidinium residue showed stronger binding CIP, while was preferred anion. These effects might be attributed complex formation mediated by charge-pair cation-π interactions, along hydrogen bonding. Stern-Volmer analysis confirmed static mechanism, constants (Kb) reflecting affinity IL1 due hydrophobic butyl group flexible cation, resulting larger aggregates. In contrast, IL2 facilitated π-π hydrogen-bond disrupting CIP smaller clusters. polarizable nature its bond-accepting ability enabled containing this anion compared hexafluorophosphate-containing ILs. Further pH 6 is optimum for CIP-IL where remained zwitterionic form. Increased temperature strength diminished efficiency, consistent reduced stability complexes under such conditions.

Язык: Английский

Процитировано

0

Porphyrinic metal-organic framework PCN-224 supported Prussian blue enables selective detection of casein and phytic acid DOI
Zhiqiang Zhou, Xiao Zhang, Wenting Chen

и другие.

Talanta, Год журнала: 2025, Номер unknown, С. 128121 - 128121

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Hydrogen-Bond-Assisted Dual-Mode Ratiometric Detection of Uric Acid Using Pyrimidine-Driven Charge Transfer Probes: From Mechanistic Studies to Real-Life Applications DOI
Animesh Pal, Imran Ahmad, Nilanjan Dey

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

The study highlights the design, synthesis, and photophysical evaluation of two pyrimidine-based charge transfer probes (compounds 1 2) for selective detection uric acid (UA) in aqueous environments biological fluids. Both exhibited distinct spectral responses attributable to their structural differences, with compound demonstrating superior sensitivity. Quantitative analysis revealed a strong linear correlation (R2 = 0.998) between UA concentration fluorescence intensity, enabling as low 0.12 μM, which is well within clinically relevant range. Mechanistic investigations confirmed indispensable role pyrimidine unit forming multipoint hydrogen-bonding interactions UA, induced spectroscopic changes disrupted probe aggregates. Environmental factors such pH, polarity, temperature were systematically examined, revealing that performance was optimal at moderate pH (4-8) 60-70% water content, elevated temperatures (50 °C) enhancing response due dissociation supramolecular Screening diluted human urine validated practical applicability probe, high recovery rates minimal matrix interference. also utilized HeLa cells. Also, chemically modified paper strips developed rapid, on-site UA.

Язык: Английский

Процитировано

0

Membrane-Bound Bisindolyl-Based Chromogenic Probes: Analysis of Cyanogenic Glycosides in Agricultural Crops for Possible Remediation DOI

Harshal V. Barkale,

Nilanjan Dey

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

Cyanogenic glycosides are plant-derived, nitrogen-containing secondary metabolites that release toxic cyanide ions upon hydrolysis by glycosidic enzymes. Therefore, consuming food items enriched with such compounds without proper remediation can cause acute intoxication. Thus, in this work, we utilize cyanide-responsive oxidized bisindole-based chromogenic probes to detect cyanogenic glycosides, as amygdalin and linamarin (LOD: 0.12 μM), phospholipid membranes. The bilayer surface, owing its distinct microenvironment, enhances both the sensitivity specificity of toward amygdalin. response (red yellow) is influenced nature lipid membrane (order, polarity, interfacial hydration) well number bis-indolyl units probe molecules. Semiquantitative analysis samples before after cooking revealed soaking water at room temperature significantly reduces glycoside content. ability directly pretreatment a notable aspect investigation.

Язык: Английский

Процитировано

2

Can Conformational Flexibility Influence the Self-Assembly Behavior and Sensing Efficacy of Fluorogenic Amphiphiles? A Case Study with Bisbenzimidazole based Probes DOI

Suraj Pise,

Imran Ahmad, Nilanjan Dey

и другие.

Analytical Methods, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 13, 2024

In this work, we have explored the metal ion sensing properties of two bisbenzimidazole-based fluorescent probes, that differ in their conformational flexibility, an aqueous medium. The compound with a flexible methyl spacer (1) experienced blue shifts its absorption and emission maxima (along turn-off response) upon addition Hg2+ ions. On contrary, relatively rigid structure (2) showed red both when treated under similar conditions. Detailed mechanistic studies indicated 1 formed : 2 complex ions, where pyridine nitrogen ends benzimidazole units are involved coordination. However, for 2, binding stoichiometry changed to ions remained connected only through ends. Not did changes molecular level interactions alter optical response, but they also altered efficacy sensing; degree response was more prominent than 2. Also, it observed could dissociate preformed aggregated structures 1, while case promotes aggregate formation. sensor further utilized analysis real-life water samples detection intracellular conditions (HeLa cells).

Язык: Английский

Процитировано

0