From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes DOI Creative Commons
Lorena Gallego,

K.B. Harvey,

Marta Pevida

и другие.

Biomolecules, Год журнала: 2025, Номер 15(1), С. 132 - 132

Опубликована: Янв. 15, 2025

The aim of the circular economy is to treat waste as a valuable raw material, reintegrating it into industrial and extending lifecycle subsequent products. Efforts reduce production hard-to-recycle are becoming increasingly important manufacturers, not only consumer goods but also specialized items that difficult manufacture, such medical supplies, which have now become priority for European Union. purpose study manufacture novel human-purified type I collagen membrane from bone remnants typically discarded during processing cortico-cancellous bones in tissue banks evaluate its mechanical properties effectiveness regenerating bone-critical mandibular defects rabbits. To prepare membrane, chip samples local bank were processed isolate by demineralization under agitation HCl, cast silicone mold, air-dried at room temperature UV irradiation. average thickness four batches analyzed SEM was 37.3 μm. value Young's modulus tensile strength obtained specimens 2.56 GPa 65.43 Mpa, respectively. membrane's efficacy tested creating critical bicortical bilateral osteoperiosteal defect rabbit mandibles. right-side covered with while left-side left untreated control. Nine weeks post-surgery, clinical, radiological, histological analyses demonstrated new formation treated areas, whereas control sites showed no regeneration. This innovative approach contributes sustainability healthcare optimizing biological exemplifies efficient resource use line economy, offering cost-effective, biocompatible option could benefit national health systems.

Язык: Английский

Biodegradable Piezoelectric Janus Membrane with Enhanced Antibacterial and Osteoinductive Properties for Periodontitis Therapy DOI Open Access
Jingrong Cheng,

Liping Wu,

Hongying Fu

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

An ideal guided bone regeneration (GBR) membrane for periodontitis treatment should incorporate biocompatibility, biodegradability, mechanical strength, antibacterial properties, and osteoconductivity. However, no commercially available GBR meets all these criteria simultaneously. In this study, a novel biodegradable piezoelectric double-layered is developed, with non-piezoelectric Poly-L-lactic acid (PLLA) side facing the gingiva PLLA-ZnO alveolar bone. This asymmetric membrane, distinct fiber orientations charge distribution, combines synergizes degradability, barrier function, activity osteogenic potential to enhance efficacy. The can effectively prevent fibroblast migration, inhibits bacterial infection, promotes both in vitro vivo. testing shows good rate against Porphyromonas gingivalis (P. gingivalis) Staphylococcus aureus (S. aureus) after 10 min of ultrasound stimulation. Expression levels genes Bone morphogenetic Protein 2 (BMP2), Runt-related transcription factor (RUNX2), Osteopontin (OPN) Osteocalcin (OCN) are over twice that control. mouse P. gingivalis-mediated model, our composite demonstrates effective antimicrobial effects promote 2- 4-weeks implantation, facilitated by mechanisms such as physical isolation, zinc ion release, effects, enhanced expression through activation osteogenesis-related signaling pathways, underscoring its strong applications.

Язык: Английский

Процитировано

1
From Waste to Innovation: A Circular Economy Approach for Tissue Engineering by Transforming Human Bone Waste into Novel Collagen Membranes DOI Creative Commons
Lorena Gallego,

K.B. Harvey,

Marta Pevida

и другие.

Biomolecules, Год журнала: 2025, Номер 15(1), С. 132 - 132

Опубликована: Янв. 15, 2025

The aim of the circular economy is to treat waste as a valuable raw material, reintegrating it into industrial and extending lifecycle subsequent products. Efforts reduce production hard-to-recycle are becoming increasingly important manufacturers, not only consumer goods but also specialized items that difficult manufacture, such medical supplies, which have now become priority for European Union. purpose study manufacture novel human-purified type I collagen membrane from bone remnants typically discarded during processing cortico-cancellous bones in tissue banks evaluate its mechanical properties effectiveness regenerating bone-critical mandibular defects rabbits. To prepare membrane, chip samples local bank were processed isolate by demineralization under agitation HCl, cast silicone mold, air-dried at room temperature UV irradiation. average thickness four batches analyzed SEM was 37.3 μm. value Young's modulus tensile strength obtained specimens 2.56 GPa 65.43 Mpa, respectively. membrane's efficacy tested creating critical bicortical bilateral osteoperiosteal defect rabbit mandibles. right-side covered with while left-side left untreated control. Nine weeks post-surgery, clinical, radiological, histological analyses demonstrated new formation treated areas, whereas control sites showed no regeneration. This innovative approach contributes sustainability healthcare optimizing biological exemplifies efficient resource use line economy, offering cost-effective, biocompatible option could benefit national health systems.

Язык: Английский

Процитировано

0