Recent Advancements and Future Prospects of Asymmetrically Coordinated Single-Atom Nanozymes with High Enzymatic-like Activity for Biotherapy and Diagnosis: A Review

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Язык: Английский

Engineering Colloidal Nanozymes for Cancer Diagnosis and Therapy: From Surface Chemistry to Catalytic Mechanisms and Precision Medicine

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Colloidal nanozymes, enzyme-mimetic nanocatalysts with tunable catalytic activity, are revolutionizing cancer diagnosis and therapy by integrating precision biomedical functionality. Their ability to regulate redox homeostasis, generate reactive oxygen species (ROS), modulate tumor microenvironments provides a foundation for targeted therapeutic interventions, while their intrinsic properties enhance biosensing imaging early detection. However, the rational design of nanozymes remains challenge, particularly in optimizing efficiency, biocompatibility, specificity tumor-selective reactions. This review explores how surface chemistry, interfacial engineering, mechanisms dictate nanozyme stability, interactions biological systems. We critically analyze fundamental peroxidase-like, oxidase-like, catalase-like, superoxide dismutase (SOD)-like reactions driving applications therapy, as well role biosensors, probes, theranostic platforms diagnosis. Additionally, we examine cutting-edge modification strategies, including atomic dispersion, ligand coordination, defect selectivity reduce off-target effects. By catalysis translational applications, this establishes comprehensive framework advancing nanozyme-based diagnostics therapeutics oncology.

Язык: Английский

Leveraging Nanomaterials for Ultrasensitive Biosensors in Early Cancer Detection: A Review

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Recent advances in nanotechnology revolutionize cancer diagnostics, better than PET-scans and biopsies. Ultrasensitive nanobiosensors spot trace biomarkers effectively, allowing early, precise detection outcomes, altering care globally.

Язык: Английский