Advancement of Nanomaterials- and Biomaterials-Based Technologies for Wound Healing and Tissue Regenerative Applications

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Patients and healthcare systems face significant social financial challenges due to the increasing number of individuals with chronic external internal wounds that fail heal. The complexity healing process remains a serious health concern, despite effectiveness conventional wound dressings in promoting healing. Recent advancements materials science fabrication techniques have led development innovative enhance To further expedite process, novel approaches such as nanoparticles, 3D-printed dressings, biomolecule-infused emerged, along cell-based methods. Additionally, gene therapy technologies are being harnessed generate stem cell derivatives more functional, selective, responsive than their natural counterparts. This review highlights potential biomaterials, 3D bioprinting, gene- therapies However, it also underscores necessity for research address existing integrate these strategies into standard clinical practice.

Язык: Английский

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Conclusion and future prospects of cellulose-based hydrogels

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 459 - 476

Опубликована: Янв. 1, 2025

Язык: Английский

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Genetic Engineering Revolutionized Scaffold‐Based Bone Regeneration

Advanced Materials Technologies, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract Genetic modification ought to be regarded as a complementary technology that effectively enhances the efficacy of bone rehealing and substitution. Recently, molecular regeneration paths have been uncovered rapid advancement in gene therapy has led heightened interest genetic engineering. Biomaterial scaffold‐mediated offers template for tissue development cell infiltration. Gene‐activated platforms offer an efficient approach precisely delivering genes promote safe effective manner. Moreover, these pathways ability temporarily regulate excessive expression therapeutic genes, resulting localized synthesis regulatory factors at levels are biologically significant. Therefore, application various nucleic acid‐based scaffolds including long noncoding RNAs, short interfering microRNAs, coding mRNAs, plasmids, viral vectors, aptamers, editing tools comprehensively discussed repair regeneration. The bibliography reveals collagen, calcium/phosphate‐based composites, chitosan common scaffolds. Recombinant viruses, miRNAs, siRNAs most prevalent engineering methods. Research findings suggest integration elements biomaterials will revolutionize Tremendous innovations bring such engineered from benches clinics, very soon.

Язык: Английский

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Advances in nucleic acid delivery strategies for diabetic wound therapy

Journal of Clinical & Translational Endocrinology, Год журнала: 2024, Номер 37, С. 100366 - 100366

Опубликована: Авг. 30, 2024

In recent years, the prevalence of diabetic wounds has significantly increased, posing a substantial medical challenge due to their propensity for infection and delayed healing. These not only increase mortality rates but also lead amputations severe mobility issues. To address this, advancements in bioactive molecules such as genes, growth factors, proteins, peptides, stem cells, exosomes into targeted gene therapies have emerged preferred strategy among researchers. Additionally, integration photothermal therapy (PTT), nucleic acid, therapy, along with 3D printing technology layer-by-layer (LBL) self-assembly approach, shows promise wound treatment. Effective delivery small interfering RNA (siRNA) relies on vectors. This review provides an in-depth exploration pathophysiological characteristics observed wounds, encompassing diminished angiogenesis, heightened levels reactive oxygen species, impaired immune function. It further examines acid delivery, advanced drug systems, techniques, negative pressure (NPWT), printing, hyperbaric ongoing clinical trials. Through research insights, this presents innovative strategies aimed at augmenting multifaceted management thus paving way enhanced therapeutic outcomes future.

Язык: Английский

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Recent advances in mesoporous silica nanoparticles formulations and drug delivery for wound healing

International Journal of Pharmaceutics, Год журнала: 2024, Номер 665, С. 124654 - 124654

Опубликована: Сен. 6, 2024

Язык: Английский

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