Dynamic co‐clustering and self‐sorting in interactive protocell populations DOI
Ananya Mishra,

Helen Price,

Avinash J. Patil

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract The design and implementation of collective actions in model protocell communities is an on‐going challenge synthetic protobiology. Herein, we covalently graft alginate or chitosan onto the outer surface semipermeable enzyme‐containing silica colloidosomes to produce hairy catalytic protocells with pH‐switchable membrane charge. Binary populations enzymatically active exhibit self‐initiated stimulus‐responsive changes spatial organization such that mixed community undergoes alternative modes electrostatically induced self‐sorting reversible co‐clustering. We demonstrate co‐clustering, but not self‐sorting, mitigates signal attenuation a binary sender receiver due increased proximity effects. level correlated time‐dependent pH‐mediated switch populations. Our results pave way towards development programmable networks adaptive life‐like objects could have implications for interactive cytomimetic materials agent‐based robotics.

Язык: Английский

ATP‐Regulated Formation of Transient Peptide Amphiphiles Superstructures DOI Creative Commons
David Cappelletti, Federico Lancia, Andrea Basagni

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Abstract Self‐assembly of biotic systems serves as inspiration for the preparation synthetic supramolecular assemblies to mimic structural, temporal, and functional aspects living systems. Despite peptide amphiphiles (PAs) being widely studied in context biomimetic bioactive nanomaterials, very little is currently known about reversible spatiotemporal control their hierarchical self‐assemblies. Here, it shown that PA‐based nanofibers can transiently form superstructures, through binding with oppositely charged adenosine triphosphate (ATP), leading charge screening stabilization bundled nanofibers. Enzymatic hydrolysis ATP monophosphate phosphates causes disassembly superstructures recovery individual The lifetime be controlled by adjusting concentration either or enzyme. role formation PA has on chemical reactivity catalysis also evaluated. It observed superstructuration responsible downregulation activity, which then recovered gradual bundles. These results demonstrate potential self‐assembly modulate nanostructures.

Язык: Английский

Процитировано

0
Dynamic co‐clustering and self‐sorting in interactive protocell populations DOI
Ananya Mishra,

Helen Price,

Avinash J. Patil

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract The design and implementation of collective actions in model protocell communities is an on‐going challenge synthetic protobiology. Herein, we covalently graft alginate or chitosan onto the outer surface semipermeable enzyme‐containing silica colloidosomes to produce hairy catalytic protocells with pH‐switchable membrane charge. Binary populations enzymatically active exhibit self‐initiated stimulus‐responsive changes spatial organization such that mixed community undergoes alternative modes electrostatically induced self‐sorting reversible co‐clustering. We demonstrate co‐clustering, but not self‐sorting, mitigates signal attenuation a binary sender receiver due increased proximity effects. level correlated time‐dependent pH‐mediated switch populations. Our results pave way towards development programmable networks adaptive life‐like objects could have implications for interactive cytomimetic materials agent‐based robotics.

Язык: Английский

Процитировано

1