Structurally Engineered SO2–Releasing Polymeric Nanoassembly for Broad-Spectrum Antibacterial Activity DOI
Anushree Mondal, Tanushree Mondal, Subhamoy Jana

и другие.

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Cationic antimicrobial agents are widely recognized for combating microbial infections through their membrane-disruptive properties. Recently, sulfur dioxide (SO2) gas therapy has emerged as a promising alternative treating diseases, including bacterial infections. However, current systems often target only specific strains. Herein, we present amphiphilic alternating copolymers, DAPx (x = 1, 2, 3), incorporating cationic residues and thiol-responsive SO2-releasing moieties. In aqueous environments, copolymers self-assemble into micellar nanoassemblies (DAPxNp), exposing hydrophilic outward encapsulating hydrophobic moieties within the core to enable controlled sustained release of SO2 in presence glutathione (GSH). vitro studies reveal excellent biocompatibility DAP2 Np with broad-spectrum antibacterial activity against both Gram-positive (Bacillus subtilis, Staphylococcus aureus) Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Mechanistic investigations confirm eradication via membrane disruption reactive oxygen species generation. This study underscores remarkable efficacy polymers resisting

Язык: Английский

Stimuli-responsive and targeted nanomaterials: Revolutionizing the treatment of bacterial infections DOI
Wen Li, Qihang Ding, Meiqi Li

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 495 - 523

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

3

Visible Light‐Triggered Precision SO2 Release from Polymeric Nanomedicine for Cancer Therapy DOI

Anushree Mondal,

Swastika Dey,

Soumya Paul

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract A number of polymeric sulfur dioxide (SO 2 )‐releasing nanomedicines have demonstrated promise in cancer treatment by enabling controlled SO release, triggered endogenous (redox) stimuli. However, the heterogeneous distribution these stimuli across different organs presents a significant challenge to clinical translation. To overcome this limitation, developing donors that respond exogenous triggers offers promising strategy for therapeutic advancement. Herein, an stimuli‐responsive is presented generating from series amphiphilic block copolymers ( BCPx ) under visible light irradiation (427 nm) biological environment, aiming evaluate their potential therapy. The coumarin‐based, water‐soluble polymers form well‐defined nanostructures BCPxNs aqueous media, releasing 70–85% theoretical within 4 h. Moreover, exhibit self‐reporting behavior upon release. In vitro cellular assays with BCP2Ns demonstrate enhanced antiproliferative effect cervical carcinoma HeLa cells nm), IC 50 value 0.3 mg mL −1 . Investigations using confocal microscopy and flow cytometry confirm ‐induced cell death. Overall, underscores light‐responsive spatiotemporal control

Язык: Английский

Процитировано

0

RAFT‐engineered polymeric surfactant: Exploring the self‐assembly of homopolymers from poly(ethylene glycol) methyl ether methacrylate DOI

A. Bagchi,

Pranav Sharma, Puja Poddar

и другие.

Journal of Surfactants and Detergents, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Polymeric surfactants, valued for their ability to stabilize interfaces and tunable self‐assembled structures, find extensive applications in personal care, drug delivery, pharmaceuticals, industrial formulations. To develop an efficient polymeric surfactant, herein we investigate the synthesis characterization of side‐chain poly(ethylene glycol) ( PEG )‐based homopolymers PPEGMAx ), using reversible addition‐fragmentation chain transfer (RAFT) polymerization presence a hydrophobic tail‐functionalized agent (CTA), enabling precise control over molar mass narrow dispersity Đ ). Structural confirmation compositional analysis are performed 1 H nuclear magnetic resonance NMR) spectroscopy. The amphiphilic nature self‐assembly behavior polymers investigated through fluorescence spectroscopy, dynamic light scattering (DLS), atomic force microscopy (AFM). show critical aggregation concentrations range 27–63 μg/mL water, with sizes ranging from 40 80 nm. However, suitable hydrophobic/hydrophilic balance polymer structure is necessary potential as surfactants.

Язык: Английский

Процитировано

0

Structurally Engineered SO2–Releasing Polymeric Nanoassembly for Broad-Spectrum Antibacterial Activity DOI
Anushree Mondal, Tanushree Mondal, Subhamoy Jana

и другие.

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Cationic antimicrobial agents are widely recognized for combating microbial infections through their membrane-disruptive properties. Recently, sulfur dioxide (SO2) gas therapy has emerged as a promising alternative treating diseases, including bacterial infections. However, current systems often target only specific strains. Herein, we present amphiphilic alternating copolymers, DAPx (x = 1, 2, 3), incorporating cationic residues and thiol-responsive SO2-releasing moieties. In aqueous environments, copolymers self-assemble into micellar nanoassemblies (DAPxNp), exposing hydrophilic outward encapsulating hydrophobic moieties within the core to enable controlled sustained release of SO2 in presence glutathione (GSH). vitro studies reveal excellent biocompatibility DAP2 Np with broad-spectrum antibacterial activity against both Gram-positive (Bacillus subtilis, Staphylococcus aureus) Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Mechanistic investigations confirm eradication via membrane disruption reactive oxygen species generation. This study underscores remarkable efficacy polymers resisting

Язык: Английский

Процитировано

0