Recent Advancements and Future Prospects of Asymmetrically Coordinated Single-Atom Nanozymes with High Enzymatic-like Activity for Biotherapy and Diagnosis: A Review
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Язык: Английский
Engineering Colloidal Nanozymes for Cancer Diagnosis and Therapy: From Surface Chemistry to Catalytic Mechanisms and Precision Medicine
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 29, 2025
Colloidal
nanozymes,
enzyme-mimetic
nanocatalysts
with
tunable
catalytic
activity,
are
revolutionizing
cancer
diagnosis
and
therapy
by
integrating
precision
biomedical
functionality.
Their
ability
to
regulate
redox
homeostasis,
generate
reactive
oxygen
species
(ROS),
modulate
tumor
microenvironments
provides
a
foundation
for
targeted
therapeutic
interventions,
while
their
intrinsic
properties
enhance
biosensing
imaging
early
detection.
However,
the
rational
design
of
nanozymes
remains
challenge,
particularly
in
optimizing
efficiency,
biocompatibility,
specificity
tumor-selective
reactions.
This
review
explores
how
surface
chemistry,
interfacial
engineering,
mechanisms
dictate
nanozyme
stability,
interactions
biological
systems.
We
critically
analyze
fundamental
peroxidase-like,
oxidase-like,
catalase-like,
superoxide
dismutase
(SOD)-like
reactions
driving
applications
therapy,
as
well
role
biosensors,
probes,
theranostic
platforms
diagnosis.
Additionally,
we
examine
cutting-edge
modification
strategies,
including
atomic
dispersion,
ligand
coordination,
defect
selectivity
reduce
off-target
effects.
By
catalysis
translational
applications,
this
establishes
comprehensive
framework
advancing
nanozyme-based
diagnostics
therapeutics
oncology.
Язык: Английский
Leveraging Nanomaterials for Ultrasensitive Biosensors in Early Cancer Detection: A Review
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Recent
advances
in
nanotechnology
revolutionize
cancer
diagnostics,
better
than
PET-scans
and
biopsies.
Ultrasensitive
nanobiosensors
spot
trace
biomarkers
effectively,
allowing
early,
precise
detection
outcomes,
altering
care
globally.
Язык: Английский