Stimuli-responsive and targeted nanomaterials: Revolutionizing the treatment of bacterial infections
Journal of Controlled Release,
Год журнала:
2024,
Номер
377, С. 495 - 523
Опубликована: Ноя. 29, 2024
Язык: Английский
Visible Light‐Triggered Precision SO2 Release from Polymeric Nanomedicine for Cancer Therapy
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
Abstract
A
number
of
polymeric
sulfur
dioxide
(SO
2
)‐releasing
nanomedicines
have
demonstrated
promise
in
cancer
treatment
by
enabling
controlled
SO
release,
triggered
endogenous
(redox)
stimuli.
However,
the
heterogeneous
distribution
these
stimuli
across
different
organs
presents
a
significant
challenge
to
clinical
translation.
To
overcome
this
limitation,
developing
donors
that
respond
exogenous
triggers
offers
promising
strategy
for
therapeutic
advancement.
Herein,
an
stimuli‐responsive
is
presented
generating
from
series
amphiphilic
block
copolymers
(
BCPx
)
under
visible
light
irradiation
(427
nm)
biological
environment,
aiming
evaluate
their
potential
therapy.
The
coumarin‐based,
water‐soluble
polymers
form
well‐defined
nanostructures
BCPxNs
aqueous
media,
releasing
70–85%
theoretical
within
4
h.
Moreover,
exhibit
self‐reporting
behavior
upon
release.
In
vitro
cellular
assays
with
BCP2Ns
demonstrate
enhanced
antiproliferative
effect
cervical
carcinoma
HeLa
cells
nm),
IC
50
value
0.3
mg
mL
−1
.
Investigations
using
confocal
microscopy
and
flow
cytometry
confirm
‐induced
cell
death.
Overall,
underscores
light‐responsive
spatiotemporal
control
Язык: Английский
RAFT‐engineered polymeric surfactant: Exploring the self‐assembly of homopolymers from poly(ethylene glycol) methyl ether methacrylate
Journal of Surfactants and Detergents,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
Polymeric
surfactants,
valued
for
their
ability
to
stabilize
interfaces
and
tunable
self‐assembled
structures,
find
extensive
applications
in
personal
care,
drug
delivery,
pharmaceuticals,
industrial
formulations.
To
develop
an
efficient
polymeric
surfactant,
herein
we
investigate
the
synthesis
characterization
of
side‐chain
poly(ethylene
glycol)
(
PEG
)‐based
homopolymers
PPEGMAx
),
using
reversible
addition‐fragmentation
chain
transfer
(RAFT)
polymerization
presence
a
hydrophobic
tail‐functionalized
agent
(CTA),
enabling
precise
control
over
molar
mass
narrow
dispersity
Đ
).
Structural
confirmation
compositional
analysis
are
performed
1
H
nuclear
magnetic
resonance
NMR)
spectroscopy.
The
amphiphilic
nature
self‐assembly
behavior
polymers
investigated
through
fluorescence
spectroscopy,
dynamic
light
scattering
(DLS),
atomic
force
microscopy
(AFM).
show
critical
aggregation
concentrations
range
27–63
μg/mL
water,
with
sizes
ranging
from
40
80
nm.
However,
suitable
hydrophobic/hydrophilic
balance
polymer
structure
is
necessary
potential
as
surfactants.
Язык: Английский
Structurally Engineered SO2–Releasing Polymeric Nanoassembly for Broad-Spectrum Antibacterial Activity
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Cationic
antimicrobial
agents
are
widely
recognized
for
combating
microbial
infections
through
their
membrane-disruptive
properties.
Recently,
sulfur
dioxide
(SO2)
gas
therapy
has
emerged
as
a
promising
alternative
treating
diseases,
including
bacterial
infections.
However,
current
systems
often
target
only
specific
strains.
Herein,
we
present
amphiphilic
alternating
copolymers,
DAPx
(x
=
1,
2,
3),
incorporating
cationic
residues
and
thiol-responsive
SO2-releasing
moieties.
In
aqueous
environments,
copolymers
self-assemble
into
micellar
nanoassemblies
(DAPxNp),
exposing
hydrophilic
outward
encapsulating
hydrophobic
moieties
within
the
core
to
enable
controlled
sustained
release
of
SO2
in
presence
glutathione
(GSH).
vitro
studies
reveal
excellent
biocompatibility
DAP2
Np
with
broad-spectrum
antibacterial
activity
against
both
Gram-positive
(Bacillus
subtilis,
Staphylococcus
aureus)
Gram-negative
(Escherichia
coli,
Pseudomonas
aeruginosa)
bacteria.
Mechanistic
investigations
confirm
eradication
via
membrane
disruption
reactive
oxygen
species
generation.
This
study
underscores
remarkable
efficacy
polymers
resisting
Язык: Английский